Am J Transplant, Volume 19, Suppl 3 Archives - Page 87 of 214 - ATC Abstracts

2019 American Transplant Congress
Combined Ischemic and Rapamycin Preconditioning Alleviated Liver Ischemia and Reperfusion Injury by Restoring Autophagy in Old Mice
Z. Rao, X. Pan, W. Zhong, Z. Ding, H. Zhou, C. Liu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the…
2019 American Transplant Congress
Pgc1α Protects against Graft Ischemic Injury and Reduces Alloimmunity
T. J. Borges¹, M. T. Tran², S. Cai¹, N. Murakami¹, A. Uffing¹, M. Uehara¹, E. P. Rhee³, S. M. Parikh⁴, L. V. Riella¹
¹Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Nephrology Division, Massachusetts General Hospital, Boston, MA, ⁴Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
*Purpose: Prolonged ischemia reperfusion injury (IRI) during organ transplantation activates innate immunity and potentiates adaptive immunity, leading to worse transplant outcomes. The mitochondria are particularly…
2019 American Transplant Congress
Donor Management in Donation after Brain Death: A Window of Opportunity – Are Pro-Inflammatory Mediators the Target and What is the Effect of Duration of Brain Death?
K. D. Bera¹, J. Tabak², M. L. Lo Faro¹, R. J. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University of Exeter, Exeter, United Kingdom
*Purpose: Donation after brain death (BD) is a crucial source of transplanted organs - uncertainty remains how duration of BD contributes to outcomes: This study…
2019 American Transplant Congress
The Number of Donor-Specific IL-21 Producing Cells before and after Transplantation Predicts Kidney Graft Rejection
N. M. van Besouw¹, L. Yan¹, R. de Kuiper¹, M. Klepper¹, D. Reijerkerk¹, M. Dieterich¹, D. L. Roelen², F. H. Claas², M. C. Clahsen-van Groningen³, D. A. Hesselink¹, C. C. Baan¹
¹Internal Medicine - Nephrology & Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands, ³Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
*Purpose: Interleukin (IL)-21 supports induction and expansion of CD8+ T cells, and can also regulate the differentiation of B cells into antibody-producing plasma cells. We…
2019 American Transplant Congress
High Prevalence of Allergic Disorders but No Specific Immune Phenotype Pattern in Children Awaiting Transplantation
T. B. Kim¹, Y. Avitzur², L. Ionescu¹, U. Allen², S. Mital², B. Foster³, T. Blydt-Hansen⁴, L. Hamiwka⁵, P. Birk⁶, V. Phan⁷, S. Urschel¹
¹University of Alberta, Edmonton, AB, Canada, ²Hospital for Sick Children, Toronto, ON, Canada, ³McGill University, Montreal, QC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵University of Calgary, Calgary, AB, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷Université de Montréal, Montreal, QC, Canada
*Purpose: Allergic disorders (AD) occur more frequently in children after transplantation (Tx) compared to healthy children, reflecting an imbalance of the immune system in the…
2019 American Transplant Congress
Multi-Center Validation of TruGraf V2 – A Peripheral Blood Diagnostic for Subclincal Kidney Rejection
C. Marsh¹, S. Kurian¹, C. Schieve², R. Heilman³, M. Stegall⁴, S. Rose², J. Case¹, J. Friedewald⁵, M. Abecassis⁵, R. First²
¹Scripps Health, La Jolla, CA, ²Transplant Genomics Inc., Mansfield, MA, ³Mayo Clinic, Scottsdale, AZ, ⁴Mayo Clinic, Rochester, MN, ⁵Northwestern University, Chicago, IL
*Purpose: Unsuspected subclinical acute rejection (subAR) is currently only detectable in 15-25% of invasive surveillance biopsies (SB) and can lead to chronic rejection and poor…
2019 American Transplant Congress
Influence Of HLA-DR Mismatches On Long Term Outcomes Following Heart Transplantation
A. Singhvi, R. Araujo-Gutierrez, M. H. Park, A. Bhimaraj, B. H. Trachtenberg, I. Hussain, A. Guha
Division of Cardiology/ JC Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: In the field of kidney transplantation, there is strong support for the beneficial effect of minimizing donor-recipient HLA incompatibility, and HLA-DR matching in particular…
2019 American Transplant Congress
Room for Improvement: Adherence to Vaccination Recommendations in a Heart Transplant Cohort
D. Jandhyala, J. D. Lewis
Medical University of South Carolina, Charleston, SC
*Purpose: Vaccination of solid organ transplant (SOT) candidates and recipients is vital to decrease infection-related morbidity and mortality. However, published reports have shown that adherence…
2019 American Transplant Congress
Predictors of Glomerular Filtration Rate after Renal Transplantation
O. Andacoglu, Y. Dong, J. Liu, M. Parides, J. Rocca, J. Graham, M. Ajaimy, Y. Azzi, C. Pynadath, L. Liriano-Ward, M. Kinkhabwala, E. Akalin, S. Greenstein
Montefiore Medical Center, Bronx, NY
*Purpose: Glomerular filtration rate (GFR) is an excellent indicator of renal function however there is limited data on the impact of KDPI on long term…
2019 American Transplant Congress
Effect of HLA Mismatch on Recurrence and Graft Loss in Living versus Deceased Kidney Transplant Recipients with IgA Nephropathy
T. Ishaque, F. A. Ammary, K. Jackson, D. L. Segev, A. B. Massie
Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: A registry based study from Australia and New Zealand reported increased risk of recurrent IgA nephropathy (IgAN) in zero-HLA-mismatched living donor kidney transplant (LDKT)…