Am J Transplant, Volume 19, Suppl 3 Archives - Page 61 of 214 - ATC Abstracts

2019 American Transplant Congress
The First Human Organ Transported by Drone and Steps Forward to Large Scale Organ Drone Use in the USA
J. R. Scalea¹, M. Scassero², N. Wereley³
¹Surgery, University of Maryland, Baltimore, MD, ²UAS Test Site, University of Maryland, California, MD, ³Aerospace Engineering, University of Maryland, College Park, MD
*Purpose: Organ transportation has yet to be substantially innovated. Cold ischemia times (CIT) for kidneys are too long, and prolongation of CIT leads to delayed…
2019 American Transplant Congress
Pediatric Liver Transplantation for Metabolic Disorders without Intrinsic Liver Disease: A 25 Year Experience
P. Vuong, L. Lee, N. Mineyev, S. Conlon, R. Shetty, W. Concepcion, C. A. Bonham, A. Gallo, T. Pham, S. Busque, M. L. Melcher, G. M. Enns, C. O. Esquivel
Stanford University Medical Center, Palo Alto, CA
*Purpose: Liver transplantation (LT) for acute and chronic end-stage-liver-disease is a well-accepted therapy in pediatrics. However, for children with metabolic disorders (MD) without intrinsic liver…
2019 American Transplant Congress
Single-center Retrospective Analysis of Prophylaxis and Treatment of Pneumocystis Carinii Pneumonia in Patients with Poor Renal Function
Y. Fu, J. Pan, Z. Shen
Kidney-Pancreas Transplant Department., Tianjin First Central Hospital, Tianjin, China
*Purpose: Pneumocystis carinii pneumonia (PcP) is a potentially life-threatening complication in renal transplant recipients. Although the use of trimethoprim-sulfamethoxazole (TMP-SMX) chemoprophylaxis after kidney transplantation is…
2019 American Transplant Congress
Responder B Cell Depletion Increased Allo-Reactive Regulatory T Cells Generated in Allo-Anergization
N. Tanimine¹, L. Contreras-Ruiz², K. Deng¹, N. Feeney¹, C. Rickert¹, K. Lee¹, E. Guinan³, J. Markmann¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, ³Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA
*Purpose: Regulatory T cells (Tregs) are promising tool for induction and maintenance of transplantation tolerance. We have done a feasibility trial in kidney transplant recipients…
2019 American Transplant Congress
The Effects of Chronic Kidney Disease on Antiviral T Cell Response
R. L. Crepeau¹, H. Li², L. P. Daley-Bauer³, M. L. Ford¹, P. D. Winterberg²
¹Emory Transplant Center, Atlanta, GA, ²Pediatrics, Emory University School of Medicine, Atlanta, GA, ³Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). Cytomegalovirus (CMV) establishes…
2019 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens (Cardiac Myosin and Vimentin) and De Novo Development of Antibodies to Cardiac Self-Antigens Precedes Chronic Cardiac Allograft Rejection
R. Ravichandran, Y. Itabashi, W. Liu, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the kinetics of induction of circulating exosomes with cardiac self-antigens (SAgs), cardiac myosin (MYO) and Vimentin…
2019 American Transplant Congress
FK506 Influence Glucose Metabolism by Short Chain Fatty Acid
W. Jiao¹, Z. Zhang¹, L. Liu², X. Hu¹
¹Urology, Capital Medical University Beijing Chaoyang Hospital, Beijing, China, ²GI Divison, West China Hospital, Beijing, China
*Purpose: FK506 is one of the most common immunosuppressant drugs in organ transplantation, which have been demonstrated to cause glucose metabolism disorder and alterd the…
2019 American Transplant Congress
Changes in Kidney Offer Acceptance for Pediatric Candidates Post-KAS
M. Bowring, K. Jackson, J. Garonzik-Wang, D. Segev, A. Massie
Johns Hopkins University, Baltimore, MD
*Purpose:Stakeholders have expressed concerns regarding kidney transplant rates for pediatric candidates under KAS. To better understand what might be driving potential declines in access, we…
2019 American Transplant Congress
Anti-HLA IgM Antibodies Are Reduced in Highly-HLA Sensitized Patients Transplanted after Imlifidase (IdeS) Treatment
X. Zhang¹, S. Jordan²
¹HLA and Immunogenetics Laboratory, Comprehensive Transplant Center, Cedars-Sinai Health System, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Health System, Los Angeles, CA
*Purpose: Immunoglobulin-degrading enzyme from Streptococcus pyogenes (IdeS, Imlifidase) has been used to reduce antibody levels to promote transplant of highly sensitized patients. In vitro experiments…
2019 American Transplant Congress
Molecular Analysis of Rejection and Injury in Human Liver Transplant Biopsies: First Results of the INTERLIVER Study
P. F. Halloran and The INTERLIVER Study Group
University of Alberta, Edmonton AB, AB, Canada
*Purpose: The relationship of histologic liver transplant biopsy assessments to actual rejection and injury is unclear. Recent progress in molecular reclassification of kidney, heart, and…