2020 American Transplant Congress
Recipient Myeloid Cell Myeloperoxidase is Required for Nk Cell Activation During Antibody-Mediated Allograft Rejection
Immunology, Cleveland Clinic Lerner Research Institute, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…2020 American Transplant Congress
Recipient LAG3 Deficiency Results in Antibody-Mediated Rejection of Mouse Renal Allografts
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Lymphocyte activation gene-3 (LAG3) is a coinhibitory receptor on the surface of T and B lymphocytes, NK cells and plasmacytoid dendritic cells. Its functions…2020 American Transplant Congress
Examination of the TIGIT/CD226 Axis in Kidney Transplant Recipients
Renal, Brigham and Women's Hospital, Boston, MA
*Purpose: The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) and CD226, two poliovirus receptor-like proteins, are an emerging group of immune checkpoints with…2020 American Transplant Congress
IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…2020 American Transplant Congress
Anti-Thymocyte Globulins Induced Immunomodulatory Effect and Increased Regulatory T Cell in a In Vitro Model of Allogeneic Cell Coculture
*Purpose: Two types of Anti-Thymocyte Globulins (ATG) are commonly used in renal transplantation (Thymoglobuline and Grafalon) and induce severe, dose-dependent and sometimes persistent CD4+ T…2020 American Transplant Congress
Livers from Donation after Cardiac Death (DCD) Offer – Accept or Decline?
Johns Hopkins University, Baltimore, MD
*Purpose: Given the shortage of deceased-donor livers, donation after cardiac death (DCD) provides an opportunity to expand the donor pool. Due to concern over the…2020 American Transplant Congress
p40 Homodimers Indirectly Induce Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts and CTLA-4ig Resistant Graft Rejection via IL-15 Signaling
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: We have reported that longer duration of cold ischemic storage (CIS) prior to transplant resulted in increased proliferation of endogenous donor-reactive CD8 T cells…2020 American Transplant Congress
UNOS Hard to Place Kidneys: Are We Working Too Hard?
Columbia University, New York, NY
*Purpose: Kidneys requiring more than 100 offers before acceptance are defined by UNOS as “hard to place," but many are suitable for transplantation. We sought…2020 American Transplant Congress
Optimal Timing of Renal Transplantation in Simultaneous Heart-Kidney Transplant: A Retrospective Analysis of the UNOS/OPTN Database
Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: In patients receiving a simultaneous heart-kidney transplant (SHKT) the optimal timing of performing the kidney transplant remains controversial. In the immediate approach (iHKT), the…2020 American Transplant Congress
2019 Refined Criteria for Cirrhotic Cardiomyopathy Predict Post Liver Transplant Cardiac Events
*Purpose: Cirrhotic cardiomyopathy (CCM) encompasses systolic ± diastolic dysfunction (DD) in patients with end stage liver disease in the absence of known cardiac disease. The…
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