Am J Transplant, Volume 20, Suppl 3 Archives - Page 134 of 223 - ATC Abstracts

2020 American Transplant Congress
Cell-Free DNA (cfDNA) is Released by Necroptosis and Promotes Kidney Ischemia Reperfusion Injury
A. C. Dionne
Microbiology and Immunology, Western University, London, ON, Canada
*Purpose: Transplantation is invariably associated with ischemia reperfusion injury (IRI) which causes organ dysfunction. IRI is also directly linked to several forms of programmed cell…
2020 American Transplant Congress
Vesicle-Associated Tweak is Increased During Acute Cellular Rejection and Contributes to Endothelial Inflammation
O. Gidlof, J. Sadrian, M. Grossi, S. Alcevska, J. Lundgren, G. Rådegran, G. Smith
Cardiology, Lund University, Lund, Sweden
*Purpose: Extracellular vesicles (EVs) are released from immune cells upon activation and play direct roles in allograft tolerance and rejection, in part through delivery of…
2020 American Transplant Congress
Oral Administration of Nano-Sized Silicon Particles Regulates Gene Expression Related to Oxidative Stress and Attenuates Rat Renal Ischemia Reperfusion Injury
M. Kawamura¹, R. Imamura¹, Y. Kobayashi², A. Taniguchi¹, S. Nakazawa¹, T. Kato¹, T. Abe¹, H. Kobayashi², N. Nonomura¹
¹Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan, ²The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan
*Purpose: Organ ischemia reperfusion injury (IRI) is unavoidable in kidney transplantation and induces reactive oxygen species and causes organ damage. Although the effectiveness of hydrogen…
2020 American Transplant Congress
Human, Monkey Transplant Tolerance and IL35 “Exokine
W. J. Burlingham¹, E. Jankowska-Gan², D. Lema², J. H. Fechner², J. A. Sullivan², D. B. Kaufman²
¹University of Wisconsin, Madison, WI, ²Surgery, University of Wisconsin, Madison, WI
*Purpose: Studies in B6 (H2b) mice tolerized to CBA (H2k) have shown that induced allospecific Tregs make 2 very different forms of immunoregulatory cytokines: 1)…
2020 American Transplant Congress
Thymoglobulin Dose and Incidence of Biopsy Proven Acute Rejections in the Early Post Transplant Period
K. Shimko, K. Schonder, D. Jorgensen, K. Kalra, A. Cherukuri, R. Mehta, I. Melgarejo, P. Sood, S. Hariharan, R. Mehta
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Optimal dosing of thymoglobulin (ATG) for induction has not been well defined. Our protocol aims for 5-6mg/kg cumulative dose divided over 4 doses. However,…
2020 American Transplant Congress
When CPRA Zero is Not the Hero: Does KAS Disadvantage Unsensitized Relisted Patients?
M. Casey, Z. Su, M. Mohamed Ahmed, D. Taber, E. Weeda, T. Morinelli, P. Mauldin, K. Soliman, M. A. Posadas-Salas, V. Rao, D. DuBay
Medical University of South Carolina, Charleston, SC
*Purpose: Since the 2014 Kidney Allocation System (KAS) changes, patients with a very high calculated panel reactive antibody (CPRA) have received greater priority in deceased…
2020 American Transplant Congress
Impact of Focal Cortical Necrosis (CN) in Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation
S. S. Nair, J. Ninan, R. Heilman, K. Reddy, M. Smith
Mayo Clinic, Phoenix, AZ
*Purpose: The data on outcomes of focal CN in PBx after deceased donor transplantation is sparse. We studied the prognostic value of focal CN on…
2020 American Transplant Congress
Risk Factors for Adverse Clinical Outcomes amongst Renal Transplant Candidates Undergoing Screening Angiography for Coronary Artery Disease
M. Shah¹, A. Yung¹, J. Ebinger¹, J. Mirocha², E. Huang³, D. Geft¹, A. Peng³, B. Azarbal¹
¹Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³Department of Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Patient’s with ESRD undergoing evaluation for kidney transplantation routinely undergo screening for coronary artery disease (CAD). Screening recommendations in this population differ between ACC/AHA…
2020 American Transplant Congress
Post-Transplant Collagen I and Collagen III Antibodies and Antibody-Mediated Rejection in Kidney Transplantation Recipients
S. Park¹, S. Yang², J. Kim², Y. Kim², Y. Kim², J. Ha², K. Moon², E. Song², H. Lee²
¹Armed Forces Capital Hospital, Gyeonggi-do, Korea, Republic of, ²Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: An emerging role of non-human leukocyte antigen (HLA) antibodies on the risk of antibody-mediated rejection (AMR) has been suggested, although most of their non-HLA…
2020 American Transplant Congress
Multi- National Survey among Nephrologists & Transplant Surgeons about the Suitability and Acceptance of the Marginal Live Kidney Donors with Active Heavy Smoking or Intermittent Drug Abuse
Z. Arabi¹, A. Hamad², S. Kaysi³, M. Bukhari⁴
¹KAMC, Riyadh, Saudi Arabia, ²The Regional Medical Center, Orangeburg, SC, ³CHU Clermont-Ferrand, Saint Pryv/ Saint Mesmin, France, ⁴Taif University, Taif, Saudi Arabia
*Purpose: Potential kidney donors who actively smoke heavily or had intermittent illegal drug use (IIDU) are mostly excluded from donating a kidney. Tobacco use in…