ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Analysis and Regulation of Immune Reaction in the Transplantation from MHC Homozygous Donors to Heterozygous Recipients with Minor Antigen Mismatches

    T. Murata, H. Wada, R. Otsuka, H. Tsuji, A. Sasaki, M. Baghdadi, K. Seino

    Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan

    *Purpose: Induced pluripotent stem cells (iPSCs) is expected to be the source of therapeutic cells in the regenerative medicine. Autologous derivation of iPSCs is the…
  • 2019 American Transplant Congress

    Bcl-2/Bcl-xL Inhibition by Navitoclax vs. Bcl-2 Alone Inhibition by Venetoclax for Induction of Mixed Chimerism in Non-Human Primates

    H. Sasaki1, D. Ma1, T. Oura1, A. Dehnadi1, I. Rosales2, B. Cosimi1, P. Cippa3, T. Fehr3, T. Kawai1

    1Surgery, Massachusetts General Hospital, Boston, MA, 2Pathology, Massachusetts General Hospital, Boston, MA, 3Medicine, University of Zurich, Zurich, Switzerland

    *Purpose: We recently demonstrated that a specific Bcl-2 inhibitor, Venetoclax, can promote mixed chimerism and renal allograft tolerance in non-human primates (NHPs) with reduced myelosuppressive…
  • 2019 American Transplant Congress

    Graft-Infiltrating Regulatory T Cells Are Associated with Long Term Cardiac Xenograft Survival

    A. K. Singh1, G. Braileanu1, A. Hersfield1, L. DiChiacchio1, T. Zhang1, I. Tatarov1, D. Parsell1, B. Lewis1, F. Sentz1, D. Ayares2, M. Mohiuddin1

    1Department of Surgery, School of Medicine, University of Maryland Baltimore, Baltimore, MD, 2Revivicor, Inc, Blacksburg, VA

    *Purpose: Regulatory T (CD4+CD25HiFoxP3+) cells (Treg) are a very small subset of CD4+ T cells that have been shown to play an important role in…
  • 2019 American Transplant Congress

    Oxygenated Hypothermic Machine Perfusion of Kidneys Donated after Circulatory Death: An International Randomised Controlled Trial

    I. Jochmans1, H. S. Hofker2, L. Davies3, S. Knight3, J. Pirenne1, R. J. Ploeg3, -. on behalf of COPE and participating centres4

    1Abdominal Transplant Surgery, University Hospitals Leuven, Leuven, Belgium, 2University Medical Center Groningen, Groningen, Netherlands, 3University of Oxford, Oxford, United Kingdom, 4Belgium, Netherlands, United Kingdom

    *Purpose: An international, double-blinded, randomised, paired phase 3 trial designed to determine the effect on 1-year graft function of continuous oxygenated (HMPO) vs non-oxygenated hypothermic…
  • 2019 American Transplant Congress

    Accelerating Kidney Allocation: Simultaneously Expiring Offers

    M. Kosztowski1, M. Mankowski2, S. Raghavan3, J. Garonzik-Wang1, D. Axelrod4, D. L. Segev1, S. E. Gentry1

    1Johns Hopkins University, Baltimore, MD, 2King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, 3University of Maryland, College Park, MD, 4University of Iowa, Iowa City, IA

    *Purpose: Placing kidneys quickly might reduce discard. Additionally, a faster allocation system that reduces cold ischemia time would yield benefits: decreased delayed graft function, shorter…
  • 2019 American Transplant Congress

    Single Cell Sequencing of Human Kidney Allograft

    H. Yang1, H. Suryawanshi2, M. Lagman1, M. Lubetzky1, A. Alonso1, S. Seshan1, T. Tuschl2, M. Suthanthiran1, T. Muthukumar1

    1Weill Cornell Medicine, New York, NY, 2Rockefeller University, New York, NY

    *Purpose: Transcriptome-based clustering of individual cells within the kidney allograft may help identify cell type-specific injury and has the potential to redefine the current histopathology-based…
  • 2019 American Transplant Congress

    Regulation of Host microRNA Expression by Natural Variants of Epstein Barr Virus (EBV) Latent Membrane Protein 1 (LMP1)

    O. Hatton1, A. Harris-Arnold2, A. Hui2, E. Maloney2, S. M. Krams2, O. M. Martinez2

    1Molecular Biology, Colorado College, Colorado Springs, CO, 2Program in Immunology and Department of Surgery, Stanford University, Stanford, CA

    *Purpose: Malignancies attributable to EBV, such as post-transplant lymphoproliferative disorder (PTLD), represent 1.8% of global cancer deaths. PTLD occurs in 1-20% of transplant recipients and…
  • 2019 American Transplant Congress

    Development and Characterization of Human-Derived Xenograft Model for Hepatocellular Carcinoma

    M. Nazzal1, R. Steele2, R. Ray3, N. Phillips2, J. Long4, R. Ray2

    1Surgery, Saint Louis University, Saint Louis, MO, 2Pathology, Saint Louis University, Saint Louis, MO, 3Internal Medicine, Saint Louis University, Saint Louis, MO, 4Comparative Medicine, Saint Louis University, Saint Louis, MO

    *Purpose: Hepatocellular carcinoma (HCC) is rising in the USA and treatment options are limited. There is no convenient animal model for HCC to study novel…
  • 2019 American Transplant Congress

    Impact of Immunosuppressive Drug Withdrawal on Persistent Mixed Chimerism in Recipients of HLA Haplo-Identical Kidney and Hematopoietic Cell Transplants

    S. Busque, J. Scandling, R. Lowsky, J. Shizuru, E. Meyer, K. Jensen, A. Shori, R. Hoppe, E. Engleman, S. Strober

    Stanford University School of Medicine, Stanford, CA

    *Purpose: We assessed the impact of the hematopoietic cell dose and the immunosuppressive drug (IS) withdrawal on the persistence of mixed chimerism after combined HLA…
  • 2019 American Transplant Congress

    Normothermic Regional Perfusion of Kidneys: A Single Non-Retrieval Centre Experience

    R. Pearson, C. Geddes, M. Clancy, J. Asher

    Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom

    *Purpose: With the aim of safely expanding the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional (NRP) perfusion…
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