Am J Transplant, Volume 19, Suppl 3 Archives - Page 80 of 214 - ATC Abstracts

2019 American Transplant Congress
Anti-Donor M H C Class I I Alloantibody Induce Glomerular Injury in Mouse Renal Allografts Subjected to Prolonged Cold Ischemia
V. Gorbacheva, R. Fan, A. Beavers, R. Fairchild, W. Baldwin, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury.The goal of this study…
2019 American Transplant Congress
The Burden of Recipient Driving Distance and Post Lung Transplant Outcomes: A National Cohort Study
W. Tsuang, S. Arrigain, R. Lopez, M. Snair, K. McCurry, M. Budev, J. Schold
Cleveland Clinic, Cleveland, OH
*Purpose: There are only 75 lung transplant centers in the United States, which leads to a spectrum of travel burdens among patients in order to…
2019 American Transplant Congress
Epitop Matching Predicts Immunization in Kidney Transplant Recipients with Allograft Failure Leading to Worse Outcomes
F. Halleck¹, M. Merkel¹, P. Bach², D. Schmidt¹, M. Niemann³, N. Lachmann⁴, K. Budde¹
¹Nephrology, Charite, Berlin, Germany, ²Institute of Biometry and Clinical Epidemiology, Charite, Berlin, Germany, ³PIRCHE AG, Berlin, Germany, Berlin, Germany, ⁴Institute for Transfusion Medicine, H&I Laboratory, Charite, Berlin, Germany
*Purpose: The number of immunized patients on the waitlist is increasing worldwide. There is a lack of data about the impact of immunization after transplantation…
2019 American Transplant Congress
Impact Of Cold And Warm Ischemia Time On Outcomes For Kidneys Donated After Cardiac Death
C. Brennan¹, P. R. Sandoval², S. A. Husain², D. Tsapepas¹, S. Mohan², L. E. Ratner²
¹New York Presbyterian, New York, NY, ²Columbia University Medical Center, New York, NY
*Purpose: Donors after cardiac death (DCD) organs are frequently being discarded. Prolonged warm (WIT) cold (CIT) ischemia times are often important considerations in the discard…
2019 American Transplant Congress
Spontaneous Bacterial Peritonitis Prophylaxis Increases the Risk of Multi-Drug Resistant Cultures and Infections in Liver Transplant Patients
R. Rosenblatt, A. Schluger, M. Pereira, E. Verna
Columbia University Medical Center, New York, NY
*Purpose: Spontaneous bacterial peritonitis prophylaxis (SBP-P) is increasingly prescribed to patients awaiting liver transplantation (LT), but its impact on multidrug resistant organisms (MDRO) or the…
2019 American Transplant Congress
Prolongation of Allograft Survival via Donor MHC Chimerism Induced by Exosomes
B. Gonzalez Nolasco¹, M. Wang¹, W. Orent¹, A. Prunevieille¹, J. O¹, K. Ahrens¹, J. C. Madsen², G. Benichou¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Achieving robust and durable host immune tolerance of allogeneic transplants is the ultimate goal in clinical transplantation. Mixed chimerism induced via donor bone marrow…
2019 American Transplant Congress
Progress Using Genetically Engineered Pigs for Lung Xenotransplantation
L. Burdorf¹, C. Laird², S. Sendil², T. Zhang², D. Parsell², I. Tatarov², B. Cerel¹, Z. Abady¹, S. Pratts¹, C. J. Phelps³, D. L. Ayares³, A. M. Azimzadeh¹, R. N. Pierson III¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Surgery, University of MD, Baltimore, MD, ³Revivicor, Blacksburg, VA
*Purpose: CRISPR/Cas9 gene editing techniques facilitate generation of pigs with multiple genetic modifications. We report results associated with multiple mechanistically targeted gene knock-outs and transgenes,…
2019 American Transplant Congress
OPO Aggressiveness Index: A Novel OPO Performance Metric That Incentivizes Pursuit of Marginal Deceased Donor Candidates
L. Liyanage, Y. Yu, K. Jackson, J. Garonzik-Wang, D. Segev, A. Massie
Johns Hopkins, Baltimore, MD
*Purpose: Of 2.5M deaths in the US every year, only 10,000 are recovered for transplantation; recovery of organs from older donors is rare although similar…
2019 American Transplant Congress
Geographic Disparities in Heart Transplant Rates
M. Kosztowski, S. Yu, A. Kilic, A. Massie, S. Zhou, D. Segev, S. Gentry
JHU, Baltimore, MD
*Purpose: One of the motivations for the recent changes to the heart allocation policy was to reduce geographic disparities. We investigated whether heart transplant (HT)…
2019 American Transplant Congress
Clazakizumab (CLZ, Anti-IL-6 Antibody) and Tocilizumab (TCZ, Anti-IL-6 Receptor [r] Antibody) Treatments Differentially Affect IL-6/IL-6R Signaling by Modulating Soluble IL-6R (sIL-6R) and gp130 (sgp130) in Kidney Transplant Patients (KTx Pts) Treated for Chronic Antibody-Mediated Rejection (cABMR)
B. Shin, S. Ge, A. Petrosyan, N. F. Ammerman, A. A. Vo, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: We have reported successful use of TCZ for cABMR treatment in HLA-sensitized KTx Pts. CLZ is 3-120 times more potent than TCZ in IL-6/IL-6R…