Am J Transplant, Volume 20, Suppl 3 Archives - Page 179 of 223 - ATC Abstracts

2020 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation in Diabetic and Prediabetic Patients with Intractable Chronic Pancreatitis
P. J. Bachul¹, D. J. Grybowski¹, R. Anteby², L. Basto¹, L. Perea¹, K. Golab¹, L. Wang¹, M. Tibudan¹, A. Perez-Gutierrez¹, M. Komorniczak³, S. Nagpal⁴, A. Lucander¹, P. Borek¹, M. Dimitrov¹, J. Fung¹, J. B. Matthews¹, P. Witkowski¹
¹Surgery, University of Chicago, Chicago, IL, ²Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ³Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland, ⁴Medicine, University of Chicago, Chicago, IL
*Purpose: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for non-diabetic patients with intractable chronic pancreatitis. The outcome and potential benefits for…
2020 American Transplant Congress
Ex Vivo Isolated Human Vessel Perfusion System for the Design and Assessment of Nanomedicines Targeted to the Endothelium
L. G. Bracaglia¹, T. Lysyy², L. Qin², C. Albert¹, J. S. Pober², G. Tellides², W. M. Saltzman¹, G. T. Tietjen²
¹Yale University, New Haven, CT, ²Yale School of Medicine, New Haven, CT
*Purpose: In solid organ transplantation the host immune system acts to reject the graft. This process is facilitated at the endothelial surface, where inflamed donor…
2020 American Transplant Congress
A Recombinant, Fully Human ATG Polyclonal Antibody Drug Drives Immune Cell Depletion in a Model of Graft-versus-Host Disease
S. M. Keating, A. S. Adler, R. A. Mizrahi, J. Leong, M. A. Asensio, Y. W. Lim, A. R. Niedecken, Y. Chiang, R. Leong, D. S. Johnson
Immunology, GigaGen, South San Francisco, CA
*Purpose: Anti-thymocyte globulin (ATGs) are polyclonal antibody products that target and deplete T cells for immunosuppression in transplantation (prophylaxis of rejection). Since ATGs are derived…
2020 American Transplant Congress
Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway
W. Zijie, Z. Gui, M. Zheng, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…
2020 American Transplant Congress
Comparison of Anti-Thymocyte Globulin and Alemtuzumab as Induction Therapy in Older Kidney Transplant Recipients
M. Chaung, E. Hollinger, M. Brokhof, N. Alvey, L. Lineberger, N. Kenyon
Rush University Medical Center, Chicago, IL
*Purpose: The purpose of this study is to evaluate the safety and efficacy of induction with either anti-thymocyte globulin (ATG) (total dose 5 mg/kg) or…
2020 American Transplant Congress
The Application of Hypothermic Machine Perfusion in Kidney Transplantation from Delay Graft Function High Risk Donor
Y. Li, X. Hu, G. Chen, C. Ding, W. Xue
Kidney Transplantation Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
*Purpose: To investigate the clinical effect of the hypothermic machine perfusion (HMP) method on renal transplantation from high risk donation after citizen death (DCD) and…
2020 American Transplant Congress
Long-Term Outcomes of Kidney Donors with Nephrolithiasis
M. R. D'Costa, M. A. Merzkani, A. Denic, A. F. Mullan, J. J. Larson, W. K. Kremers, W. D. Park, M. P. Alexander, S. J. Taler, N. S. Issa, M. D. Stegall, A. D. Rule
Mayo Clinic, Rochester, MN
*Purpose: Long-term outcomes data of living kidney donors (LKDs) with nephrolithiasis are limited. We assessed the clinical and structural findings and their association with long-term…
2020 American Transplant Congress
Long Term Effect of Tacrolimus Conversion to Sirolimus with Prednisone-Free Regimen in Kidney Allograft Outcomes: A Dynamic Analysis of Graft Survival Using Joint Modeling
S. H. Park¹, B. Ho¹, K. Guo¹, L. Zhao², V. Mas³, J. Leventhal⁴, L. Gallon¹
¹Transplant Nephrology, Northwestern University, Chicago, IL, ²Preventive Medicine, Northwestern University, Chicago, IL, ³University of Tennesse, Memphis, TN, ⁴Transplant Surgery, Northwestern University, Chicago, IL
*Purpose: Findings on long-term impacts of the mammalian target of rapamycin inhibitor inhibitors on kidney allograft are scarce and mixed. A joint modeling approach can…
2020 American Transplant Congress
Validation of PROMIS Computer Adaptive Testing (CAT) Sleep Disturbance Item Bank in Kidney Transplant Recipients
J. Hussain¹, G. Chawla¹, N. Ullah¹, H. Rafiqzad¹, S. J. Bartlett², M. Li³, D. Howell⁴, J. D. Peipert⁵, M. Novak⁶, I. Mucsi¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Centre for Health Outcomes Research, McGill University, Montreal, QC, Canada, ³Department of Supportive Care, Princess Margaret Hospital, Toronto, ON, Canada, ⁴Princess Margaret Cancer Centre, Faculty of Nursing, University of Toronto, Toronto, ON, Canada, ⁵Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁶Centre for Mental Health, University Health Network, Toronto, ON, Canada
*Purpose: To assess the reliability and validity of the PROMIS Sleep Disturbance Item Bank using the Insomnia Severity Index as the primary legacy instrument in…
2020 American Transplant Congress
Clazakizumab (Anti-IL-6) Induces Foxp3+ Tregs in Highly HLA Sensitized Patients Desensitized for HLAi Transplantation (NCT03380962)
S. C. Jordan, S. Ge, N. Ammerman, M. Toyoda, E. Huang, A. Peng, R. Najjar, S. Sethi, S. Williamson, C. Myers, K. Lim, J. Choi, A. Vo
Cedars Sinai Medical Ctr, West Hollywood, CA
*Purpose: Interleukin-6 is an important inflammatory cytokine. In addition, it acts as a growth factor for B-cells, plasma cells and Th17 cells, inhibiting FoxP3+ Treg…