Am J Transplant, Volume 19, Suppl 3 Archives - Page 94 of 214 - ATC Abstracts

2019 American Transplant Congress
Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney
S. Noel¹, J. T. Kurzhagen¹, S. Lee¹, M. Sadasivam², A. R. Hamad², P. M. Pierorazio³, H. Rabb¹
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Pathology, Johns Hopkins University, Baltimore, MD, ³Urology, Johns Hopkins University, Baltimore, MD
*Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
2019 American Transplant Congress
IL-21 Induces the Transformation of Th Cell Subsets in Acute Rejection after Kidney Transplantation
H. Deng, R. Wang, J. Shen, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: IL-21 exhibits a wide range of immunomodulatory functions in the organism, regulating immune cells such as B cells and T cells. In this study,…
2019 American Transplant Congress
Allograft Survival is Influenced by Gut Microbiota-Dependent Modulation of Innate Immunity
V. Saxena¹, Y. Xiong¹, L. Hittle¹, L. Li¹, T. Simon², W. Piao¹, C. C. Brinkman¹, E. M. Smyth¹, T. Zhang¹, C. Wagner¹, C. M. Palusckievicz¹, W. F. Fricke³, E. F. Mongodin¹, J. S. Bromberg¹
¹U Maryland, Baltimore, MD, ²Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, CNRS, Valbonne, France, ³Institute of Biological Chemistry and Nutrition, U Hohenheim, Stuttgart, Germany
*Purpose: The gut microbiota driven inflammatory response and the host immune system engage bidirectional regulation of each other. These interactions are poorly characterized in organ…
2019 American Transplant Congress
Inhibition of Sialidase Activity and Galectin Binding Reduces Xenogeneic Neutrophil-Endothelial Adhesion
B. M. Cerel¹, B. M. French², D. G. Harris², C. Laird², L. Burdorf¹, X. Cheng², C. Feng³, A. S. Cross⁴, S. E. Goldblum⁴, G. R. Vasta³, R. N. Pierson III¹, A. M. Azimzadeh¹
¹Deparment of Surgery, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, ³Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, MD, ⁴Department of Medicine Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD
*Purpose: Immediate neutrophil sequestration occurs despite genetic modifications (Gal-a-1-3 galactosyl transferase knock out; human CD46 complement regulatory gene addition) to pig donor organs. Sialic acids…
2019 American Transplant Congress
De Novo Complement-Activating Donor Specific Antibodies in Pediatric Renal Transplant Recipients Are Highly Responsive to Therapy
V. Sigurjonsdottir, A. Chaudhuri, P. Grimm
Pediatric Nephrology, Stanford, Los Altos, CA
*Purpose: Antibody mediated rejection remains a common cause for pediatric renal allograft loss. After recognizing that graft failure was more common in our pediatric renal…
2019 American Transplant Congress
Regional Disparities In The Transplant Rates Across Unos Regions Pre- And Post-kidney Allocation System Policy Implementation
A. C. Perez-Ortiz, E. Heher, N. Elias
Massachusetts General Hospital, Boston, MA
*Purpose: Geographic distribution of organs for transplant is a critical component of the Organ Procurement and Transplantation Network (OPTN) policies. However, there is no single…
2019 American Transplant Congress
Safety and Efficacy of Imlifidase in Highly-Sensitized Kidney Transplant Patients: Results from a Phase 2 Study
S. C. Jordan¹, C. Legendre², N. Desai³, T. Lorant⁴, M. Bengtsson⁴, L. Laxmyr⁵, B. Lonze⁶, A. Vo¹, K. J. Wood⁷, C. Kjellman⁵, R. A. Montgomery⁶
¹Cedars-Sinai Medical Center, Los Angeles, CA, ²Hopital Necker, Paris, France, ³Johns Hopkins University, Baltimore, MD, ⁴Uppsala University, Uppsala, Sweden, ⁵Hansa Medical AB, Lund, Sweden, ⁶NYU Langone Health Transplant Institute, New York, NY, ⁷University of Oxford, Oxford, United Kingdom
*Purpose: Many patients eligible for kidney transplantation are sensitized to allo-HLA antigens and face prolonged waiting times and increased mortality. The presence of donor specific…
2019 American Transplant Congress
Early Tacrolimus Trough Concentration Variability Could Predict Rejection in Pediatric Liver Transplantation: A Single-Center and Retrospective Research
G. Gu, Q. Xia
Renji Hospital, Shanghai, China
*Purpose: With great development in immunosuppressive therapy, the long-term outcomes and survival time in patients who received solid organ transplantation have been improved remarkably. The…
2019 American Transplant Congress
Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants
S. Cohen, S. Partouche, M. Gurevich, V. Mezhybovsky, V. Tennak, S. Eisner, E. Nesher, E. Mor
Rabin Medical Center, Petah-Tiqwa, Israel
*Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…
2019 American Transplant Congress
Sirna Uptake During Ex Vivo Hypothermic And Normothermic Liver Machine Perfusion: Beginning Of A New Era Of Organ Preservation
A. Gillooly¹, C. Moore¹, J. Perry¹, I. Bruggenwirth², M. Thijssen², X. Wang¹, X. E¹, P. Mandrekar¹, T. Kowalik¹, R. Porte², H. Leuvenink², R. Abdi³, A. Bozorgzadeh¹, P. N. Martins¹
¹University of Massachusetts Medical School, Worcester, MA, ²University of Groningen, Groningen, Netherlands, ³Brigham and Women's Hospital, Boston, MA
*Purpose: RNA interference (RNAi) is a natural gene modulation process that was recently approved for clinical use and has great potential for treatment of many…