Am J Transplant, Volume 20, Suppl 3 Archives - Page 139 of 223 - ATC Abstracts

2020 American Transplant Congress
Normothermic Ex Vivo Perfusion of Marginal Liver Grafts Rapidly Stimulates Release of Graft-Derived Exosomes and Markedly Decreases the Inflammatory Pathways Induced at Early Times after Transplant Reperfusion
K. E. Brown¹, K. S. Keslar¹, D. Margeta¹, Q. Liu², A. Simioni², L. Del Angel Diaz², W. M. Baldwin¹, R. L. Fairchild¹, C. Quintini²
¹Lerner Research Institute, Cleveland Clinic, Cleveland, OH, ²Transplant Center, Cleveland Clinic, Cleveland, OH
*Purpose: Normothermic ex vivo machine perfusion of liver grafts (EVLP) is emerging as a superior preservation technology to cold storage. Normothermic EVLP transforms a metabolically…
2020 American Transplant Congress
Pre-Transplant Pharmacogenetics Identifies CYP3A4 and CYP3A5 Heterogeneity among Caucasian Kidney Transplant Recipients
N. Oliver¹, L. Lindberg¹, S. LeCorchick¹, D. Morris¹, S. Anand¹, T. Srinivas²
¹Intermountain Medical Center, Murray, UT, ²University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Tacrolimus has always been dosed based on therapeutic drug monitoring, however pharmacogenomics is becoming increasingly more utilized in the era of precision based medicine…
2020 American Transplant Congress
Informed Consent and Decision Making for Upper Extremity VCA
B. Kuramitsu¹, C. Berumen¹, A. Ferzola², H. Sung², C. Kim³, D. Scarton³, T. McHugh³, A. Schultheis³, T. Riggleman³, J. Taylor³, M. Henderson², G. Brandacher², S. Tintle³, E. Gordon¹
¹Northwestern U Feinberg Sch of Medicine, Chicago, IL, ²Johns Hopkins School of Medicine, Baltimore, MD, ³Walter Reed National Military Medical Center, Bethesda, MD
*Purpose: The field of upper rxtremity (UE) Vascularized Composite Allotransplantation (VCA) continues to advance with more patients undergoing the informed consent process each year. However,…
2020 American Transplant Congress
Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors
M. Al-Kofahi¹, W. Oetting¹, A. Israni², D. Schladt³, W. Guan⁴, B. Wu⁴, C. Dorr⁵, R. Remmel⁶, R. Mannon⁷, N. Pankratz⁸, A. Matas⁹, P. Jacobson¹
¹Experimental and Clinical Pharmacology, Univ of MN, College of Pharmacy, Minneapolis, MN, ²Nephrology, Univ of MN and Hennepin HealthCare, Minneapolis, MN, ³Hennepin HealthCare Research Institute, Hennepin HealthCare, Minneapolis, MN, ⁴Biostatistics, Univ of MN, Minneapolis, MN, ⁵Nephrology, Hennepin HealthCare, Minneapolis, MN, ⁶Medicinal Chemistry, Univ of MN, College of Pharmacy, Minneapolis, MN, ⁷Nephrology, Univ of Alabama, Minneapolis, MN, ⁸Lab Medicine Pathology, Univ of MN, Minneapolis, MN, ⁹Surgery, Univ of MN, Minneapolis, MN
*Purpose: Variants in CYP3A4/5 genes, clinical factors and drug-drug interactions are associated with tacrolimus (TAC) clearance and dose. This results in high intra- and inter-…
2020 American Transplant Congress
Kidney Transplantation in Inherited Kidney Diseases
Y. Caliskan¹, H. Yazici², R. Ouseph¹, Y. Ozluk³, H. Randall⁴, E. Demir², F. Savran Oguz⁵, A. Turkmen², M. S. Sever², K. Lentine¹
¹Division of Nephrology, Saint Louis University, Saint Louis, MO, ²Division of Nephrology, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Department of Pathology, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁴Center for Abdominal Transplantation, Saint Louis University, Saint Louis, MO, ⁵Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul, Turkey
*Purpose: We aimed to evaluate the kidney transplant (KTx) recipients with inherited kidney diseases and investigate the causal genetic variants in recipients with undetermined etiology.*Methods:…
2020 American Transplant Congress
Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers
I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…
2020 American Transplant Congress
The Therapeutic Potential of Human Liver-Derived Stem Cells Transplantation in Carbon Tetrachloride-Induced Rat Liver Cirrhotic Model
S. Lee¹, J. Lee², H. Park², Y. Kim², S. Lee¹
¹Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Mesenchymal stem cells (MSCs) have been reported to…
2020 American Transplant Congress
Characterization of Non HLA Antibodies in Kidney Transplant Recipients
S. Rodriguez Ramirez¹, S. Clotet-Freixas¹, C. Mcevoy¹, M. Kotlyar², I. Jurisica², A. Chruscinski¹, A. Konvalinka³
¹Kidney Transplant, Toronto General Hospital Research Institute, Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Kidney Transplant, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ³Kidney Transplant, Department of Medicine, Division of Nephrology, University Health Network, Toronto, ON, Canada
*Purpose: Antibody mediated rejection (AMR) causes more than 60 percent of late graft failures in kidney transplants (KT). Although antiHLA donor specific antibodies are the…
2020 American Transplant Congress
Targeting the CD40/CD40L Axis in Sensitized Nonhuman Primate Allotransplantation
Z. W. Fitch, R. Schmitz, M. Manook, A. Y. Choi, J. Yoon, J. Kwun, S. J. Knechtle
Duke University, Durham, NC
*Purpose: Blockade of the CD28/B7 costimulation pathway has shown great promise as part of desensitization and maintenance immunosuppression regimens in our sensitized nonhuman primate model.…
2020 American Transplant Congress
A Single-Cell Transcriptome Atlas of 15 Adult Human Organs
Z. Guo¹, S. He², L. Wang¹, Y. Liu², J. Xu¹, J. Bei², X. He¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²The Cancer Centre of Sun Yat-Sen University, Guangzhou, China
*Purpose: The transcriptome diversity of cell types within and across tissues is of great importance for biological function of human beings. Here we conducted a…