Am J Transplant, Volume 19, Suppl 3 Archives - Page 35 of 214 - ATC Abstracts

2019 American Transplant Congress
Staged Procedure In Simultaneous Liver And Kidney Transplant -the “Swedish” Experience
A. Gravetz
Transplant Surgery, Swedish Medical Center, Seattle, WA
*Purpose: As many as 30% of liver transplant candidates have renal insufficiency requiring a combined liver and kidney transplantation. The prolonged and complex simultaneous liver-kidney…
2019 American Transplant Congress
Statin Underutilization in Patients Listed for Liver Transplant
K. Mishra¹, S. Naffouj¹, S. Modi¹, C. Dagher¹, S. Gorgis¹, D. Venkat²
¹Internal Medicine, Henry Ford Hospital, Detroit, MI, ²Transplant Hepatology, Henry Ford Hospital, Detroit, MI
*Purpose: Current guidelines recommend statin use in high risk patients based on the ASCVD (atherosclerotic cardiovascular disease) score, diabetes, or LDL levels. Despite several trials…
2019 American Transplant Congress
Letermovir for CMV Treatment in Solid Organ Transplant
O. Witkowsky, M. Chunduru, A. Chung, A. Diez
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Letermovir (LET), a novel anti-CMV agent, was recently approved for CMV prophylaxis in stem cell transplant recipients and is currently under investigation as a…
2019 American Transplant Congress
Target Itraconazole Trough Concentration for Prophylaxis in Lung Transplant
J. A. Morillas-Rodriguez¹, H. Hassouna², F. Marco-Canosa³, K. D. Brizendine¹
¹Infectious disease, Cleveland Clinic, Cleveland, OH, ²Infectious disease, Spectrum health, Grand rapids, MI, ³Cleveland Clinic, Cleveland, OH
*Purpose: Itraconazole (ITR) therapeutic drug monitoring (TDM) for prophylaxis in lung transplant recipients (LTR) is not well characterized. Our purpose was to evaluate ITR trough…
2019 American Transplant Congress
A Nurse-Driven Influenza Vaccine Ordering Protocol Improves Vaccination Rates in Abdominal Organ Transplant Recipients
T. Ho¹, C. D. Sifri², J. D. Lewis³
¹Department of Medicine, Virginia Commonwealth University, Richmond, VA, ²Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, ³Division of Infectious Diseases, Medical University of South Carolina, Charleston, SC
*Purpose: Solid organ transplant (SOT) recipients are at increased risk of influenza infection and severe influenza-related complications. The influenza vaccine is a safe and effective…
2019 American Transplant Congress
Combined Ischemic and Rapamycin Preconditioning Alleviated Liver Ischemia and Reperfusion Injury by Restoring Autophagy in Old Mice
Z. Rao, X. Pan, W. Zhong, Z. Ding, H. Zhou, C. Liu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Old livers are more damaged by hepatic ischemia and reperfusion (IR) injury than young livers. The aim of this study was to investigate the…
2019 American Transplant Congress
Pgc1α Protects against Graft Ischemic Injury and Reduces Alloimmunity
T. J. Borges¹, M. T. Tran², S. Cai¹, N. Murakami¹, A. Uffing¹, M. Uehara¹, E. P. Rhee³, S. M. Parikh⁴, L. V. Riella¹
¹Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Nephrology Division, Massachusetts General Hospital, Boston, MA, ⁴Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
*Purpose: Prolonged ischemia reperfusion injury (IRI) during organ transplantation activates innate immunity and potentiates adaptive immunity, leading to worse transplant outcomes. The mitochondria are particularly…
2019 American Transplant Congress
Donor Management in Donation after Brain Death: A Window of Opportunity – Are Pro-Inflammatory Mediators the Target and What is the Effect of Duration of Brain Death?
K. D. Bera¹, J. Tabak², M. L. Lo Faro¹, R. J. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University of Exeter, Exeter, United Kingdom
*Purpose: Donation after brain death (BD) is a crucial source of transplanted organs - uncertainty remains how duration of BD contributes to outcomes: This study…
2019 American Transplant Congress
The Number of Donor-Specific IL-21 Producing Cells before and after Transplantation Predicts Kidney Graft Rejection
N. M. van Besouw¹, L. Yan¹, R. de Kuiper¹, M. Klepper¹, D. Reijerkerk¹, M. Dieterich¹, D. L. Roelen², F. H. Claas², M. C. Clahsen-van Groningen³, D. A. Hesselink¹, C. C. Baan¹
¹Internal Medicine - Nephrology & Transplantation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, ²Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, Netherlands, ³Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
*Purpose: Interleukin (IL)-21 supports induction and expansion of CD8+ T cells, and can also regulate the differentiation of B cells into antibody-producing plasma cells. We…
2019 American Transplant Congress
High Prevalence of Allergic Disorders but No Specific Immune Phenotype Pattern in Children Awaiting Transplantation
T. B. Kim¹, Y. Avitzur², L. Ionescu¹, U. Allen², S. Mital², B. Foster³, T. Blydt-Hansen⁴, L. Hamiwka⁵, P. Birk⁶, V. Phan⁷, S. Urschel¹
¹University of Alberta, Edmonton, AB, Canada, ²Hospital for Sick Children, Toronto, ON, Canada, ³McGill University, Montreal, QC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵University of Calgary, Calgary, AB, Canada, ⁶University of Manitoba, Winnipeg, MB, Canada, ⁷Université de Montréal, Montreal, QC, Canada
*Purpose: Allergic disorders (AD) occur more frequently in children after transplantation (Tx) compared to healthy children, reflecting an imbalance of the immune system in the…