Am J Transplant, Volume 19, Suppl 3 Archives - Page 7 of 214 - ATC Abstracts

2019 American Transplant Congress
Experience With Letermovir Use For The Management Of Cytomegalovirus In Solid Organ Transplant Recipients
J. L. Orejas¹, F. M. Marty¹, A. M. McDonnell², M. P. Cheng¹, E. Arbona-Haddad¹, S. P. Hammond¹, S. Koo¹
¹Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, ²Department of Pharmacy, Brigham and Women's Hospital, Boston, MA
*Purpose: Letermovir is a new antiviral recently approved for cytomegalovirus (CMV) prophylaxis in CMV-seropositive hematopoietic-cell transplant recipients. Its off-label use in solid organ transplant (SOT)…
2019 American Transplant Congress
CCR5-Mediated Recruitment of NK Cells to the Kidney is a Critical Step for Host Defense to Candida albicans Infection
H. R. Cho¹, V. G. Tran², N. N. Nguyen³, S. Lee⁴, S. W. Kang⁴, J. Kim⁴, H. J. Kim⁴, S. J. Park¹, J. S. Lee⁵, B. Kwon⁶
¹Department of Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of, ²School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea, Ulsan, Korea, Republic of, ³1School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea, Ulsan, Korea, Republic of, ⁴Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, ⁵Division of Nephrology, Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of, ⁶Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Korea, Republic of
*Purpose: Candida albicans infection causes a high rate of mortality in immunocompromised or transplant patients. In this study, we investigated the role of CCR5 that…
2019 American Transplant Congress
Impact of a Short Duration, Narrow Spectrum Perioperative Antibiotic Prophylaxis Regimen on Multi-Drug Resistant Surgical Site Infections in Adult Orthotopic Liver Transplantation
M. John¹, K. Maguigan¹, D. Schain², E. Thomas³, P. Efron⁴, J. Nelson⁵
¹Pharmacy, UF Health Shands Hospital, Gainesville, FL, ²Infectious Diseases, UF Health Shands Hospital, Gainesville, FL, ³Transplant Surgery, University Health System, San Antonio, TX, ⁴Surgery, UF Health Shands Hospital, Gainesville, FL, ⁵Pharmacy, University Health System, San Antonio, TX
*Purpose: There is a paucity of data defining the optimal agent and timing of peri-operative antimicrobial prophylaxis in orthotopic liver transplantation (OLT). The purpose of…
2019 American Transplant Congress
Long Term Cold Ischemia Time in Kidney Transplantation. The Role of Hypothermic Machine Perfusion
G. ADANI¹, U. Baccarani¹, P. Tulissi², C. Vallone², A. Risaliti¹
¹General Surgery and Transplantation, Academic Hospital P. le S.M. della Misericordia, 33100 Udine, Italy, Udine, Italy, ²Nephrology, Dialysis and Kidney Transplantation, Academic Hospital P. le S.M. della Misericordia, 33100 Udine, Italy, Udine, Italy
*Purpose: Hypothermic machine perfusion (HMP) of deceased donor kidneys is associated with a better outcome than static cold storage (SCS). Aim of this prospective study…
2019 American Transplant Congress
Impact of an Intra-Abdominal Cooling Device during Open Kidney Transplantation in Pigs
A. Longchamp¹, R. P. Meier², N. Colucci³, A. Balaphas³, L. Orci³, A. Nastasi³, G. Longchamp¹, S. Moll⁴, A. Klauser⁵, F. Lazeyras⁵, M. Pascual⁶, J. Corpataux⁷, L. Bühler⁸
¹Department of Vascular Surgery, CHUV, Lausannne, Switzerland, ²Department of Surgery, University of California San Francisco, San Francisco, CA, ³Department of Surgery, HUG, Geneva, Switzerland, ⁴Department of Pathology, HUG, Geneva, Switzerland, ⁵Department of Radiology, HUG, Geneva, Switzerland, ⁶Department of Transplantation, CHUV, Lausannne, Switzerland, ⁷Department of Vascular Surgery, CHUV, Lausanne, Switzerland, ⁸Department of Surgery, CHUV, Lausannne, Switzerland
*Purpose: Renal transplantation is the preferred treatment for end-stage renal disease. Currently, there is a large gap between the supply and demand for transplantable kidneys.…
2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial Outcomes: Proteomic Analysis of Perfusates from Livers Undergoing Normothermic Machine Liver Perfusion Reveals Biomarkers Predictive of Graft Viability and Post-Transplant Complications
S. Afford¹, L. Wallace¹, J. Attard¹, Y. Boteon¹, R. Laing¹, J. Yu², T. Perera³, D. Mirza⁴, H. Mergental⁵
¹Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, ²The School of Biosciences Proteomics Facility, University of Birmingham, Birmingham, United Kingdom, ³Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom, ⁴Liver Unit, The Queen Elizabeth University Hospital, Birmingham, United Kingdom, ⁵The Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom
*Purpose: The VITTAL clinical trial demonstrated that post-ischaemic normothermic machine perfusion(NMP) can increase utilisation of livers from the marginal pool of extended criteria donors (ECD).…
2019 American Transplant Congress
ICOS⁺PD-1⁺ Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactivity and Predict Donor-Specific Antibody Generation Following Transplantation
G. M. La Muraglia II, M. E. Wagener, M. L. Ford, I. R. Badell
Emory Transplant Center, Atlanta, GA
*Purpose: Mounting evidence in kidney transplantation suggests that donor-specific antibodies (DSA) significantly contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA…
2019 American Transplant Congress
Donor-Recipient HLA Mismatched Peptides Calculated by PIRCHE Algorithm Associate with De Novo Donor-Specific Cellular and Humoral Alloreactivity and Predicts Inferior Graft Outcome
M. Meneghini¹, E. Crespo², M. Niemann³, A. Torija², E. Melilli⁴, M. Jarque², N. Montero⁴, J. Cruzado¹, J. Grinyo¹, O. Bestard¹
¹Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ²Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ³PIRCHE AG, Berlin, Germany, ⁴Kidney Transplantation Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain
*Purpose: PIRCHE-II algorithm predicts mismatched donor-derived HLA peptides number presented on recipient HLAclass-II molecules to recipient T-cells (indirect pathway of allorecognition) and has been associated…
2019 American Transplant Congress
Association between Recipient Sex and Risk of Heart Graft Failure
A. Chackowicz¹, X. Zhang², M. Dahhou², R. Sapir-Pichhadze³, H. Cardinal⁴, B. Foster⁵
¹Faculty of Medicine, McGill University, Montreal, QC, Canada, ²Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³Dept. of Medicine, McGill University, Montreal, QC, Canada, ⁴Dept. of Medicine, Université de Montréal, Montreal, QC, Canada, ⁵Dept. of Pediatrics, McGill University, Montreal, QC, Canada
*Purpose: Previous studies of sex differences in heart transplant outcomes focused on interactions between donor and recipient sex, but did not consider the potentially modifying…
2019 American Transplant Congress
Anemia and Hemolysis on Dapsone Despite Normal Glucose-6-Phosphate Dehydrogenase Activity in Heart Transplant Recipients
K. Lor, E. Kransdorf, J. Patel, M. Kittleson, D. Chang, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Dapsone has been considered an acceptable alternative for pneumocystis jirovecii pneumonia (PCP) prophylaxis in sulfa-allergic or -intolerant transplant patients with normal glucose-6-phosphate dehydrogenase (G6PD)…

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