Am J Transplant, Volume 19, Suppl 3 Archives - Page 94 of 214 - ATC Abstracts

2019 American Transplant Congress
Engineering Regulatory T Cells With TCR-Signaling-Responsive Interleukin 2 Nanoparticles Provides In Situ Suppression Of Alloimmunity
S. K. Eskandari¹, M. B. Melo², I. Sulkaj¹, N. Li², S. Cai¹, H. Allos¹, J. Y. Choi¹, D. J. Irvine², J. R. Azzi¹
¹Harvard Medical School, Brigham and Women's Hospital, Boston, MA, ²David H. Koch Institute for Integrative Cancer Research, Cambridge, MA
*Purpose: Adoptive cell transfer of regulatory T cells (TReg) has shown great potential in animal models of auto- and alloimmunity. The translation of TReg therapies…
2019 American Transplant Congress
Development of a Pharmacy Collaborative Practice Agreement to Improve Efficiency and Management of Prescribing in a Renal Transplant Clinic
R. Chelewski¹, K. Johnson¹, A. Zuckerman², J. DeClercq³, L. Choi³, M. Peter², A. J. Langone⁴
¹Vanderbilt Specialty Pharmacy Services, Vanderbilt Univ Medical Ctr, Nashville, TN, ²Department of Pharmacy, Vanderbilt Univ Medical Ctr, Nashville, TN, ³Department of Biostatistics, Vanderbilt Univ Medical Ctr, Nashville, TN, ⁴Division of Nephrology, Vanderbilt Univ Medical Ctr, Nashville, TN
*Purpose: This study describes the development of a Collaborative Pharmacy Practice Agreement (CPPA) between transplant pharmacists and physicians and assesses change in prescription volume and…
2019 American Transplant Congress
Three-Year Outcomes of Highly-Sensitized Kidney Transplant Recipients Desensitized with Imlifidase (IdeS)
E. Huang¹, J. Choi¹, A. Vo¹, A. Peng¹, R. Najjar¹, S. Sethi¹, C. Kjellman², L. Winstedt², N. Ammerman¹, S. C. Jordan¹
¹Cedars Sinai Medical Center, Los Angeles, CA, ²Hansa Medical, Lund, Sweden
*Purpose: The HLA-incompatible (HLAi) barrier has been traversed using desensitization therapies with IVIg, rituximab and/or plasmapheresis, although antibody-mediated rejection (ABMR) continues to be observed in…
2019 American Transplant Congress
Effect of Chronic Kidney Disease on Allo-Immune Response in Mice
P. D. Winterberg¹, H. Li¹, M. E. Wagener², M. L. Ford²
¹Pediatrics, Emory University School of Medicine, Atlanta, GA, ²Surgery, Emory University School of Medicine, Atlanta, GA
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). However, mouse models…
2019 American Transplant Congress
In Vitro Model to Study the Effect of Irradiation Preconditioning on Alloimmune Responses: Development of Potential Predictive Markers
K. Shimozawa, K. Janec, L. Contreras-Ruiz, E. C. Guinan
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Pre-conditioning using total body irradiation prior to HSCT is a well-established regimen for patients with hematological malignancy. However, irradiation (IR) elicits not only immunosuppressive…
2019 American Transplant Congress
Development of Non-Human Leukocyte Antigen Antibodies in Cardiac Antibody-Mediated Rejection
S. B. See¹, B. S. Mantell², K. J. Clerkin³, B. Ray⁴, E. R. Vasilescu⁵, C. Marboe⁵, Y. Naka⁶, S. Restaino¹, P. C. Colombo³, L. J. Addonizio², M. A. Farr³, E. Zorn¹
¹Columbia Center for Translational Immunology, Columbia University, New York, NY, ²Department of Pediatrics, Columbia University, New York, NY, ³Division of Cardiology, Columbia University, New York, NY, ⁴Immucor, Georgia, GA, ⁵Department of Pathology and Cell Biology, Columbia University, New York, NY, ⁶Department of Surgery, Columbia University, New York, NY
*Purpose: Antibody-mediated rejection (AMR), mainly driven by the development of donor-specific antibodies (DSA) directed against mismatched donor class I and class II HLA, is a…
2019 American Transplant Congress
Efficacy of Photobiomodulatory Therapy Combined with Short-Term Immunosuppressants Prolonged Allograft Survival in a Rodent Hind-Limb Model
Y. KUO¹, Y. Li¹, C. Chen¹, R. Chen1¹, G. Brandacher²
¹Division of Plastic Surgery, Department of Surgery,, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ²Department of Plastic Surgery, VCA center, Johns Hopkins University, Baltimore, MD
*Purpose: Photobiomodulation has been applied for accelerating the skeletal muscle repair process. Our formal study demonstrated vitamin D could be involved in allograft survival and…
2019 American Transplant Congress
Uterine Graft Procurement in a Living Donor
L. Johannesson, A. Wall, J. Bayer, G. J. McKenna, G. Testa
Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
*Purpose: Uterus transplantation is a new treatment option for females with uterine factor infertility and a rapidly evolving field of organ transplantation. Proof-of-concept, i.e., birth…
2019 American Transplant Congress
Alpha-1 Antitrypsin Reduces Liver Ischemia Reperfusion Injury during Ex-Vivo Normothermic Machine Perfusion
D. Detelich¹, R. de Vries¹, C. Carroll¹, M. Stein², K. Uygun¹, H. Yeh¹, J. Markmann¹
¹Massachusetts General Hospital, Boston, MA, ²Kamada, Rehovot, Israel
*Purpose: Normothermic machine perfusion is an emerging preservation method in liver transplantation with vast potential as a platform for ex-vivo graft reconditioning. Alpha-1 Antitrypsin (AAT)…
2019 American Transplant Congress
Multi-omic Analysis Of Hepatic Ischemia/reperfusion Injury Identifies Novel Targets To Mitigate Hepatocellular Damage
S. Duarte¹, V. Boominathan², Z. Huo³, A. Kobayashi², U. Kim², Y. Lai², A. Coito¹, A. Zarrinpar²
¹Surgery, UCLA, Los Angeles, CA, ²Surgery, University of Florida, Gainesville, FL, ³Biostatistics, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major risk factor for acute rejection and early graft dysfunction in liver transplantation. The large and complex landscape…