2020 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
1Northwestern, Chicago, IL, 2UIC, Chicago, IL, 3Duke, Durham, NC, 4U Louisville, Louisville, KY
*Purpose: 37 pts have been transplanted since 2009 in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The…2020 American Transplant Congress
Identifying Optimal Recipients for DCD Livers: Minimizing Risks of Liver Transplantation with DCD Livers by Matching to Preferred Recipients
Johns Hopkins University, Baltimore, MD
*Purpose: Donation after cardiac death (DCD) livers represent a possible expansion to the donor pool, but are frequently discarded as they are associated with a…2020 American Transplant Congress
Molecular Diagnosis and Risk Prediction in BK Virus Nephropathy: Discovery and Multicenter Validation of Novel Intragraft Gene Expression Signatures
*Purpose: Novel tools are needed to improve diagnosis and risk prediction in BK virus nephropathy (BKVN). This study aimed to assess the utility of intragraft…2020 American Transplant Congress
Can Cxcr3+Cd62l–Cd4+ T Cells Serve as Early Warning Sentinels for Subclinical Rejections after Vascularized Composite Allotransplantation (vca)?
*Purpose: New microsurgical techniques and powerful immunosuppressive drugs have made it possible for severely injured patients to receive VCA to replace limbs, hands, or faces,…2020 American Transplant Congress
Impact of Variation in Histological Assessments and Their Impact on Clinical Trial Enrollment and Endpoints – Preliminary Report of The Gen04 Study
*Purpose: Renal allograft histology is often used as inclusion criteria for clinical trials. This includes Gen04, which is an NIH sponsored multi-center clinical trial involving…2020 American Transplant Congress
Recipient Expression of C-Type Lectin Receptor Mincle Promotes Rapid T Cell Homeostatic Recovery Following Antibody Mediated Lymphoablation
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Antibody-mediated lymphocyte depletion is widely used in transplantation. We recently established that T cell recovery in mouse heart allograft recipients treated with anti-thymocyte globulin…2020 American Transplant Congress
To Fix or Not to Fix: Kidney Outcomes Requiring Renal Artery Reconstruction Due to Surgical Damage
Miami Transplant Institute, Miami, FL
*Purpose: Deceased donor kidneys damaged surgically during procurement are often discarded. Because of the critical shortage of available kidneys for waitlisted ESRD patients, our center…2020 American Transplant Congress
Between-Center Variation in the Survival Benefit of Liver Transplant in the United States
*Purpose: Survival benefit of liver transplantation is strongly correlated with Model for End Stage Liver Disease (MELD) score at transplant. Variability in organ supply across…2020 American Transplant Congress
Ferroptotic Cell Death During Cold Storage is Essential in Liver Transplant Injury
*Purpose: It has been reported that activation of apoptosis signaling-regulating kinase 1 (ASK1)/p-p38 axis during tissue cold storage results in ferroptotic cell death. Ferroptosis is…2020 American Transplant Congress
Effect of Glecaprevir/Pibrentasvir on Weight-Adjusted Tacrolimus Trough/Dose Ratios in Heart and Kidney Recipients
*Purpose: An innovative strategy to meet the demands of patients requiring heart or kidney transplantation is the acceptance of hepatitis C viremic organs. Direct acting…
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