ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Exosomes Carry Stress and Damage Specific miRNAs during Peritransplant Period in TPIAT

    P. Saravanan1, M. Kanak1, S. Vasu2, M. Lawrence2, M. Levy1, B. Naziruddin3

    1Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, 2Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, 3Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX

    *Purpose: Innate inflammation and hypoxia during peritransplant period significantly affect survival of islet grafts. Markers that can identify stress and/or damage during this early period…
  • 2019 American Transplant Congress

    Use Of Perirenal Adipose Tissue As A Source Of Donor Cells Allowing Evaluation Of Endothelial Inflammation And Quality Of Expanded Criteria Kidneys

    R. Boissier1, L. Lyonnet2, P. Francois3, M. Meunier4, B. Gondran-Tellier5, T. Legris6, J. Magalon5, C. Picard7, F. Dignat George5, E. Lechevallier8, G. Karsenty8, F. Sabatier9, P. Paul1

    1INSERM 1263, Centre de recherche en cardiovasculaire et nutrition, INSERM, Aix Marseille Univ, Assistance Publique Hopitaux Marseille, Marseille, France, 2Vascular Biology and Hematology department, Assistance publique Hopitaux Marseille (AP-HM), Marseille, France, 3INSERM 1263, Centre de recherche en cardiovasculaire et nutrition, INSERM, Aix Marseille Univ., Marseille, France, 4Nephrology Dialysis and Renal Transplantation Center, AP-HM, Marseille, France, 5INSERM 1263, C2VN, INSERM, Aix Marseille Univ., Marseille, France, 6Nephrology Dialysis and Renal Transplantation Center, AP-HM, Marseille, France, 7Etablissement Français du Sang, Alpes Méditerranée, Marseille, France, 8Urology and Transplantation Unit , AP-HM, Marseille, France, 9INSERM 1263, Centre de recherche en cardiovasculaire et nutrition, INSERM, Aix Marseille Univ, Marseille, France

    *Purpose: Use of expanded-criteria donor (ECD) kidneys is a perspective to overcome organ shortage. Age and donor-related co-morbidy factors are known to affect graft function…
  • 2019 American Transplant Congress

    Application of Small Molecule Fluorescent Probes in Early Activation Imaging of CD8+ T Lymphocytes

    P. Rong, X. Zhou

    Central South University, The Third Xiangya Hospital, Changsha, China

    *Purpose: As a subset of T lymphocytes, CD8+ T lymphocytes play a vital role in the body's immune system.CD8+ T lymphocytes are responsible for the…
  • 2019 American Transplant Congress

    Hepatoblastoma Tumors Requiring Liver Transplantation Manifest Dysregulated Ciliary, Autophagy and Cell Cycling Pathways in Systems Biology Analysis

    T. Narayanan1, M. Ningappa2, B. W. Higgs2, S. Subramaniam3, R. Sindhi2

    1Bioenginering, University of California, San Diego, CA, 2Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 3University of California, San Diego, CA

    *Purpose: Liver transplantation (LT) can cure locally invasive, unresectable and chemo-resistant hepatoblastoma (HBL), an embryonal liver tumor of infancy. Post-LT immunosuppression enhances recurrence-risk despite chemotherapy.*Methods:…
  • 2019 American Transplant Congress

    Automated Histology Lesion Interpretation in Kidney Transplant Biopsies Shows That Pathologists Often Deviate from Banff Guidelines

    K. S. Madill-Thomsen1, J. Reeve2, G. Bohmig3, F. A. Eskandary4, A. Perkowska-Ptasinska5, M. Myslak6, P. F. Halloran and the INTERCOMEX Study Group1

    1University of Alberta, Edmonton AB, AB, Canada, 2Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 3Medical University of Vienna, Vienna, Austria, 4Medical University of Vienna, Edmonton AB, AB, Canada, 5Medical University of Warsaw, Warsaw, Poland, 6Pomeranian Medical University, Szczecin, Poland

    *Purpose: Histologic diagnosis of kidney transplant biopsies requires an expert pathologist using Banff guidelines to interpret features. Some problematic guidelines require experts to use professional…
  • 2019 American Transplant Congress

    Single Center Deceased Donor Renal Transplant (DDRTx) Outcomes in Sensitized Patients after Implementation of the Kidney Allocation System (KAS)

    S. S. Patel, K. L. King, J. Kamal, E. Vasilescu, A. Husain, S. Mohan, L. E. Ratner, R. Crew

    Columbia University Irving Medical Center, New York, NY

    *Purpose: Introduction of KAS in 2014 prioritized access to DDRTx for highly-sensitized candidates although it was unclear whether the outcomes would be acceptable in this…
  • 2019 American Transplant Congress

    Risk of Delayed Graft Function after Deceased Donor Kidney Transplantation in the Current Era

    I. Helanterä1, H. N. Ibrahim2, M. Lempinen1, P. Finne3

    1Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland, 2Department of Medicine, Houston Methodist Hospital, Houston, TX, 3Nephrology, Helsinki University Hospital, Helsinki, Finland

    *Purpose: Delayed graft function (DGF) is associated with morbidity and cost after deceased donor kidney transplantation. Some data suggest that previously sensitized patients and kidneys…
  • 2019 American Transplant Congress

    Early Conversion to Belatacept in High Risk Renal Transplant Recipients

    A. Santeusanio, A. Bhansali, R. Shapiro, V. Delaney, S. Florman, G. De Boccardo

    Mount Sinai Hospital, New York, NY

    *Purpose: This study describes our experience with early conversion to belatacept therapy in a diverse patient population including patients with donor specific antibodies (DSA). The…
  • 2019 American Transplant Congress

    Conversion to Belatacept in Kidney Transplant Recipients with Systemic Lupus Erythematosus

    I. Carrión Barberà, M. C. Fajardo, D. Tsapepas, J. Gartshteyn, A. Askanase, H. E. Fernandez

    Columbia University MC, New York, NY

    *Purpose: Lupus nephritis (LN) results in the need for renal replacement therapy (RRT) in 10-30% of LN pts and 30% receive a kidney transplant (KT).…
  • 2019 American Transplant Congress

    Sirolimus (SRL) versus Everolimus (EVR) versus Mycophenolate (MPA) in Kidney Transplant Recipients Receiving Anti-Thymocyte Globulin Induction (r-ATG), Tacrolimus (TAC), and Prednisone

    C. Rosso Felipe, L. Viana, M. Pontello Cristelli, J. Toniato, K. Ficher, S. Poletto, H. Proença, R. de Marco, M. Gerbase-Lima, A. Brigido, J. Medina Pestana, H. Tedesco-Silva

    Hospital do Rim, Nephrology Division, EPM - UNIFESP, São Paulo, Brazil

    *Purpose: TAC and MPA combination is considered the standard of care immunosuppressive regimen in the majority of transplant centers worldwide. Yet, given the lack of…
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