ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Parental Anxiety and Depression Rates across Pediatric Solid Organ Transplant Populations

    A. M. Lofton1, A. Wille1, E. A. Steinberg2, C. Buchanan2

    1Psychiatry, Children's Hospital Colorado, Aurora, CO, 2Psychiatry, University of Colorado SOM, Children's Hospital Colorado, Aurora, CO

    *Purpose: This study’s purpose is to examine parental self-report of depression and anxiety symptoms during the pre-transplant evaluation process for solid organ transplant pediatric candidates…
  • 2019 American Transplant Congress

    Post-Transplant Cancer Following Living Donor HLA-Incompatible Kidney Transplantation

    J. D. Motter1, K. Jackson1, S. Bae1, X. Luo1, J. Long1, L. Kucirka1, B. Orandi2, A. Muzaale1, J. Coresh1, J. Garonzik-Wang1, D. Segev1, A. Massie1

    1Johns Hopkins University, Baltimore, MD, 2University of Alabama, Birmingham, AL

    *Purpose: Incompatible living donor kidney transplantation (ILDKT) recipients require increased immunosuppression compared to their compatible living donor kidney transplant (CLDKT) counterparts. This continued exposure to…
  • 2019 American Transplant Congress

    Retrospective Nested Case Control Study of the Impact of Immunosuppression on Post Transplant Malignancy among Adult Heart Transplant Patients

    S. Crow, R. J. Bubik, S. S. Kushwaha, K. C. Mara, R. A. Dierkhising, N. L. Pereira

    Mayo Clinic, Rochester, MN

    *Purpose: Post-transplant malignancy is diagnosed in approximately 18% of heart transplant (HTx) recipients and is a leading long-term cause of death among these patients. The…
  • 2019 American Transplant Congress

    Transplantation of Hepatitis C Virus Positive Donor Kidneys into Hepatitis C Negative Older Recipients

    J. A. Graham1, M. Ajaimy2, J. Torabi1, T. Powell3, J. Weiss4, T. Weinstein5, S. Greenstein1, O. Andacoglu1, A. Campbell6, J. Carrero1, J. Lapponese1, M. Kinkhabwala1, E. Akalin2, J. P. Rocca1

    1Surgery, Montefiore Medical Center, Bronx, NY, 2Medicine, Montefiore Medical Center, Bronx, NY, 3Epidemiology and Psychiatry, Montefiore Medical Center, Bronx, NY, 4Medical Affairs, Montefiore Medical Center, Bronx, NY, 5Risk & Loss Prevention, Montefiore Medical Center, Bronx, NY, 6Pharmacy, Montefiore Medical Center, Bronx, NY

    *Purpose: Patients awaiting transplantation are often at risk of developing life-threatening disease and complications. Older patients have a disproportionately higher risk of dropping out of…
  • 2019 American Transplant Congress

    Blood Profiling Reflects a Significant Down-Regulation in Oxidative Phosphorylation Following Renal Transplantation with DCD and AKI Allografts

    S. Walker1, L. Cox2, C. Langefeld2, B. Freedman2, A. Farney2, J. Rogers2, C. Jay2, R. Stratta2, G. Orlando2

    1Wake Forest Institute for Regenerative Medicine, Winston Salem, NC, 2Wake Forest Baptist Medical Center, Winston Salem, NC

    *Purpose: The human kidney transplant (KT) patient provides a unique and compelling in situ model system to study molecular events that underlie graft recovery following…
  • 2019 American Transplant Congress

    Perioperative Blood Transfusion Significantly Increases Inpatient Morbidity and Mortality in Renal Transplant Recipients: 15-year Experience

    K. Mahendraraj1, G. Medrano del Rosal1, M. Kruse1, R. Shah1, T. Katsichtis1, T. Brennan2, N. Nissen2, T. Todo2, K. Kosari2, A. Klein2, I. Kim2

    1Surgery, Lincoln Medical Center, New York, NY, 2Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: This study evaluates the immediate effects of perioperative blood transfusion (PBT) on inpatient morbidity and mortality among renal transplant (RT) recipients during their index…
  • 2019 American Transplant Congress

    Barriers to Pre-Transplant Immunization: A Qualitative Study of Pediatric Liver-Transplant Stakeholders

    A. G. Feldman1, R. Marsh2, A. Kempe3, M. Morris2

    1Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado, Aurora, CO, 2University of Colorado, Aurora, CO, 3Pediatrics, University of Colorado, Aurora, CO

    *Purpose: Less than 30% of pediatric liver transplant recipients are up-to-date on age-appropriate immunizations at the time of transplant despite being at high-risk for infections…
  • 2019 American Transplant Congress

    Ablation of Interferon Regulatory Factor 4 in T Cells Induces “Memory” of Transplant Tolerance That is Irreversible by Immune Checkpoint Blockade

    H. Zhang1, J. Wu2, D. Zou3, W. Chen3

    1The second Xiangya Hospital, Changsha, China, 2Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Immunobiology & Transplant Science Center, Houston Methodist Research Institute, Houston, TX

    *Purpose: Achieving alloantigen-specific transplant tolerance through ablation of interferon regulatory factor 4 in T cells*Methods: 1. Irf4fl/flCD4-Cre recipients were first transplanted with BALB/c hearts and…
  • 2019 American Transplant Congress

    Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice

    Y. Huang, H. Xu, Y. Wen, S. Ildstad

    University of Louisville, Louisville, KY

    *Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
  • 2019 American Transplant Congress

    Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy

    M. Ma, P. Chhabra, K. Brayman

    Surgery, University of Virginia, Charlottesville, VA

    *Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
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