Am J Transplant, Volume 19, Suppl 3 Archives - Page 3 of 214 - ATC Abstracts

2019 American Transplant Congress
Clazakizumab as an Agent to Reduce Donor Specific HLA Antibodies and Improve Outcomes in Patients with Chronic & Active Antibody-Mediated Rejection Post-Kidney Transplantation
S. C. Jordan¹, N. Ammerman¹, M. Toyoda², E. Huang¹, C. C. Nast³, A. Peng¹, S. Sethi¹, R. Najjar¹, I. Kim¹, K. Lim¹, J. Choi¹, A. Vo¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Ctr, Los Angeles, CA, ²Transplant Immunology Lab, Cedars-Sinai Medical Ctr, Los Angeles, CA, ³Department of Pathology, Cedars-Sinai Medical Ctr, Los Angeles, CA
*Purpose: Highly sensitized (HS) patients are at an increased risk for chronic antibody mediated rejection (cABMR) and graft loss due to persistent, deleterious DSA production.…
2019 American Transplant Congress
Letermovir For The Treatment And Secondary Prophylaxis Of Drug Resistant CMV In Solid Organ Transplant Recipients
M. R. Pereira¹, J. G. Aaron¹, C. J. Kubin²
¹Medicine - Infectious Diseases, Columbia University Medical Center, New York, NY, ²Medicine - Infectious Diseases, NewYork Presbyterian Hospital, New York, NY
*Purpose: Although only approved for primary prophylaxis of CMV among allogeneic stem cell transplant recipients, there is great interest in the use of letermovir (LET)…
2019 American Transplant Congress
Antithymocyte Globulin is Associated with Mature T Cell Phenotypes and Decreased Risk of Non-EBV Infections in Transplanted Children
B. I. Shaw¹, L. Stempora¹, C. Chan¹, R. B. Ettenger², P. C. Grimm³, H. Lee¹, E. F. Reed², M. M. Sarwal⁴, B. L. Warshaw⁵, C. Zhao¹, O. M. Martinez³, A. D. Kirk¹, E. T. Chambers¹
¹Pediatrics/Surgery, Duke University, Durham, NC, ²Pediatrics, University of California, Los Angeles, Los Angeles, CA, ³Pediatrics/Surgery, Stanford University, Palo Alto, CA, ⁴Pediatrics/Surgery, University of California, San Francisco, San Francisco, CA, ⁵Pediatrics, Emory University, Atlanta, GA
*Purpose: Depletional induction therapies are known to reduce the rate of acute rejection; yet data from the US Renal Data System have shown that use…
2019 American Transplant Congress
The Protective Effects of siRNA Conjugated Nanoparticles in Pancreatic Islet Cells after Transplant
T. Pomposelli, P. Wang, Y. Ariyoshi, K. Takeuchi, C. Schuetz, A. Moore, K. Yamada
Columbia Center for Translational Immunology, Columbia University, New York, NY
*Purpose: To utilize a novel technology involving siRNA conjugated iron oxide nanoparticles to protect against ischemic damage to islet cells before transplant, therefore minimizing the…
2019 American Transplant Congress
Risk Factors to Define an Extended Criteria Donor Heart Do Not Appear to Have Cumulative Adverse Effects after Heart Transplantation
M. Olymbios, S. Dimbil, R. J. Levine, F. Esmailian, J. Patel, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: There remains a disparity between the number of patients awaiting heart transplantation (HTx) and the availability of donor hearts. This is exacerbated by relatively…
2019 American Transplant Congress
Polymorphisms in Mycophenolate Mofetil Glucuronidation Gene Are Associated with Leukopenia and Decreased CLAD-Free Survival
A. Barnes, D. R. Calabrese, E. Henricksen, R. Florez, K. Dewey, P. Wang, J. Teraoka, K. Lien, S. Hays, J. P. Singer, J. Golden, J. Kukreja, J. R. Greenland
UCSF Medical Center, San Francisco, CA
*Purpose: Lung transplant recipients vary in their tolerance of the immunosuppressant mycophenolate mofetil (MMF). Single nucleotide polymorphisms (SNPs) in UDP-glucuronosyltransferase 2B7 (UGT2B7) increase conversion of…
2019 American Transplant Congress
Association Of Kdpi And Dgf With Dcd Kidney Transplants Outcomes
M. Sampaio, B. Abdalla, S. Bunnapradist
David Geffen Sch of Med at UCLA, Los Angeles, CA
*Purpose: Donors of circulatory death (DCD) have similar outcomes compared to donors of brain death (DBD) in kidney transplants. It is unclear if this is…
2019 American Transplant Congress
Unique Gene Expression Signatures in Urine Distinguish T Cell Mediated Acute Rejection from BK Virus Nephropathy in Kidney Transplant Patients
K. S. Keslar¹, W. Xu², A. A. Zmijewska³, K. A. Newell⁴, J. J. Friedewald⁵, M. I. Abecassis⁵, P. S. Heeger⁶, J. S. Bromberg⁷, R. B. Mannon³, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Nanostring Technologies, Seattle, WA, ³Univ. Alabama Birmingham, Birmingham, AL, ⁴Emory Univ., Atlanta, GA, ⁵Northwestern Univ., Chicago, IL, ⁶Icahn School of Med., New York, NY, ⁷Univ. Maryland, Baltimore, MD
*Purpose: There is a need to develop non-invasive approaches to detect ongoing kidney graft injury and distinguish immune from non-immune inflammation to guide therapy. Ideally…
2019 American Transplant Congress
Maternal and Pregnancy Outcomes after Living Donor Nephrectomy in a Multistate Cohort
G. S. Lee¹, R. X. Wang², D. O. Walls³, P. P. Reese⁴, D. S. Goldberg⁴, P. L. Abt¹
¹Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Sidney Kimmel Medical College, Philadelphia, PA, ³Surgery, Rutgers Robert Wood Johnson, New Brunswick, NJ, ⁴Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Studies have demonstrated increased risk of preeclampsia for pregnancies after kidney donation in homogenous populations or single-center studies. Our study aims to delineate maternal…
2019 American Transplant Congress
Nationwide Survey of Human T Cell Leukemia Virus Type 1-Infected Kidney Transplant Recipients in Japan
J. Yamauchi¹, Y. Yamano¹, M. Matsuoka², N. Ichimaru³, M. Nishikido⁴, Y. Shibagaki⁵, A. Sugitani⁶, N. Nakamura⁷, M. Mieno⁸, K. Yuzawa⁹
¹Department of Rare Diseases Research, Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, ²Institute for Virus Research, Kyoto University, Kyoto, Japan, ³Advanced Technology for Transplantation, Osaka University, Osaka, Japan, ⁴Blood Purification Center, Nagasaki University, Nagasaki, Japan, ⁵Department of Nephrology and Hypertention, St. Marianna University School of Medicine, Kawasaki, Japan, ⁶NHO Yonago Medical Center, Yonago, Japan, ⁷Fukuoka University, Fukuoka, Japan, ⁸Center for Information, Jichi Medical University, Shimotsuke, Japan, ⁹Department of Transplantation Surgery, National Hospital Organization Mito Medical Center, Ibaraki, Japan
*Purpose: Human T-cell leukemia virus type 1 (HTLV-1) infects 5 to 10 million people worldwide, and is endemic in Japan, sub-Saharan Africa, South America, and…