ATC Abstracts

American Transplant Congress abstracts

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  • 2020 American Transplant Congress

    Noninvasive Genotyping of Donor’s HLA in Kidney Transplant Patients by Target Capture Sequencing

    T. Jiang, L. Shu, F. Liu, H. Liu, J. Ge

    AlloDx, Shanghai; Suzhou, China

    *Purpose: Antibody-mediated rejection (ABMR) is the major cause of kidney transplant failure, which requires donor-specific antibodies (DSA) for a definitive diagnosis based on Banff 2013.…
  • 2020 American Transplant Congress

    Induction of Delayed Immune Tolerance after Reconstructive Transplantation by Combining Donor Bone Marrow Transplantation and High-Dose Cyclophosphamide Treatment

    Y. Guo1, F. Messner1, B. Oh1, G. Furtmüller1, W. Lee1, D. Cooney1, L. Luznik2, G. Brandacher1

    1Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 2Hematology, Johns Hopkins University School of Medicine, Baltimore, MD

    *Purpose: Immunosuppression avoidance by induction of immune tolerance represents a primary goal in the field of transplantation. Yet, success of this concept relies on extensive…
  • 2020 American Transplant Congress

    Evaluation of Pretransplant Serologies and Vaccination Rates in Kidney Transplant Candidates

    S. Schneider, C. Truax, A. Carlson, B. Clark, B. Sirandas, L. Smith

    Department of Pharmacy Services, University of Utah Health, Salt Lake City, UT

    *Purpose: Assessing serologic status presents opportunities to provide live vaccinations to solid organ transplant (SOT) candidates. This is especially important given the increased risk of…
  • 2020 American Transplant Congress

    Noninvasive Detection of Subclinical Rejection in Urine RNA

    K. S. Keslar1, D. Margeta1, J. J. Friedewald2, M. Abecassis2, R. B. Mannon3, P. S. Heeger4, R. L. Fairchild1

    1Cleveland Clinic, Cleveland, OH, 2Northwestern University, Chicago, IL, 3University of Alabama at Birmingham, Birmingham, AL, 4Icahn School of Medicine, New York, NY

    *Purpose: Subclinical rejection may lead to long-term graft injury and can currently only be detected by repeated biopsies. A noninvasive method is needed to monitor…
  • 2020 American Transplant Congress

    Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?

    N. Parajuli, A. Khakurel

    University of Arkansas for Medical Sciences, Little Rock, AR

    *Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
  • 2020 American Transplant Congress

    ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Mercuric Chloride-Induced Renal Dysfunction and Mortality in Rats

    P. Narayan, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: ANG-3777 is a small-molecule mimetic of hepatocyte growth factor (HGF). In vitro models have shown ANG-3777 to have protective effects in renal cell lines,…
  • 2020 American Transplant Congress

    Ex Vivo Generated Regulatory B Cells Can Suppress Donor-Specific CD4 T Cells Proliferation In Vivo

    G. Huai1, K. M. Lee1, Q. Fu1, K. Deng1, N. J. Feeney1, C. Leguern1, N. Tanimine1, C. G. Rickert1, S. Deng2, J. F. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 2Organ Transplantation Center, Sichuan Provincial People's Hospital and School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

    *Purpose: B cells expanded in vitro via TLR9 agonist CpG and activated by LPS, PMA and ionomycin have been previously denoted “TLR-Bregs” by our team.…
  • 2020 American Transplant Congress

    Characterization of CpG-stimulated, Tlr Regulatory, and Expanded Regulatory B Cells by RNA-Seq

    Q. Fu, G. C. Rickert, K. Lee, G. Huai, K. Deng, N. Feeney, N. Tanimine, A. Cuenca, S. Deng, J. F. Markmann

    Center for Transplant Science, MGH, Boston, MA

    *Purpose: Our group previously reported three different types of in vitro generated B cell populations. Expanded regulatory B cells (eBregs), TLR regulatory B cells (TLR-Bregs),…
  • 2020 American Transplant Congress

    Activation of Tacrolimus Induced Cytotoxicity Through Apoptotic Pathways

    S. Chung, S. Choi

    Department of Surgery, Chonnam National University, Gwangju, Korea, Republic of

    *Purpose: To elucidate the mechanism of cytotoxicity in FK506-treated Jurkat T cells, signal transduction pathway of TNF-related events was studied.*Methods: Viability of Jurkat T cells…
  • 2020 American Transplant Congress

    Decreased Anti-Tumor Activity of Liver-Resident NK Cells via IL-33 Associated with Portal Hypertension after Living Donor Liver Transplantation

    Y. Imaoka, M. Ohira, K. Sato, H. Ohdan

    Hiroshima Uni., Hiroshima, Japan

    *Purpose: It has been reported that increasing portal vein pressure after living donor liver transplantation (LDLT) was associated with a poor prognosis, risk factors for…
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