2020 American Transplant Congress
A Long-Term Follow-Up Study of High-Dose Intravenous Cyclosporine Combined Plasma Exchange in the Treatment of FSGS Recurrence after Renal Transplantation – A Single Center Clinical Experience
*Purpose: There was still lack of effective treatment for focal segmental glomerulosclerosis(FSGS)recurrence after renal transplantation. The purpose of this study was to explore the risk…2020 American Transplant Congress
The Use of Allosure Donor Derived Cell-Free DNA in a Community Based Kidney Transplant Program
Kidney Transplantation, Christiana Care Hospital, Newark, DE
*Purpose: Donor derived cell-free DNA (dd-cfDNA) has emerged as a marker of kidney allograft injury. Beginning in 2019, the dd-cfDNA monitoring has been introduced as…2020 American Transplant Congress
New IGL-2 Perfusate in Liver HOPE Strategies
*Purpose: HOPE has shown to optimize graft liver preservation. However, the most used perfusion solutions as such as Belzer-MPS and its generics were initially for…2020 American Transplant Congress
Gal9/Tim-3 Pathway was Required for Endometrial Stem Cells to Induce Peripheral Tolerance of Cardiac Allograft
*Purpose: The existing immunosuppressants seem to have little effect on Cardiac Allograft Vasculopathy but with obvious side effects. ERCs (Endometrial stem Cells), which are mesenchymal-like…2020 American Transplant Congress
Production of Detergent-Free ECM-Derived Bioinks for Bioprinting of Bionic Pancreas Ready for Clinical Use
*Purpose: Bioprinting is the process of creating 3D tissue analogues. For this purpose, it is necessary to produce a special bioink that will be able…2020 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…2020 American Transplant Congress
Laminin Alpha5 Regulates T Cell Entry and Distribution in Lymph Nodes in Immunity
1UMB, Baltimore, MD, 2Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) and α4 (Lama4) are lymph node (LN) stromal fibers whose expression ratio influences CD4+ T cell migration and stimulation. We hypothesized…2020 American Transplant Congress
DEPTOR Expression within CD4+Foxp3+ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation
1Boston Children's Hospital, Boston, MA, 2Lavel University, Quebec, QC, Canada
*Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…2020 American Transplant Congress
CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus
*Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…2020 American Transplant Congress
Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients
*Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…
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