Am J Transplant, Volume 19, Suppl 3 Archives - Page 73 of 214 - ATC Abstracts

2019 American Transplant Congress
Renal Outcomes from Expander-1: Pilot Study of HCV+ Donor Kidneys for HCV- Kidney Recipients
S. Thaduri¹, C. Durand¹, N. Desai², D. Segev², N. Bair¹, D. Brown¹, F. F. Naqvi¹
¹Medicine, -Johns Hopkins University, -Baltimore, MD, ²Surgery, -Johns Hopkins University, -Baltimore, MD
*Purpose: Direct acting antivirals (DAAs) have led to high cure rates (>95%) for hepatitis C. Utilization of HCV+ donor kidneys for patients with advanced kidney…
2019 American Transplant Congress
Opioid Minimization in Kidney Transplant: Achievable Quicker Than You Think
J. N. Fleming, N. Patel, H. Gonzales, N. A. Pilch, S. Parks, C. Perez, P. K. Baliga, S. N. Nadig, D. J. Taber, V. Rohan
Medical University of South Carolina, Charleston, SC
*Purpose: Opioid use after kidney transplant has been shown to be a risk factor for chronic opioid use, which leads to an increased risk of…
2019 American Transplant Congress
Treg Suppressor Function within Allografts is Required for Tolerance
J. Ossart, A. Pena, H. Dai, L. Bauer, A. Williams, G. Camirand
Surgery, University of Pittsburgh, Pittsburgh, PA
*Purpose: The role of regulatory CD4+Foxp3+ T cells (Treg) suppressor function within allografts in tolerance remains unclear. Thus, we sought to directly address: 1) whether…
2019 American Transplant Congress
Analysis of Immune Cell Proportions in Kidney Transplant Biopsies of Acute Cellular Rejection and Antibody Mediated Rejection Compared with Non-Rejecters
C. R. Dorr¹, A. Muthusamy¹, D. P. Schladt¹, W. Guan², B. Wu², J. S. Maltzman³, W. S. Oetting², P. A. Jacobson², A. K. Israni¹
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Stanford University, Palo Alto, CA
*Purpose: Understanding the immune cell types that are associated with acute rejection (AR) in kidney transplant biopsies may lead to new therapeutic targets for AR.…
2019 American Transplant Congress
Replication of Diagnostic Biomarkers Using Orthogonal State-of-the-Art Technologies
M. Cassidy, B. Dooley, A. Verma, H. Yang, T. Muthukumar, R. Ding, C. Li, C. Snopkowski, B. Botticelli, S. Albakry, E. Edusei, M. Lubetzky, D. Dadhania, J. Lee, O. Elemento, M. Suthanthiran
WCM, New York, NY
*Purpose: The failure to reproduce scientific findings (McNutt M. Science 2014;343:229, Baker M. Nature 2016;53:452) has brought to the forefront the need for replication studies…
2019 American Transplant Congress
Treg Plasticity is Induced by ENV,HERV1_I and UPR Activation in De Novo Autoimmune Hepatitis
J. Yao¹, A. Ling¹, A. Arterbery¹, Y. Avitzur², S. Lobritto³, M. Martinez³, U. Ekong¹
¹Yale University, New Haven, CT, ²University of Toronto, Toronto, ON, Canada, ³Columbia University, New York, NY
*Purpose: FOXP3+regulatory T cells (Tregs) are not a terminally differentiated population & can, under specific environmental conditions, acquire the phenotype of effector T cells. We…
2019 American Transplant Congress
A Novel Multi-Thermic, Antiseptic, and Anthropomorphic System for Ex-Vivo Face Perfusion
J. W. Etra¹, J. Brassil², F. A. Chang¹, S. A. Fidder¹, D. S. Cooney¹, G. Brandacher¹
¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Functional Circulation LLC, Northbrook, IL
*Purpose: Facial disfigurement is profoundly disabling, and great relief follows resolution by facial transplantation, now a technical reality at multiple centers worldwide. However, distance between…
2019 American Transplant Congress
AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine DLA-Mismatch Model
B. Swearingen¹, S. Graves², R. Storb², D. W. Mathes¹
¹University of Colorado School of Medicine, Aurora, CO, ²Fred Hutchinson Cancer Research Center, Seattle, WA
*Purpose: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols rely on…
2019 American Transplant Congress
NQO-1 Attenuates Renal Ischemia-Reperfusion Injury in Mice
D. Choi¹, J. Hwang², J. Jeong³, K. Lee¹, K. Na¹, Y. Ham¹, J. Jeon¹, H. Kim¹, Y. Chang¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Republic of, ³Medical Science, Chungnam National University, Daejeon, Korea, Republic of
*Purpose: Ischemia-reperfusion (I-R)-induced reactive oxygen species (ROS) are thought to be a major factor in the development of acute renal injury by promoting the initial…
2019 American Transplant Congress
Kidney-Intrinsic Innate Immunity and Endoplasmic Reticulum Stress Pathways are Key Determinants of Severity of Ischemia-Reperfusion Injury Following Transplantation
L. Qiu¹, J. Wang¹, X. Yeap¹, C. Lin¹, Y. S. Kanwar², D. Fang², M. M. Abecassis¹, Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Ischemia-reperfusion injury (IRI) following kidney transplantation (KTx) frequently leads to delayed graft function and is detrimental to graft longevity. Causes and susceptibilities of KTx…