ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Subclinical Rejection by Biopsy or Gene Expression Profile Predicts Long Term Kidney Function in Patients in the CTOT08 Trial

    R. Heilman1, D. Taber2, K. Guo3, S. Brietigam3, j. charette3, S. Kurian4, M. Abecassis3, J. Friedewald3

    1Mayo Clinic AZ, Scottsdale, AZ, 2MUSC, Charleston, SC, 3Northwestern University, Chicago, IL, 4Scripps, La Jolla, CA

    *Purpose: The CTOT08 trial showed that either histological subAR or positive gene expression profile (GEP) in the blood associated with histological subAR correlated with a…
  • 2019 American Transplant Congress

    Predicting Allograft Outcomes of Renal Transplantation with Pretransplant Metrics

    J. Tchervenkov1, M. Nguyen2, S. Negi1, S. Paraskevas1

    1RIMUHC, Montreal, QC, Canada, 2SSM Health Saint Louis University Hospital, St. Louis, MO

    *Purpose: Early allograft dysfunction as well as long-term graft loss are major obstacles to successful kidney transplantation. Currently, kidney donor risk index (KDRI) is used…
  • 2019 American Transplant Congress

    Change in Estimated Glomerular Filtration Rate and Risk of Allograft Failure in Patients Diagnosed with Active Antibody-Mediated Rejection Following Kidney Transplantation

    W. Irish1, P. Nickerson2, B. Astor3, E. Chong4, C. Wiebe2, F. Moreso5, D. Seron5, M. Crespo5, L. Gache6, A. Djamali3

    1East Carolina University, Greenville, NC, 2University of Manitoba, Winnipeg, MB, Canada, 3University of Wisconsin, Madison, WI, 4Vitaeris, Inc, Vancouver, BC, Canada, 5University Hospital Vall d'Hebron, Barcelona, Spain, 6CTI Clinical Trial & Consulting, Covington, KY

    *Purpose: There are challenges in designing an adequate and well-controlled study of patients with active antibody-mediated rejection (ABMR), especially in the absence of a valid…
  • 2019 American Transplant Congress

    Donor And Recipient Age Matching Versus Mismatching In Expanded Criteria Donor Kidney Transplants: Does It Make A Difference?

    D. Harriman, V. Gurram, A. Farney, J. Rogers, G. Orlando, C. Jay, A. Reeves-Daniel, A. Mena-Gutierrez, M. Gautreaux, W. Doares, S. Kaczmorski, R. Stratta

    Wake Forest Baptist Medical Center, Winston-Salem, NC

    *Purpose: The critical shortage of donor organs challenges the transplant community to optimize the use of organs from all consented deceased donors (DD). The purpose…
  • 2019 American Transplant Congress

    Race-Sex Effects on Immune Response Potential during Tacrolimus Minimization Therapy in Stable Renal Allograft Recipients

    K. Tornatore1, K. Attwood2, R. Venuto3, H. Minderman4

    1University at Buffalo; School of Pharmacy, Buffalo, NY, 2Biostatistics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 3University at Buffalo; School of Medicine: Nephrology, Buffalo, NY, 4Flow & Image Cytometry, Roswell Park Comprehensive Cancer Center, Buffalo, NY

    *Purpose: African American renal transplant recipients (RTR) exhibit more immunoreactivity to allografts which may contribute to chronic rejection. This study investigated race-sex influences on ex…
  • 2019 American Transplant Congress

    Clinical Impact of Race and Timing of Acute Rejection on Recipients of Kidney Transplant on Early Steroid Withdrawal Protocol

    O. Adebiyi, S. Yaqub, W. Goggins, D. Mishler, T. Taber, A. Sharfuddin

    Indiana University, Indianapolis, IN

    *Purpose: There has been conflicting reports on the impacts of the timing of acute rejection (AR) (early vs late) on the overall outcome of a…
  • 2019 American Transplant Congress

    Adverse Effect Differences between Tacrolimus-IR and LCP-Tacrolimus

    J. Hagopian1, C. Carthon1, S. January1, A. Gharabagi2, R. Delos Santos3, T. Horwedel4

    1Barnes-Jewish Hospital, Saint Louis, MO, 2St. Louis College of Pharmacy, Saint Louis, MO, 3Washington Universidy, Saint Louis, MO, 4Veloxis Pharmaceuticals, Inc, Cary, NC

    *Purpose: Extended-release tacrolimus (Envarsus XR®, LCP-Tac) was approved in 2015 as conversion from tacrolimus immediate-release (Tac-IR) as part of the maintenance immunosuppression regiment post-kidney transplant.…
  • 2019 American Transplant Congress

    Early Renal Allograft Failure after Simultaneous Liver-Kidney Transplantation: Evidence for Utilization of the Safety Net

    G. Cullaro1, E. C. Verna2, B. J. Orandi3, J. C. Lai1

    1UCSF, San Francisco, CA, 2Columbia University, New York, NY, 3University of Alabama at Birmingham, Birmingham, AL

    *Purpose: Utilization of simultaneous liver-kidney transplant (SLKT) has increased dramatically during the Model for End-Stage Liver Disease (MELD) era. Prior studies have demonstrated a modest…
  • 2019 American Transplant Congress

    Incidence and Predictors of Post-Kidney Biopsy (KBx) Bleeding in Liver Transplant (LT) Candidates with Renal Dysfunction

    H. M. Wadei1, P. Abader1, N. Aslam2, T. Jarmi1, A. P. Keaveny1, K. Croome1, D. D. Lee1, C. Taner1

    1Department of Transplant, Mayo Clinic, Jacksonville, FL, 2Department of Medicine, Division of Nephrology, Mayo Clinic, Jacksonville, FL

    *Purpose: Pre-LT kidney biopsy is seldom performed in LT candidates with renal dysfunction and/or proteinuria partially due to the limited information regarding KBx bleeding. We…
  • 2019 American Transplant Congress

    Preoperative Risk Factor-based Cardiac Catheterization Is Associated With Low Cardiac Morbidity And Mortality In Liver Transplant Patients

    R. Rachwan1, I. Kutkut1, P. D. Bourdillon2, L. R. Timsina3, M. Ghabril4, C. A. Kubal5, M. A. Lacerda6, R. S. Mangus5

    1Internal Medicine, Indiana University, Indianapolis, IN, 2Internal Medicine, Indiana University, Division of Cardiology, Indianapolis, IN, 3Department of Biostatistics, Indiana University, Indianapolis, IN, 4Internal Medicine, Indiana University, Division of Hepatology, Indianapolis, IN, 5Surgery, Transplant Division, Indiana University, Indianapolis, IN, 6Internal Medicine, Division of Hepatology, Indiana University, Indianapolis, IN

    *Purpose: Mortality post-liver transplant historically was largely attributed to coronary artery disease (CAD). Current guidelines recommend screening with non-invasive modalities in patients with risk factors.…
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