Am J Transplant, Volume 20, Suppl 3 Archives - Page 12 of 223 - ATC Abstracts

2020 American Transplant Congress
Prolonged Cold Ischemia Increases Reactive Oxygen Species Activates Autophagy by Enhancing Glycolysis in the Graft Through the mTOR Signaling Pathway in Orthotopic Lung Transplantation of Rats
H. Lin¹, S. Dai², W. Liu³, X. Lin², B. Yu², S. Chen³, S. Liu², J. Tang²
¹Thoracic Surgery, Wuhan University, Renmin Hospital, Wuhan, China, ²Thoracic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, China, ³Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China
*Purpose: The aim of the present study is to investigate the mechanisms by which prolonged CI influences the autophagy in the graft lung, in which…
2020 American Transplant Congress
Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein
C. Suo, Z. Gui, Z. Wang, J. Zhou, M. Zheng, H. Chen, S. Fei, L. Sun, X. Zhang, M. Gu, R. Tan
Jiangsu Province Hospital, Nanjing, China
*Purpose: Allograft interstitial fibrosis and fibrogenesis significantly exacerbate the progression of chronic allograft disease (CAD) and are essential therapeutic targets. Epithelial‐mesenchymal transition (EMT) is recognized…
2020 American Transplant Congress
Evaluating Postoperative Opioid Requirements of Kidney Transplant Recipients
M. A. Muir¹, K. R. Szempruch², R. E. Dupuis¹, A. H. Toledo³, P. Serrano Rodriguez³
¹Pharmacotherapy and Experimental Therapeutics, UNC Eshleman School of Pharmacy, Chapel Hill, NC, ²Pharmacy, UNC Medical Center, Chapel Hill, NC, ³Surgery - Transplant, UNC Medical Center, Chapel Hill, NC
*Purpose: Multimodal analgesia with non-opioid analgesics in the setting of enhanced recovery after surgery (ERAS) pathway has proven beneficial in managing pain and decreasing adverse…
2020 American Transplant Congress
Decision-Making, Motivations and the Donation Experience among HLA-Identical Living Kidney Donors at UCLA – A Qualitative Study
E. L. Wood¹, S. George², N. Kogut¹, E. Lum³, J. Veale¹
¹Urology, UCLA, Los Angeles, CA, ²Fielding School of Public Health, UCLA, Los Angeles, CA, ³Medicine, Nephrology, UCLA, Los Angeles, CA
*Purpose: Studies on motivations and decision-making processes of living donors have previously identified recipient relationship, fear of loss and altruism as important modifying factors of…
2020 American Transplant Congress
New Onset Diabetes after Transplant (NODAT) in Hispanic Kidney Transplant Recipients: A Multi-Center Retrospective Study
R. Alsheikh¹, L. Kodali², O. Alfayez³, M. Alshibani¹, A. Basilim¹, M. Fazel⁴
¹King Abdulaziz University, Jeddah, Saudi Arabia, ²Mayo Clinic, Scottsdale, AZ, ³Qassim University, Buraydah, Saudi Arabia, ⁴University of Arizona, Tucson, AZ
*Purpose: Hispanic ethnicity is one of the reported risk factors for NODAT in kidney transplant recipients (KTR). The purpose of our study is to determine…
2020 American Transplant Congress
Pre-Donation CKD-EPI GFR is Superior to Iothalamate Split Scan Results in Predicting 6-Month Post-Nephrectomy Donor Kidney Function
J. R. Montgomery, A. Zondlak, C. S. Brown, A. Pinsky, K. Walsh, J. Kozlowski, E. A. Herriman, Y. Lu, R. S. Sung, K. J. Woodside
General Surgery, University of Michigan, Ann Arbor, MI
*Purpose: Predicting post-donation GFR remains a challenge during living kidney donor (LKD) evaluation. Iothalamate split scans have been employed during LKD evaluation to document measured…
2020 American Transplant Congress
Deleterious Effect of Intravenous Steroids on Bone Mineral Density in Patients Treated for Borderline Rejection of the Renal Allograft
S. T. Suliman, D. O. Hodge, M. B. Prendergast
Transplant Nephrology, Mayo Clinic, Jacksonville, FL
*Purpose: Subclinical rejection of the renal allograft is known to increase the risk of developing interstitial fibrosis and tubular atrophy which ultimately translates into shortening…
2020 American Transplant Congress
Peritoneal Dialysis in Delayed Graft Function, a Safe and Effective Option
A. Gardezi, B. Muth, F. Aziz, N. Garg, M. Mohamed, A. Djamali, D. Mandelbrot, S. Parajuli
University of Wisconsin, Madison, WI
*Purpose: Peritoneal dialysis (PD) has been utilized increasingly in the past decade. Many of these patients undergo transplantation and may require dialysis for delayed graft…
2020 American Transplant Congress
Bone Marrow Plasma Cell Heterogeneity Drives Resistance of Proteasome Inhibitor Therapy
C. M. Castro-Rojas¹, S. Tremblay², J. Driscoll³, K. Roskin⁴, R. R. Alloway³, E. Woodle², D. A. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH, ²Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, ³Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH
*Purpose: Patients sensitized to HLA antigens by prior transplantation, pregnancy or blood transfusion may have markedly prolonged waiting times for transplant. Moreover, once transplanted, the…
2020 American Transplant Congress
Liver Transplantation with Grafts from Super Obese Donors with a BMI>50
P. Vargas¹, J. M. Cullen¹, P. Northup², J. Oberholzer¹, S. Pelletier¹, N. Goldaracena¹
¹Department of Surgery, Division of Transplantation, University of Virginia Health System, Charlottesville, VA, ²Department of Medicine-Gastroenterology, University of Virginia Health System, Charlottesville, VA
*Purpose: Organ shortage is aggravated by an obesity epidemic. There is limited data on liver transplant (LT) outcomes from liver grafts originating from super obese…