Am J Transplant, Volume 19, Suppl 3 Archives - Page 38 of 214 - ATC Abstracts

2019 American Transplant Congress
Early CXCR5⁺PD1⁺ICOS⁺Circulating Follicular T Helpers Are Associated with De Novo Donor-Specific Anti-HLA Antibodies after Renal Transplantation
R. Danger¹, M. Chesneau¹, F. Delbos², S. Lebot¹, C. Kerleau¹, A. Chenouard¹, A. Cesbron², M. Giral³, S. Brouard³
¹CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France, ²Laboratoire Histocompatibilité et Immunogénétique - Etablissement Français du sang, Nantes, France, ³Centre d’Investigation Clinique en Biothérapie, Centre de ressources biologiques, Fondation Centaure, CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France
*Purpose: Donor specific anti-HLA antibodies (DSA) are a major risk factor associated with renal allograft outcome. As a trigger of B cell antibody production, T…
2019 American Transplant Congress
Total Parenteral Nutrition in Ex Vivo Lung Perfusion: Addressing Metabolism Improves Both Inflammation and Overall Graft Performance
M. T. Buchko, S. Hatami, C. J. Stewart, S. Himmat, D. H. Freed, J. Nagendran
Department of Surgery, Division of Cardiac Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Contemporary clinical ex vivo lung perfusion (EVLP) protocols generally limit metabolic supplementation to insulin and glucose. Furthermore, conventional perfusates are void of many ingredients…
2019 American Transplant Congress
Gender Disparity In Access To Liver Transplant Larger In White Than Black Patients
K. Guo, J. Peipert, M. Abecassis, L. Zhao, D. Ladner
Northwestern University, Chicago, IL
*Purpose: Disparities in receipt of liver transplantation (LT) by gender and race have been documented, limiting access to this life saving treatment for particular patient…
2019 American Transplant Congress
Long Term Renal Function Following Islet Transplantation in the Clinical Islet Transplantation Consortium
L. G. Hunsicker¹, T. L. Eggerman², M. R. Rickels³, t. Clinical Islet Transplantation (CIT) Consortium⁴
¹Internal Medicine, U. Iowa, Iowa City, IA, ²NIDDK/NIH, Bethesda, MD, ³Internal Medicine, U. Pennsylvania, Philadelphia, PA, ⁴Internal Medicine, University of Iowa, Iowa City, IA
*Purpose: Islet transplantation (IsletTp) is safe and effective treatment of Type 1 diabetes complicated by severe hypoglycemia (Diabetes Care 2016, 39:1230). But the requirement for…
2019 American Transplant Congress
A Novel Ex Vivo Normothermic Perfusion Model of Human Antibody Mediated Rejection
P. Chandak¹, B. L. Phillips¹, R. Uwechue¹, C. J. Callaghan¹, O. Shaw², T. Maggs³, L. Woodford³, D. Veniard³, R. Perera⁴, K. Parmar³, B. Hunt⁵, D. Bennett⁶, N. Kessaris¹, A. Dorling⁷, N. Mamode¹
¹Transplantation, Guy's and St Thomas Hospitals NHS Trust and King's College London, London, United Kingdom, ²Transplantation and CTL Laboratory, Guy's and St Thomas Hospitals NHS Trust and King's College London, London, United Kingdom, ³Haematology and Thrombosis, Guy's and St Thomas Hospitals NHS Trust, London, United Kingdom, ⁴Histopathology, Guy's and St Thomas Hospitals NHS Trust, London, United Kingdom, ⁵Haematology and Thrombosis, Guy's and St Thomas Hospitals NHS Trust and King's College London, London, United Kingdom, ⁶Interface Physics, University of Bristol, London, United Kingdom, ⁷Inflammation, Thrombosis and Repair and Transplantation, Guy's and St Thomas Hospitals NHS Trust and King's College London, London, United Kingdom
*Purpose: Currently, no human experimental model of antibody-mediated rejection (AMR) exists, making the assessment of therapeutic interventions difficult hence the aim of our work is…
2019 American Transplant Congress
Natural Anti-a Antibody Production In Mice Is Cd4 T Cell-independent
I. Adam¹, B. Motyka², L. West³
¹Medical Microbiology & Immunology, University of Alberta, Edmonton, AB, Canada, ²Pediatrics, University of Alberta, Edmonton, AB, Canada, ³Pediatrics, Surgery, Immunology, Lab Medicine & Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada
*Purpose: ABO-incompatible organ transplants (ABOi-Tx) are at high risk of rapid rejection mediated by preformed ABO antibodies (Ab) except during infancy when they are absent.…
2019 American Transplant Congress
TACI Polymorphisms Associated with Increased Alloimmunity and Allograft Rejection
M. Garcia de Mattos-Barbosa¹, E. A. Farkash², J. L. Platt¹, M. Cascalho¹
¹Transplant Surgery, University of Michigan, Ann Arbor, MI, ²Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Transmembrane activator and CAML interactor (TACI) controls B cell differentiation. The TACI gene is highly polymorphic (>95% of all genes) and frequently variants exhibit…
2019 American Transplant Congress
Desensitization Using Costimulatory Blockade and Bortezomib Does Not Prevent DSA Formation and Rejection in Reconstructive Transplantation
F. Messner¹, Y. Guo¹, R. Chen², Y. Kuo², G. Brandacher¹, B. Oh¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins UJohns Hopkins University School of Medicine, Baltimore, MD, ²Division of Plastic Surgery, Kaohsiung Medical Univerity Hospital, Kaohsiung, Taiwan
*Purpose: Sensitiziation in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection (AMR) constitute some of the greatest risk factors for allograft rejection and long-term…
2019 American Transplant Congress
Endothelial Cell Cytoskeleton Rearrangement (ECCSKR) and Endothelial to Mesenchymal Transition (EndoMT) in Liver Allografts Following Acute Rejection (AR): Its Significance on the Development of Liver Fibrosis (LF) and Graft Survival
B. H. Ozdemir¹, G. Ozgun¹, E. H. Ayvazoglu Soy², N. Haberal¹, G. Moray², M. Haberal²
¹Pathology, Baskent University, Ankara, Turkey, ²Transplantation, Baskent University, Ankara, Turkey
*Purpose: Endothelial cell (EC) cytoskeleton is critical for EC adhesion and permeability. CSKR initiates permeability and influx of leukocytes which in turn leads to increased…
2019 American Transplant Congress
Hypothermic Protection Attenuates Kidney Injury in Renal Ischemia-Reperfusion Injury via Phosphorylation of ERK
D. Choi¹, J. Jeong², K. Lee¹, K. Na¹, Y. Chang³, Y. Ham¹, J. Jeon¹, H. Kim¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Hypothermia attenuates the renal injury induced by ischemia-reperfusion. However, the detailed molecular pathway remains unknown. ERK and HIF1 are known to protect against ischemia-reperfusion…