ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Three-Year Outcomes of Highly-Sensitized Kidney Transplant Recipients Desensitized with Imlifidase (IdeS)

    E. Huang1, J. Choi1, A. Vo1, A. Peng1, R. Najjar1, S. Sethi1, C. Kjellman2, L. Winstedt2, N. Ammerman1, S. C. Jordan1

    1Cedars Sinai Medical Center, Los Angeles, CA, 2Hansa Medical, Lund, Sweden

    *Purpose: The HLA-incompatible (HLAi) barrier has been traversed using desensitization therapies with IVIg, rituximab and/or plasmapheresis, although antibody-mediated rejection (ABMR) continues to be observed in…
  • 2019 American Transplant Congress

    Effect of Chronic Kidney Disease on Allo-Immune Response in Mice

    P. D. Winterberg1, H. Li1, M. E. Wagener2, M. L. Ford2

    1Pediatrics, Emory University School of Medicine, Atlanta, GA, 2Surgery, Emory University School of Medicine, Atlanta, GA

    *Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). However, mouse models…
  • 2019 American Transplant Congress

    Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy

    M. V. Habal1, A. Myung2, H. Yan2, S. Rao2, S. Lin2, S. See2, P. Roy2, R. Shihab2, C. Marboe3, S. Restaino1, A. Han2, M. Givertz4, J. C. Madsen5, L. Addonizio1, M. Farr1, E. Zorn2

    1Cardiology, Columbia University Medical Center, New York, NY, 2Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, 3Pathology, Columbia University Medical Center, New York, NY, 4Cardiology, Brigham and Women's Hospital, Boston, MA, 5Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…
  • 2019 American Transplant Congress

    JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively

    H. Xu1, A. Merchak1, J. Xu2, Y. Huang1, S. T. Ildstad1

    1University of Louisville, Institute for Cellular Therapeutics, Louisville, KY, 2DuPont Manual High School, Louisville, KY

    *Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…
  • 2019 American Transplant Congress

    Mechanical Irritation in Vascularized Tissue Allotransplantation Triggers Localized Skin Rejection

    F. Messner, A. Fischer, E. Runggaldier, S. Eiter, B. Zelger, B. Zelger, S. Sprung, D. Öfner, S. Schneeberger, T. Hautz

    Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria

    *Purpose: “Atypical” forms of skin rejection have been described in some hand transplanted patients mainly manifesting on the palm including dryness, scaling and thickening of…
  • 2019 American Transplant Congress

    Immunosuppression after Organ Transplantation Does Not Enhance Patency of Cold-Stored Vein Allografts for Critical Limb Ischemia -Single Centre Experience

    J. Chlupac, T. Marada, R. Novotny, K. Lipar, L. Janousek, J. Fronek

    Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

    *Purpose: Sub-inguinal bypass with cold-stored saphenous vein allograft is a last option treatment for extensive peripheral arterial occlusive disease with absent autologous vein. The aim…
  • 2019 American Transplant Congress

    Randomized Controlled Trial Of Spironolactone Effect In Kidney Transplant Recipients Of Living Donors

    N. A. Bobadilla1, L. E. Morales-Buenrostro1, J. A. Ortega-Trejo1, R. Perez-Villalva1, L. Marino1, Y. González-Bobadilla1, H. Juarez1, F. Zamora-Mejía1, N. Gonzalez1, R. Espinoza2, J. Barrera-Chimal3

    1Nephrology, INCMNSZ, Mexico City, Mexico, 2Nephrology, Centro Médico Nacional Siglo XXI, Mexico City, Mexico, 3Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico

    *Purpose: Mineralocorticoid receptor antagonism prevents acute kidney injury induced by ischemia/reperfusion in rodent and pig preclinical models. In a pilot study, we showed that spironolactone…
  • 2019 American Transplant Congress

    CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury

    C. Akateh1, B. F. Reader1, Y. Lee1, J. Kim1, K. Maynard1, K. W. Washburn1, J. L. Zweier2, B. A. Whitson1, S. M. Black1

    1Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 2The Ohio State University Wexner Medical Center, Columbus, OH

    *Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…
  • 2019 American Transplant Congress

    Improvement of the Outcome of Clinical Islet Transplantation Depending on the Era in Japan

    Y. Akashi1, T. Kenmochi2, T. Ito3, K. Kurihara2, N. Aida2, A. Kawai2, M. Hayashi4, K. Kouketsu4

    1Faculty of Nursing, School of Health Sciences, Fujita Health University, Toyoake, Japan, 2Department of Transplantation and Regenerative Medicine, Fujita Health University, Toyoake, Japan, 31 Department of Transplantation and Regenerative Medicine,, Fujita Health University, Toyoake, Japan, 4Transplant medical support office, Fujita Health University Hospital, Toyoake, Japan

    *Purpose: Islet transplantation (ITX) is an ideal treatment for type 1 diabetic patients. In this paper, we compared the outcome of ITX depending on Era…
  • 2019 American Transplant Congress

    Evaluating Adherence to Immunosuppressive Drugs through Trackyourmed® an Innovative Qr Code-Scanner App in Renal Transplantation: Preliminary Results from i-COM Trial

    E. Melilli1, M. Meneghini1, N. Montero1, A. Coloma1, I. Revuelta2, F. Moreso3, V. Torregrosa2, J. Grinyo1, O. Bestard1

    1Renal Transplant Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain, 2Renal Transplant Unit, Hospital Clinic, Barcelona, Spain, 3Renal Transplant Unit, Vall D'Hebron Hospital, Barcelona, Spain

    *Purpose: Low adherence to chronic immunosuppressive (IS) drugs has been recognized as a major cause of premature graft loss. Although erratic trough blood IS levels…
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