ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Incidence and Predictors of Post-Kidney Biopsy (KBx) Bleeding in Liver Transplant (LT) Candidates with Renal Dysfunction

    H. M. Wadei1, P. Abader1, N. Aslam2, T. Jarmi1, A. P. Keaveny1, K. Croome1, D. D. Lee1, C. Taner1

    1Department of Transplant, Mayo Clinic, Jacksonville, FL, 2Department of Medicine, Division of Nephrology, Mayo Clinic, Jacksonville, FL

    *Purpose: Pre-LT kidney biopsy is seldom performed in LT candidates with renal dysfunction and/or proteinuria partially due to the limited information regarding KBx bleeding. We…
  • 2019 American Transplant Congress

    Preoperative Risk Factor-based Cardiac Catheterization Is Associated With Low Cardiac Morbidity And Mortality In Liver Transplant Patients

    R. Rachwan1, I. Kutkut1, P. D. Bourdillon2, L. R. Timsina3, M. Ghabril4, C. A. Kubal5, M. A. Lacerda6, R. S. Mangus5

    1Internal Medicine, Indiana University, Indianapolis, IN, 2Internal Medicine, Indiana University, Division of Cardiology, Indianapolis, IN, 3Department of Biostatistics, Indiana University, Indianapolis, IN, 4Internal Medicine, Indiana University, Division of Hepatology, Indianapolis, IN, 5Surgery, Transplant Division, Indiana University, Indianapolis, IN, 6Internal Medicine, Division of Hepatology, Indiana University, Indianapolis, IN

    *Purpose: Mortality post-liver transplant historically was largely attributed to coronary artery disease (CAD). Current guidelines recommend screening with non-invasive modalities in patients with risk factors.…
  • 2019 American Transplant Congress

    Experience With Letermovir Use For The Management Of Cytomegalovirus In Solid Organ Transplant Recipients

    J. L. Orejas1, F. M. Marty1, A. M. McDonnell2, M. P. Cheng1, E. Arbona-Haddad1, S. P. Hammond1, S. Koo1

    1Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, 2Department of Pharmacy, Brigham and Women's Hospital, Boston, MA

    *Purpose: Letermovir is a new antiviral recently approved for cytomegalovirus (CMV) prophylaxis in CMV-seropositive hematopoietic-cell transplant recipients. Its off-label use in solid organ transplant (SOT)…
  • 2019 American Transplant Congress

    CCR5-Mediated Recruitment of NK Cells to the Kidney is a Critical Step for Host Defense to Candida albicans Infection

    H. R. Cho1, V. G. Tran2, N. N. Nguyen3, S. Lee4, S. W. Kang4, J. Kim4, H. J. Kim4, S. J. Park1, J. S. Lee5, B. Kwon6

    1Department of Surgery, Ulsan University Hospital, Ulsan, Korea, Republic of, 2School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea, Ulsan, Korea, Republic of, 31School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea, Ulsan, Korea, Republic of, 4Biomedical Research Center, Ulsan University Hospital, Ulsan, Korea, Republic of, 5Division of Nephrology, Department of Internal Medicine, Ulsan University Hospital, Ulsan, Korea, Republic of, 6Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan, Korea, Republic of

    *Purpose: Candida albicans infection causes a high rate of mortality in immunocompromised or transplant patients. In this study, we investigated the role of CCR5 that…
  • 2019 American Transplant Congress

    Impact of a Short Duration, Narrow Spectrum Perioperative Antibiotic Prophylaxis Regimen on Multi-Drug Resistant Surgical Site Infections in Adult Orthotopic Liver Transplantation

    M. John1, K. Maguigan1, D. Schain2, E. Thomas3, P. Efron4, J. Nelson5

    1Pharmacy, UF Health Shands Hospital, Gainesville, FL, 2Infectious Diseases, UF Health Shands Hospital, Gainesville, FL, 3Transplant Surgery, University Health System, San Antonio, TX, 4Surgery, UF Health Shands Hospital, Gainesville, FL, 5Pharmacy, University Health System, San Antonio, TX

    *Purpose: There is a paucity of data defining the optimal agent and timing of peri-operative antimicrobial prophylaxis in orthotopic liver transplantation (OLT). The purpose of…
  • 2019 American Transplant Congress

    Long Term Cold Ischemia Time in Kidney Transplantation. The Role of Hypothermic Machine Perfusion

    G. ADANI1, U. Baccarani1, P. Tulissi2, C. Vallone2, A. Risaliti1

    1General Surgery and Transplantation, Academic Hospital P. le S.M. della Misericordia, 33100 Udine, Italy, Udine, Italy, 2Nephrology, Dialysis and Kidney Transplantation, Academic Hospital P. le S.M. della Misericordia, 33100 Udine, Italy, Udine, Italy

    *Purpose: Hypothermic machine perfusion (HMP) of deceased donor kidneys is associated with a better outcome than static cold storage (SCS). Aim of this prospective study…
  • 2019 American Transplant Congress

    Impact of an Intra-Abdominal Cooling Device during Open Kidney Transplantation in Pigs

    A. Longchamp1, R. P. Meier2, N. Colucci3, A. Balaphas3, L. Orci3, A. Nastasi3, G. Longchamp1, S. Moll4, A. Klauser5, F. Lazeyras5, M. Pascual6, J. Corpataux7, L. Bühler8

    1Department of Vascular Surgery, CHUV, Lausannne, Switzerland, 2Department of Surgery, University of California San Francisco, San Francisco, CA, 3Department of Surgery, HUG, Geneva, Switzerland, 4Department of Pathology, HUG, Geneva, Switzerland, 5Department of Radiology, HUG, Geneva, Switzerland, 6Department of Transplantation, CHUV, Lausannne, Switzerland, 7Department of Vascular Surgery, CHUV, Lausanne, Switzerland, 8Department of Surgery, CHUV, Lausannne, Switzerland

    *Purpose: Renal transplantation is the preferred treatment for end-stage renal disease. Currently, there is a large gap between the supply and demand for transplantable kidneys.…
  • 2019 American Transplant Congress

    Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial Outcomes: Proteomic Analysis of Perfusates from Livers Undergoing Normothermic Machine Liver Perfusion Reveals Biomarkers Predictive of Graft Viability and Post-Transplant Complications

    S. Afford1, L. Wallace1, J. Attard1, Y. Boteon1, R. Laing1, J. Yu2, T. Perera3, D. Mirza4, H. Mergental5

    1Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, 2The School of Biosciences Proteomics Facility, University of Birmingham, Birmingham, United Kingdom, 3Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom, 4Liver Unit, The Queen Elizabeth University Hospital, Birmingham, United Kingdom, 5The Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom

    *Purpose: The VITTAL clinical trial demonstrated that post-ischaemic normothermic machine perfusion(NMP) can increase utilisation of livers from the marginal pool of extended criteria donors (ECD).…
  • 2019 American Transplant Congress

    ICOS+PD-1+ Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactivity and Predict Donor-Specific Antibody Generation Following Transplantation

    G. M. La Muraglia II, M. E. Wagener, M. L. Ford, I. R. Badell

    Emory Transplant Center, Atlanta, GA

    *Purpose: Mounting evidence in kidney transplantation suggests that donor-specific antibodies (DSA) significantly contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA…
  • 2019 American Transplant Congress

    Donor-Recipient HLA Mismatched Peptides Calculated by PIRCHE Algorithm Associate with De Novo Donor-Specific Cellular and Humoral Alloreactivity and Predicts Inferior Graft Outcome

    M. Meneghini1, E. Crespo2, M. Niemann3, A. Torija2, E. Melilli4, M. Jarque2, N. Montero4, J. Cruzado1, J. Grinyo1, O. Bestard1

    1Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 2Experimental Nephrology Laboratory, IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, 3PIRCHE AG, Berlin, Germany, 4Kidney Transplantation Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat. Barcelona, Spain

    *Purpose: PIRCHE-II algorithm predicts mismatched donor-derived HLA peptides number presented on recipient HLAclass-II molecules to recipient T-cells (indirect pathway of allorecognition) and has been associated…
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