Am J Transplant, Volume 20, Suppl 3 Archives - Page 114 of 223 - ATC Abstracts

2020 American Transplant Congress
Effects of Donor Specific Antibodies in Intestinal/Multivisceral Transplant Recipients
K. Klein¹, M. Keck², E. Langewisch², S. Merani², M. Leick²
¹University Health System, San Antonio, TX, ²Nebraska Medicine, Omaha, NE
*Purpose: Evaluate the effects of donor specific antibodies (DSAs) on outcomes in post-intestinal/multivisceral (MV) transplant patients and describe the presentation of DSAs post-transplant.*Methods: This single-center…
2020 American Transplant Congress
Donor-Derived DCREG Infusion Prolongs Kidney Allograft Survival in Rhesus Monkeys Treated with Co-Stimulation Blockade and Calcineurin Inhibition
Y. Wang, S. Kazuki, L. Lu, A. Zahorchak, H. Dai, A. Ganoza, M. Wijkstrom, A. Humar, M. Ezzelarab, A. Thomson
Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: We have shown previously that pre-transplantation (Tx) infusion of donor-derived regulatory dendritic cells (DCreg) safely prolongs MHC-mismatched renal allograft survival and regulates donor-reactive T…
2020 American Transplant Congress
Impact of Extended- versus Immediate-Release Tacrolimus on One-Year Development of De Novo DSA and Chronic Immune Activation in Kidney Transplantation (ASTOUND Study)
A. Wiseman¹, D. Kaufman², A. Patel³, D. Wojciechowski⁴, A. Tambur⁵, J. Kim⁶, J. Schwartz⁶
¹University of Colorado Hospital, Aurora, CO, ²University of Wisconsin, Madison, WI, ³Henry Ford Hospital, Detroit, MS, ⁴Massachusetts General Hospital, Boston, MA, ⁵Northwestern University, Chicago, IL, ⁶Astellas Pharma Global Development, Northbrook, IL
*Purpose: To compare, using an adaptive study design, the 1-year incidence of a novel two-part composite endpoint consisting of de novo donor-specific antibody (dnDSA) formation…
2020 American Transplant Congress
Feasibilty of Hepatitis C NAT Positive Kidney Transplant into Hepatitis C Negative Recipients as Standard of Care
T. Kaur, J. Choi, N. Anwar, M. Anand, S. Shah, S. Bumb, B. Abu Jawdeh, S. Shah, T. Diwan, A. Govil
University of Cincinnati Medical Center, Cincinnati, OH
*Purpose: With advent of direct acting antivirals (DAA) for Hepatitis (Hep) C which have a 96-100% sustained viral remission(SVR), doors have opened for using Hep…
2020 American Transplant Congress
Recipient and Donor Factors Associated with Post-Donation ESRD in Related White Living Kidney Donors
J. Wainright¹, A. Robinson¹, A. Wilk¹, D. Klassen², W. Cherikh¹, L. Cartwright¹, D. Stewart¹
¹Research, UNOS, Richmond, VA, ²Chief Medical Officer, UNOS, Richmond, VA
*Purpose: We studied post-donation ESRD in white first-degree related living kidney donors (RLKDs) in the US between 1994 and 2018 (n=45700); this study is the…
2020 American Transplant Congress
Antibodies to Vascular Autoantigens Are Associated with Poor Long-Term Survival of Liver Re-Transplant
Q. Xu¹, V. C. McAlister², S. Leckie², A. A. House², A. Zeevi¹
¹Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Multiorgan Transplant Program, London Health Sciences Centre, London, ON, Canada
*Purpose: Autoantibodies, which may be generated in transplantation through the exposure of cryptic antigens, are reported to be detrimental for allograft survival. We have demonstrated…
2020 American Transplant Congress
Absence of Adverse Infectious Disease Outcomes in the Long-Term Follow-Up of Recipients of PHS Increased Risk Donor Organs: An Essential Tracking Program
L. Irwin, J. Fishman
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: 37-41% of deceased donors in Region I are considered “PHS increased risk for infectious disease transmission” (IR) individuals, our Center developed guidelines for the…
2020 American Transplant Congress
Gingival Mesenchymal Stem Cells (GMSCs) Mitigate Liver Ischemia-Reperfusion Injury by Regulating Macrophage Polarization Through miR-199a-3p
Y. Zhang, M. Chen, W. Ju, T. Wang, Z. Chen, C. Huang, R. Xie, Q. Zhao, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Mesenchymal stromal cells (MSCs) have been increasingly studied in organ ischemia-reperfusion injury, but the mechanism is still unclear. This study explored the immunoregulatory effects…
2020 American Transplant Congress
Lymph Node Stromal Laminin Alpha5 Regulates Antigen Specific T Cell Adaptive Immunity
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, C. Paluskievicz¹, J. Zhao², R. Abdi², J. S. Bromberg¹
¹UMB, Baltimore, MD, ²Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) is associated with immunity and regulates T cell entry and responses within the lymph node (LN). We hypothesized that stromal Lama5…
2020 American Transplant Congress
Simultaneous Heart Kidney Transplant Benefits are Concentrated in the Dialysis Dependent Population
B. I. Shaw¹, M. L. Samoylova¹, Z. W. Fitch¹, M. Bishawi¹, R. Schmitz¹, S. J. Kesseli¹, A. S. Barbas¹, C. B. Patel², S. L. Sanoff², L. M. McElroy¹
¹Surgery, Duke University, Durham, NC, ²Medicine, Duke University, Durham, NC
*Purpose: With ongoing growth of simultaneous organ transplant and increased attention to allocation policy, we examined trends in simultaneous heart-kidney (SHK) transplantation outcomes over the…