Am J Transplant, Volume 19, Suppl 3 Archives - Page 55 of 214 - ATC Abstracts

2019 American Transplant Congress
Frailty and BMI in Liver Transplant Candidates: 9-Center Functional Assessment in Liver Transplantation Study
C. Haugen¹, M. McAdams-DeMarco¹, D. Segev¹, E. Verna², R. Rahimi³, M. Kappus⁴, M. Volk⁵, M. Dunn⁶, A. Duarte Rojo⁶, D. Granger⁷, J. O'Leary⁸, D. Ladner⁷, J. Lai⁹
¹JHU, Baltimore, MD, ²Columbia, NYC, NY, ³Baylor, Dallas, TX, ⁴Duke, Durham, NC, ⁵Loma Linda, Loma Linda, CA, ⁶Pitt, Pittsburgh, PA, ⁷Northwestern, Chicago, IL, ⁸DVA, Dallas, TX, ⁹UCSF, San Francisco, CA
*Purpose: Obesity and frailty are associated with an increased risk of waitlist mortality (WLM) in liver transplant (LT) candidates. However, body mass index (BMI) may…
2019 American Transplant Congress
Significantly High FOXP3 mRNA in the Renal Allograft as a Mechanism of Tolerance Induced by Transient Mixed Chimerism in Non-Human Primates
M. Matsunami¹, I. Rosales¹, T. Oura¹, B. Adam², M. Mengel², R. Smith¹, A. Cosimi¹, R. Colvin¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
*Purpose: Treg-rich organized lymphoid structures (TOLS) has been identified in recipients with renal allograft tolerance induced by transient mixed chimerism in non-human primates (NHPs) and…
2019 American Transplant Congress
Immunosuppression Increases Regenerative Potential of Adult Rat Cardiac Progenitor Cells in Allogeneic Rat Myocardial Infarction Model
M. Gunasekaran, R. Mishra, S. Sharma, P. Saha, M. Y. Arfat, C. Ambastha, D. Morales, F. Xuebin, G. J. Bittle, D. Li, S. Kaushal
Department of Surgery, University of Maryland, Baltimore 21201, MD
*Purpose: Cardiac progenitor cells (CPCs, c-kit+) are well-characterized stem cell type shown to potentiate cardiac regeneration in myocardial infarct (MI) model. However, immune response to…
2019 American Transplant Congress
Dialysis Facility Provider Transplant Knowledge after a Randomized Multilevel Intervention to Increase Kidney Transplant Referral and Evaluation in the Southeast
K. Maroney¹, R. Hamoda¹, L. McPherson¹, A. Cruz², S. Pastan¹, L. Plantinga¹, S. Paul¹, M. Ellis³, D. DuBay⁴, A. Reeves-Daniel⁵, R. Detwiler⁶, E. Hartmann⁷, H. Jones⁸, B. Thrasher⁹, C. Zayas¹⁰, L. Mulloy¹⁰, S. Wright¹¹, R. Patzer¹
¹Emory University, Atlanta, GA, ²IPRO Network of the South Atlantic, Raleigh, NC, ³Duke University, Durham, NC, ⁴Medical University of South Carolina, Charleston, SC, ⁵Wake Forest Health Transplant Center, Winston-Salem, NC, ⁶UNC Center for Transplantation, Chapel Hill, NC, ⁷Piedmont Transplant Institute, Atlanta, GA, ⁸Vidant Medical Center Transplant Services, Greenville, NC, ⁹Carolinas Transplant Center, Charlotte, NC, ¹⁰Augusta University, Augusta, GA, ¹¹IPRO Network of the South Atlantic, Morrisville, NC
*Purpose: Dialysis facility provider kidney transplantation (KTx) knowledge influences patient transplant access. The Reducing Disparities in Access to kidNey Transplantation (RaDIANT) Regional Study is a…
2019 American Transplant Congress
ABO Incompatibility in Kidney Transplantation Can Increase a Safety Margin of Epitope Mismatch Levels against De Novo DSA Production
T. Kobayashi¹, K. Iwasaki¹, M. Okada², K. Horimi¹, Y. Matsuoka¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan
*Purpose: Chronic antibody-mediated rejection (cABMR) caused by de novo donor specific HLA antibodies (DSA) is one of major obstacles to long term graft outcome. ABO…
2019 American Transplant Congress
Differential Impact of Donor and Recipient Age on Post-Lung Transplantation Outcomes
K. Patel¹, C. Li¹, C. Wallace¹, J. Kilkenny¹, D. P. Allen¹, S. Nadig¹, M. Goddard², C. Krieg¹, C. Atkinson¹
¹Surgery, Medical University of South Carolina, Charleston, SC, ²Pathology, Royal Papworth Hospital NHS Trust, C, SC
*Purpose: Donor and recipient age at the time of lung transplantation (LTx) have been implicated in poor patient outcomes. The underlying mechanisms driving these effects…
2019 American Transplant Congress
The Impact of Biological Behavior of Allograft Infiltrating Lymphocytes during Early Phase
Y. Ganchiku, R. Goto, R. Igarashi, R. Kanazawa, K. Shibuya, Y. Fukasaku, N. Kawamura, M. Zaistu, M. Watanabe, M. Fukai, A. Taketomi
Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan
*Purpose: The graft infiltrating lymphocytes (GILs) build an immunological microenvironment locally. Reportedly the GILs within 72hrs posttransplantation do not attack allograft, but may prevent from…
2019 American Transplant Congress
B Cell Immunophenotypes in Transplantation
M. Cascalho¹, M. de Mattos-Barbosa², E. A. Farkash³, J. L. Platt²
¹University of Michigan, Ann Arbor, MI, ²Surgery, University of Michigan, Ann Arbor, MI, ³Pathology, University of Michigan, Ann Arbor, MI
*Purpose: B cells and B cell responses have been associated with favorable outcomes of transplantation in some setting and unfavorable outcomes in others. For example,…
2019 American Transplant Congress
Beta₂-Adrenergic Receptor Activation Prolongs Survival of Vascularized Composite Tissue Allotransplants in a Murine Model
M. Kim¹, D. Fisher¹, J. Loo¹, P. Bogner², U. Sharma³, J. Skitzki¹, E. Repasky⁴
¹Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ²Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ³Cardiology, University at Buffalo, Buffalo, NY, ⁴Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
*Purpose: Transplantation of faces, hands, and limbs using vascularized composite allotransplantation (VCA) has faced significant challenges hindering its routine implementation in the clinic. One critical…
2019 American Transplant Congress
Protection of the Donor Kidney Vascular Endothelium by Ex-Vivo Perfusion with a Pan-Caspase Inhibitor
R. Plenter¹, S. Jain², T. Nydam¹, A. jani²
¹Transplant Microsurgery Program, University of Colorado, Aurora, CO, ²Renal Division, University of Colorado, Aurora, CO
*Purpose: Orthotopic kidney transplantation is a life-saving therapeutic option for patients with end stage organ failure. Pulsatile perfusion (PP) of deceased donor kidneys is increasingly…