2019 American Transplant Congress
Comparison of Two Glucagon-Like-Peptide-1 Analogs (GLP -1) Dulaglutide vs Liraglutide for the Management of Diabetes in Solid Organ Transplant (SOT)
Ohio State University, Columbus, OH
*Purpose: Poorly controlled Type-2 diabetes is an important contributor to graft dysfunction, and cardiovascular morbidity in the SOT. GLP-1-analog has been widely used in the…2019 American Transplant Congress
Variations in DCD Procurement Procedures across Opos and Their Effects on Liver Transplant Outcomes
*Purpose: Variations in procurement procedures across Organ Procurement Organizations (OPOs) may account for discrepancies in outcomes of donation after cardiac death (DCD) liver transplants. We…2019 American Transplant Congress
TORC1 Inhibition In Vitro and in a Humanized Mouse Model Protects Activated Human Regulatory T Cells from Self-Inflicted Damage via Granzyme B
Transplantation Research Center, BWH/Harvard Medical School, Boston, MA
*Purpose: Optimizing Regulatory T cells (Tregs) survival is of utmost importance to maximize the efficacy of utilizing them in adoptive cell therapy. We previously described…2019 American Transplant Congress
Antibody-Suppressor CD8+ T Cells Require CXCR5
*Purpose: We previously reported the novel activity of alloprimed CD8+ T cells that suppress post-transplant alloantibody production. The purpose of the current study was to…2019 American Transplant Congress
Opioid and Benzodiazepine Use in Lung Transplant Candidates: A National Survey of Policies and Practices
*Purpose: The opioid epidemic has raised the question of how transplant teams should work with patients who are prescribed opioids. Benzodiazepine use has also received…2019 American Transplant Congress
Butyrate-Producing Gut Bacteria and Future Development of Viral Infections in Kidney Transplant Recipients
1Weill Cornell Medicine, New York, NY, 2Memorial Sloan Kettering Cancer Center, New York, NY
*Purpose: Recent studies suggest that the gut microbiome plays a critical role in protecting its host from infections beyond Clostridium difficile. Notably, butyrate-producing bacteria may…2019 American Transplant Congress
Kidney Transplant Outcomes and Organ Acceptance Practice Patterns: Nationwide Analyses of the US and France
*Purpose: Approximately 3,500 donated kidneys are discarded in the US each year, drawing concern from Medicare and advocacy groups. We hypothesised that more aggressive organ…2019 American Transplant Congress
Infectious Complications of Eculizumab Use in Abdominal Organ Transplant Recipients
*Purpose: The purpose of this study is to identify and characterize infections in abdominal organ transplant recipients related to treatment with eculizumab. Eculizumab (Soliris®) is…2019 American Transplant Congress
Tertiary Lymphoid Organs in Renal Chronic Allograft Rejection
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Chronic allograft rejection remains a major obstacle to long-term allograft survival. Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues…2019 American Transplant Congress
CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…
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