2020 American Transplant Congress
Tracking Tregs in a Non-Human Primate Model with Expanded Autologous Treg Infusions In Vivo
*Purpose: Regulatory Tcell (Treg) therapy is a promising tool for tolerance induction in solid organ transplantation. Despite encouraging results in humans and monkeys, questions about…2020 American Transplant Congress
Building Kidneys from Stem Cells for Transplantation
*Purpose: Our vision is to build a human kidney by combining human stem cells with porcine kidney extracellular matrix.*Methods: Kidneys were decellularized followed by repopulation…2020 American Transplant Congress
Recipient Myeloid Cell Myeloperoxidase is Required for Nk Cell Activation During Antibody-Mediated Allograft Rejection
Immunology, Cleveland Clinic Lerner Research Institute, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…2020 American Transplant Congress
Recipient LAG3 Deficiency Results in Antibody-Mediated Rejection of Mouse Renal Allografts
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Lymphocyte activation gene-3 (LAG3) is a coinhibitory receptor on the surface of T and B lymphocytes, NK cells and plasmacytoid dendritic cells. Its functions…2020 American Transplant Congress
Examination of the TIGIT/CD226 Axis in Kidney Transplant Recipients
Renal, Brigham and Women's Hospital, Boston, MA
*Purpose: The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) and CD226, two poliovirus receptor-like proteins, are an emerging group of immune checkpoints with…2020 American Transplant Congress
IL-10 Signaling in T Cells is Essential for Induction of Transplant Tolerance
Plastic Surgery, Johns Hopkins University, Baltimore, MD
*Purpose: Induction of long term transplant survival by “costimulation blockade” (CoB) is achieved through deletion of abortively activated alloreactive T cells and generation of graft…2020 American Transplant Congress
Anti-Thymocyte Globulins Induced Immunomodulatory Effect and Increased Regulatory T Cell in a In Vitro Model of Allogeneic Cell Coculture
*Purpose: Two types of Anti-Thymocyte Globulins (ATG) are commonly used in renal transplantation (Thymoglobuline and Grafalon) and induce severe, dose-dependent and sometimes persistent CD4+ T…2020 American Transplant Congress
Livers from Donation after Cardiac Death (DCD) Offer – Accept or Decline?
Johns Hopkins University, Baltimore, MD
*Purpose: Given the shortage of deceased-donor livers, donation after cardiac death (DCD) provides an opportunity to expand the donor pool. Due to concern over the…2020 American Transplant Congress
p40 Homodimers Indirectly Induce Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts and CTLA-4ig Resistant Graft Rejection via IL-15 Signaling
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: We have reported that longer duration of cold ischemic storage (CIS) prior to transplant resulted in increased proliferation of endogenous donor-reactive CD8 T cells…2020 American Transplant Congress
A Single-Center Analysis of Using Allele-Level 11 HLA Loci Information on cPRA and Organ-Allocation Points in Kidney Transplant Candidates
*Purpose: Calculated panel reactive antibodies (cPRA) is used by the United Network for Organ Sharing (UNOS) to quantify degree of HLA sensitization and assign priority…
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