Am J Transplant, Volume 19, Suppl 3 Archives - Page 35 of 214 - ATC Abstracts

2019 American Transplant Congress
Actual Outcomes and Technical Feasibility of Living Donor-Related Liver Re-Transplantation
W. Kim¹, G. Song², S. Lee²
¹Korea University Guro Hospital, Seoul, Korea, Republic of, ²Asan Medical Center, Seoul, Korea, Republic of
*Purpose: The aim of this study was to analyze the experience of liver re-transplantation (re-LT) at a large volume living donor liver transplantation (LDLT) center…
2019 American Transplant Congress
Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney
S. Noel¹, J. T. Kurzhagen¹, S. Lee¹, M. Sadasivam², A. R. Hamad², P. M. Pierorazio³, H. Rabb¹
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Pathology, Johns Hopkins University, Baltimore, MD, ³Urology, Johns Hopkins University, Baltimore, MD
*Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
2019 American Transplant Congress
IL-21 Induces the Transformation of Th Cell Subsets in Acute Rejection after Kidney Transplantation
H. Deng, R. Wang, J. Shen, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: IL-21 exhibits a wide range of immunomodulatory functions in the organism, regulating immune cells such as B cells and T cells. In this study,…
2019 American Transplant Congress
Allograft Survival is Influenced by Gut Microbiota-Dependent Modulation of Innate Immunity
V. Saxena¹, Y. Xiong¹, L. Hittle¹, L. Li¹, T. Simon², W. Piao¹, C. C. Brinkman¹, E. M. Smyth¹, T. Zhang¹, C. Wagner¹, C. M. Palusckievicz¹, W. F. Fricke³, E. F. Mongodin¹, J. S. Bromberg¹
¹U Maryland, Baltimore, MD, ²Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, CNRS, Valbonne, France, ³Institute of Biological Chemistry and Nutrition, U Hohenheim, Stuttgart, Germany
*Purpose: The gut microbiota driven inflammatory response and the host immune system engage bidirectional regulation of each other. These interactions are poorly characterized in organ…
2019 American Transplant Congress
Inhibition of Sialidase Activity and Galectin Binding Reduces Xenogeneic Neutrophil-Endothelial Adhesion
B. M. Cerel¹, B. M. French², D. G. Harris², C. Laird², L. Burdorf¹, X. Cheng², C. Feng³, A. S. Cross⁴, S. E. Goldblum⁴, G. R. Vasta³, R. N. Pierson III¹, A. M. Azimzadeh¹
¹Deparment of Surgery, Massachusetts General Hospital, Boston, MA, ²Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, ³Department of Microbiology and Immunology, and Institute of Marine and Environmental Technology, University of Maryland School of Medicine, Baltimore, MD, ⁴Department of Medicine Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD
*Purpose: Immediate neutrophil sequestration occurs despite genetic modifications (Gal-a-1-3 galactosyl transferase knock out; human CD46 complement regulatory gene addition) to pig donor organs. Sialic acids…
2019 American Transplant Congress
Blockade of C3aR1 Signaling Suppresses Alloreactive CD8⁺ T Cell Immunity and Prolongs Murine Cardiac Allograft Survival
J. Horwitz, D. Mathern, P. Heeger
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: Activation, differentiation and expansion of alloreactive CD8+ T cells, the dominant effectors that mediate murine heart allograft rejection, requires allorecognition, costimulation, and cytokine-initiated signals.…
2019 American Transplant Congress
National Landscape of Hope Act Transplant Candidates and Recipients in the United States
A. R. Wilk¹, R. Hunter², M. A. McBride², D. K. Klassen²
¹Research, United Network for Organ Sharing, Richmond, VA, ²United Network for Organ Sharing, Richmond, VA
*Purpose: The HIV Organ Policy Equity (HOPE) Act, enacted on 11/21/13, allows for the transplantation of organs from HIV+ donors into HIV+ recipients in the…
2019 American Transplant Congress
Long-Term Outcomes of Eculizumab-Treated Positive Crossmatch Recipients: Allograft Survival, Histologic Findings, and Natural History of the Donor-Specific Antibodies
C. Schinstock, A. Bentall, S. Byron, L. Cornell, M. Everly, M. Gandhi, M. Stegall
Mayo Clinic, Rochester, MN
*Purpose: We aimed to determine long-term outcomes for eculizumab-treated, positive crossmatch (+XM) kidney transplant recipients as compared with +XM and age-matched negative crossmatch (−XM) control…
2019 American Transplant Congress
Impact Of Delayed Kidney Transplantation On Positive Crossmatch Liver Kidney Transplantation
Z. Rokop, C. Kubal, B. Ekser, R. Mangus, J. Fridell, P. Mihaylov, W. Goggins
Department of Surgery, Indiana University Hospital, Indianapolis, IN
*Purpose: Kidney transplantation in sensitized patients is associated with an increased immunological risk. Significant decrease in circulating anti-HLA donor specific antibodies (DSA) has been observed…
2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes
J. Attard¹, W. Dunn², L. Wallace¹, R. Laing¹, Y. Boteon¹, H. Mergental³, D. Mirza³, T. Perera³, S. Afford¹
¹CLGR, University of Birmingham and NIHR Biomedical Research Centre, Birmingham, United Kingdom, ²Phenome Centre Birmingham, University of Birmingham, Birmingham, United Kingdom, ³Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom
*Purpose: Donor organ shortage has led to increased reliance on high-risk livers for transplantation. Furthermore, emergence of machine perfusion has led to a paradigm shift…