2020 American Transplant Congress
DEPTOR Expression within CD4+Foxp3+ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation
1Boston Children's Hospital, Boston, MA, 2Lavel University, Quebec, QC, Canada
*Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…2020 American Transplant Congress
CD137 Signaling in Regulatory Dendritic Cells Is Required for Suppressing a Systemic Inflammation in the bm12-Inducible Model of Systemic Lupus Erythematosus
*Purpose: Although CD137 is well known as a costimulatory receptor in T cells, limited information is available for its immunoregulatory function. Here, we report that…2020 American Transplant Congress
Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients
*Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…2020 American Transplant Congress
Trends in Living Kidney Donation in the United States
Johns Hopkins University, Baltimore, MD
*Purpose: After peaking in 2014, the number of LKDTs per year dropped substantially in the US despite an increasing waitlist. However, trends in the KAS…2020 American Transplant Congress
Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation
University of Michigan, Ann Arbor, MI
*Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…2020 American Transplant Congress
Thymoglobulin (ATG) Induction vs. Campath vs. Simulect in DCD Kidneys in UK; Induction Regimes Play a Role after All
*Purpose: Controlled DCD kidneys have increased dramatically in UK. They suffer from a higher rate of DGF and, often in UK, come from older donors…2020 American Transplant Congress
Long Term Graft Outcome after Subclinical Banff Borderline Changes Suspicious for Acute T Cell-Mediated Rejection
Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Long term data after Banff borderline changes suspicious for acute T cell-mediated rejection (BDR lesion) are scarce, and hence, there is little evidence to…2020 American Transplant Congress
Short Recipient Warm Ischemia Time Improves Graft Survival in Liver Transplantation from Donation after Brain Death: 20-Year Experience of Liver Transplantation
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: Although the correlation between warm ischemia time (WIT) and the outcomes of liver transplantation has been extensively studied, few investigations have focused on the…2020 American Transplant Congress
Increasing Prevalence and Diversity: Alcoholic Liver Disease in Liver Transplant Candidates
Baylor College of Medicine, Houston, TX
*Purpose: Increasing global alcohol use translates to a marked growth in alcoholic liver disease (ALD). ALD patients comprise a larger proportion of listings for liver…2020 American Transplant Congress
The Effect of Pulsatile Pump Perfusion on Hepatitis C Viremia and Transmission in Kidney Transplantation: A Prospective Pilot Study
1Vanderbilt University Medical Center, Nashville, TN, 2Tennessee Donor Services, Nashville, TN
*Purpose: With increasing utilization of hepatitis C (HCV) viremic donor organs for aviremic recipients, there may be a role for kidney pulsatile pump perfusion to…
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