Am J Transplant, Volume 19, Suppl 3 Archives - Page 80 of 214 - ATC Abstracts

2019 American Transplant Congress
Organ Vigilance in Germany: Malignancy Transmission from Organ Donor to Recipient
K. Moench, A. Rahmel, A. P. Barreiros
German Foundation for Organtransplantation, Frankfurt, Germany
*Purpose: Vigilance monitoring after organ transplantation includes Serious Adverse Events (SAE) and Serious Adverse Reactions (SAR). SAE describe findings in the donor after transplant that…
2019 American Transplant Congress
Mismatched Antibody Epitopes and the Development of HLA-DQ De Novo DSA during Immunosuppression Withdrawal in Liver Transplant Recipients
V. Jucaud¹, A. Shaked², M. DesMarais³, P. Sayre⁴, S. Feng⁴, J. Levitsky⁵, M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²University of Pennsylvania, Philadelphia, PA, ³Immune Tolerance Network, San Francisco, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵Northern Western University, Chicago, IL
*Purpose: We recently described, in liver transplant (LT) recipients from the ITN030ST study, the development of de novo donor-specific HLA antibodies (dnDSA) and their impact…
2019 American Transplant Congress
Supercooling Preservation Prolonged Mouse Cardiac Graft Cold Ischemia Time
W. Que¹, X. Hu¹, M. Fujino¹, Y. Yamada², L. Zhong³, X. Li¹
¹Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan, ²Technican Co., Ltd., Kanagawa, Japan, ³Department of Surgery, Shanghai General Hospital, shanghai Jiao Tong University School of Medicine, Shanghai, China
*Purpose: Supercooling preservation techniques store a donor organ below 0°C without freezing. This has great advantages in inhibiting metabolism and preserving the organ in comparison…
2019 American Transplant Congress
Renal Cell Carcinoma in Dialysis Patients: Criteria for Transplant Wait List Inclusion
D. B. Laskar¹, J. Zeng¹, S. Sharma², M. T. Smith Jr³, A. D. Nicastri¹, D. Levitan⁴, R. Maglantay¹, D. John³, S. R. Gottesman¹
¹Pathology, SUNY Downstate Medical Center, Brooklyn, NY, ²Transplant Surgery, NYP/Columbia University Medical Center, New York, NY, ³Surgery, SUNY Downstate Medical Center, Brooklyn, NY, ⁴Pathology & Laboratory Medicine, NYP/Weill Cornell Medical Center, New York, NY
*Purpose: End-stage renal disease (ESRD) patients on long-term hemodialysis have a higher incidence of renal cell carcinoma (RCC) in their native kidneys than the general…
2019 American Transplant Congress
Associations between State-Level Donor Designation Rate and Organ Procurement Organization Characteristics and Outcomes
J. Bragg-Gresham¹, P. Held², J. P. Roberts³
¹Kidney Epidemiology and Cost Center, Univ of Michigan, Ann Arbor, MI, ²Stanford University, Stanford, CA, ³University of California San Francisco, San Francisco, CA
*Purpose: The impact of “Donor Designation (DDSR)”, a pledge to donate with state drivers licensing authority, has not been explored. This work focusses on estimating…
2019 American Transplant Congress
In Vivo/In Situ Behaviour of Allogeneic Spleen versus Bone Marrow Cells in Wild-Type Neonatal Mice: Insights into Robust Transplant Tolerance Induction
R. A. Bascom, K. Tao, L. J. West
Pediatrics, University of Alberta, Edmonton, AB, Canada
*Purpose: Comparing the behaviour of fully allogeneic spleen (SC) vs bone marrow cells (BMC) in non-conditioned neonatal mice is important for maximizing synergistic interactions between…
2019 American Transplant Congress
ECDI-Treated Donor Leukocytes in Primate Cardiac Allograft Recipients
Z. Alikhassy Habibabady¹, T. Zhang², W. Sun², X. Cheng², L. Burdorf¹, I. Tatarov², S. Sendil², I. Behroozfard², B. Cerel¹, D. Parsell², R. N. Pierson III¹, X. Luo³, A. M. Azimzadeh¹
¹Surgery, Massachusetts General Hospital and Harvard School of Medicine, Boston, MA, ²Surgery, University of Maryland School of Medicine, Baltimore, MD, ³Duke Transplant Center, Duke University, Durham, NC
*Purpose: Ethyl carbodiimide (ECDI)-fixed donor leukocytes exhibit tolerogenic immunomodulation in murine models of autoimmunity and transplantation, and nonhuman primate islet transplantation. Here in pilot studies…
2019 American Transplant Congress
TMA Development in Kidney and Heart Xenografts Treated with Anti-CD40 or Anti-CD154 Antibodies
D. H. Ma¹, H. Sasaki¹, J. M. O¹, K. Ahrens¹, D. Becerra¹, C. G. Rickert¹, D. M. Detelich¹, T. Oura¹, W. Somer¹, I. Rosales², R. N. Pierson¹, J. Markmann¹, J. C. Madsen¹, T. Kawai¹
¹Surgery, MGH, Boston, MA, ²Pathology, MGH, Boston, MA
*Purpose: Genetically modified Galactose-α 1,3-galactose knockout transgenic swine expressing human CD55 (GTKO.hCD55) are resistant to hyperacute rejection of xenografts. We compare anti-CD154 and anti-CD40 antibody-based…
2019 American Transplant Congress
Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate
H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, I. Rosales², B. Cosimi¹, P. Cippa³, T. Fehr³, T. Kawai¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³Medicine, University of Zurich, Zurich, Switzerland
*Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
2019 American Transplant Congress
Hope in Action: A Multicenter Prospective Study of HIV to HIV Kidney Transplantation
C. Durand¹, S. Huprikar², M. Bowring³, D. Brown¹, B. Haydel⁴, N. Desai³, F. Naqvi¹, R. Friedman-Moraco⁵, N. Turgeon⁶, V. Stosor⁷, J. Charette⁷, S. Mehta⁸, J. Husson⁹, A. Gilbert¹⁰, M. Cooper¹¹, C. Butkus-Small¹², G. Gupta¹³, S. Mehta¹⁴, O. Adebiyi¹⁵, P. Chin-Hong¹⁶, P. Stock¹⁷, A. Massie³, S. Florman⁴, D. Segev³
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Medicine, Mount Sinai, New York, NY, ³Surgery, Johns Hopkins University, Baltimore, MD, ⁴Surgery, Mount Sinai, New York, NY, ⁵Medicine, Emory University, Atlanta, GA, ⁶Surgery, Emory University, Atlanta, GA, ⁷Medicine, Northwestern University, Chicago, IL, ⁸Medicine, University of Alabama, Birmingham, AL, ⁹Medicine, University of Maryland, Baltimore, MD, ¹⁰Medicine, Georgetown University, Washington DC, DC, ¹¹Department of Surgery, Georgetown University, Washington DC, DC, ¹²Medicine, Cornell University, New York, NY, ¹³Medicine, Virginia Commonwealth University, Richmond, VA, ¹⁴Medicine, New York University, New York, NY, ¹⁵Medicine, Indiana University, Indianapolis, IN, ¹⁶Medicine, University of California at San Francisco, San Francisco, CA, ¹⁷Surgery, University of California at San Francisco, San Francisco, CA
*Purpose:HIV+ donor to HIV+ recipient (HIV D+/R+) kidney transplantation (KT) has had success in South Africa. Expansion of this practice in the US setting of…