Am J Transplant, Volume 20, Suppl 3 Archives - Page 146 of 223 - ATC Abstracts

2020 American Transplant Congress
Expression of Multiple Human Complement Regulatory Proteins Results in Prolonged Heterotopic Xenoheart Survival in an NHP Model
K. Ahrens¹, J. M. O¹, W. Sommer², D. Becerra¹, P. M. Patel¹, A. Dehnadi¹, Y. Kan³, J. Layer³, J. Morrissette¹, T. Costa¹, I. M. Hanekamp¹, J. S. Allan⁴, M. Youd³, R. N. Pierson⁵, W. Qin³, L. Burdorf⁵, A. M. Azimzadeh¹, W. Westlin³, L. Yang³, J. C. Madsen⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³eGenesis Inc., Cambridge, MA, ⁴Center for Transplantation Sciences, Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, ⁵Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Advances in genome engineering technology allow for multiplex genetic modifications in pigs designed to address immunologic and coagulation incompatibilities in order to facilitate xenotransplantation.…
2020 American Transplant Congress
Rare HLA DRB1*10-DQB1*06 Linkage Disequilibrium: A Case Study That Emphasizes the Need of Having an HLA Toolbox
S. Dionne, L. Santiago, S. Shetty
VRL-Eurofins, Centennial, CO
*Purpose: This case study highlights the need to use different tools to derive and validate HLA typing results especially in instances of rare typing.*Methods: Low/intermediate…
2020 American Transplant Congress
The Development of an Innovative Training Pathway for Robotic Assisted Renal Transplant Program
H. Pournik¹, J. Castillo², V. Brown², J. Collins², C. Haisch², D. Leeser²
¹ECU, Greenville, NC, ²Surgery, East Carolina University, Greenville, NC
*Purpose: To develop and implement a surgeon and team training program for robotic renal transplants utilizing innovative technology and techniques.*Methods: A graduated robotic educational program…
2020 American Transplant Congress
Age- and Sex-Mediated Differences in T Lymphocyte Populations of Kidney Transplant Recipients
R. Dziarmaga¹, D. Ke¹, V. Phan², H. Cardinal³, R. Sapir-Pichhadze¹, C. A. Piccirillo¹, B. Mazer¹, B. Foster¹
¹Research Institute - McGill University Health Centre, Montreal, QC, Canada, ²Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada, ³Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, QC, Canada
*Purpose: Kidney allograft failure rates peak between 17 to 24 years of age and are higher in young female than male kidney transplant recipients (KTR).…
2020 American Transplant Congress
Unique Genomic & Proteomic Profile of Liver Mesenchymal Stromal Cells is Associated with Their Superior Immunomodulatory Properties
F. Yigitbilek, W. D. Park, N. Abrol, M. D. Stegall, T. Taner
Transplant Center, Mayo Clinic, Rochester, MN
*Purpose: Investigating mechanisms of liver allografts’ relative tolerance, we recently reported that liver mesenchymal stromal cells (L-MSC) are superior in their capacity to inhibit alloimmune…
2020 American Transplant Congress
Characterization of Laminin Alpha 4 Conditional Knockout Mice: Model for Immune Stimulation
M. W. Shirkey, L. Li, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Paluskievicz, J. Bromberg
U. Maryland, Baltimore, MD
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We created a Lama4 conditional knockout (KO)…
2020 American Transplant Congress
Donor and Recipient Sex Affect Transplant Outcomes in an Age-Specific Fashion
R. Maenosono¹, Y. Nian¹, J. Iske¹, Y. Liu¹, H. Azuma², E. Milford³, S. G. Tullius¹
¹Division of Transplant Surgery, Brigham and Women's Hospital, Boston, MA, ²Urology, Osaka Medical College, Osaka, Japan, ³Renal Division, Brigham and Women's Hospital, Boston, MA
*Purpose: Donor and recipient sex impact transplant outcomes. The biology of sex-specific alloimmune responses has not been studied in detail.*Methods: Using clinical data from more…
2020 American Transplant Congress
Exosomes Derived from MSC Ameliorate Renal Ischemic-Reperfusion Injury Through Inhibiting Inflammation and Cell Apoptosis
Y. Jia, M. Xu, T. Zhu
Shanghai Key Laboratory of Organ Transplantation, Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: Investigate the underlying mechanism of mesenchymal stem cells (MSCs) on protection of renal ischemia reperfusion injury (IRI) .*Methods: Exosomes originated from MSCs (MSC-ex) were…
2020 American Transplant Congress
The Financial Concerns of Non-Directed (Altruistic) Living Kidney Donors – How Can We Improve the Donation Process?
A. Maghen¹, G. Mendoza¹, G. B. Vargas¹, S. E. Connor¹, S. Nassiri¹, L. Kwan¹, E. L. Wood¹, J. Lalezari¹, S. Friedman¹, A. D. Waterman², S. George³, S. L. Maliski⁴, J. L. Veale¹
¹Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Community Health Sciences, UCLA Fielding School of Public Health, Los Angeles, CA, ⁴Office of the Dean, University of Kansas Medical Center School of Nursing, Kansas City, KS
*Purpose: The recent increase in non-directed (altruistic) kidney donors (NDDs) in the United States (U.S.) suggests their potential to help reduce the overburdened kidney transplant…
2020 American Transplant Congress
Thymoglobulin Induction in Kidney Transplant Recipients: A Single Center Experience Comparing 3 Mg/kg vs 5 Mg/kg Cumulative Dosing
K. Progar¹, S. January¹, N. Nesselhauf¹, J. Hagopian¹, A. Malone²
¹Transplant, Barnes-Jewish Hospital, St. Louis, MO, ²Transplant Nephrology, Washington University, St. Louis, MO
*Purpose: Beginning in 2016, our center implemented a protocol change to thymoglobulin (r-ATG) induction dosing in kidney transplant recipients at low rejection risk from 5…