Am J Transplant, Volume 19, Suppl 3 Archives - Page 24 of 214 - ATC Abstracts

2019 American Transplant Congress
Retrospective Evaluation of Optimal Cmv Prophylaxis Regimens in Lung Transplant Patients: Analysis of Patient Outcomes Pre and Post Protocol Dosing Alterations
J. Hunt, A. Nasar, R. Walia, L. Cherrier
St. Joseph Hospital and Medical Center, Phoenix, AZ
*Purpose: Given the heightened risk of cytomegalovirus (CMV) following lung transplantation compared to other solid organ transplants, with minimal evidence based guidance specific to this…
2019 American Transplant Congress
RNA Splicing and Lineage Progression: Identification of an Integrated Splicing Pattern in Endodermal Lineage Progression
J. Fair¹, N. Liu¹, S. G. Widen², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX
*Purpose: Epigenetic states such as histone modifications and DNA methylation that influence transcription are well-characterized regulators of stem cell pluripotency and differentiation to specific lineages.…
2019 American Transplant Congress
T Cell-Intrinsic Dysfunction in Donor-Specific Transplantation Tolerance
C. M. McIntosh¹, M. L. Miller², Y. Wang¹, A. Chong³, M. Alegre¹
¹Department of Medicine, University of Chicago, Chicago, IL, ²Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ³Department of Surgery, University of Chicago, Chicago, IL
*Purpose: Donor-specific tolerance offers many advantages over current lifelong non-specific immunosuppression strategies, but the mechanisms by which it may be durably maintained remain to be…
2019 American Transplant Congress
Role of RIPK3 in Chronic Rejection Following Human Lung Transplantation
S. Angara, R. Ravichandran, H. Sodawalla, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Immunological mechanisms leading to chronic rejection, bronchiolitis obliterans syndrome (BOS), following human lung transplantation remains unclear though a strong correlation have been identified between…
2019 American Transplant Congress
Poor Outcomes in Kidney Transplant Candidates & Recipients with History of Falls
N. Chu¹, H. Ying¹, Z. Shi¹, C. Haugen¹, S. Norman², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins, Baltimore, MD, ²Michigan Medical Center, Ann Arbor, MI
*Purpose: In patients with ESRD, serious fall injuries (e.g. fractures) are associated with decreased chance of listing or transplantation. It is likely that KT candidates…
2019 American Transplant Congress
Impact of Donor Hepatitis C Virus Infection on Kidney Transplant Outcomes in the Direct Acting Antiretroviral Era: Time to Revise the KDPI?
R. M. Cannon, E. G. Davis, L. Mackelaite, H. Dave, M. Eng, C. M. Jones
University of Louisville, Louisville, KY
*Purpose: The kidney donor risk index (KDRI), upon which the kidney donor profile index (KDPI) used for renal allocation is based, was derived before the…
2019 American Transplant Congress
Eight-Year Outcomes Following ABO-Incompatible Kidney Transplantation Performed after Desensitization by Antigen-Unspecific Immunoadsorption Devices
C. Speer¹, F. Kälble¹, L. Pego da Silva¹, C. Nusshag¹, M. Schaier¹, C. Süsal², C. Sommerer¹, M. Zeier¹, C. Morath¹
¹Nephrology, University of Heidelberg, Heidelberg, Germany, ²Immunology, University of Heidelberg, Heidelberg, Germany
*Purpose: Owing to the unmet need of available kidney grafts, ABO-incompatible kidney transplantation (KTX) has been established to enlarge the possible donor pool. The current…
2019 American Transplant Congress
Risk Factors for 1-5 Year De Novo Cancers after Kidney Transplant (KTx) with First-Year Immunosuppression (IS) Data: An Analysis of the Choosing Immune Suppression by Efficacy and Morbidity (CISTEM) Study
V. Dharnidharka¹, D. Axelrod², Z. Zhang³, M. Schnitzler³, K. Lentine³, B. Kasiske⁴
¹Washington Univ, St. Louis, MO, ²Univ of Iowa, Iowa City, IA, ³Saint Louis Univ, St. Louis, MO, ⁴SRTR, Minneapolis, MN
*Purpose: From our CISTEM study of linked national registries, we published data on risk factors for within-3-years post-KTx non-melanoma skin cancer (NMSC) and viral-driven cancers…
2019 American Transplant Congress
Microparticle Delivery to Lymph Nodes Induces Specific Suppression to Prolong Islet Survival
Y. Xiong¹, L. Tostanoski², C. Jewell³, J. Bromberg¹
¹Surgery, U. Maryland, Baltimore, MD, ²U.Maryland, Baltimore, MD, ³U. Maryland, College Park, MD
*Purpose: Microparticles (MP) loaded with peptide antigen plus other immune signals and delivered directly into lymph nodes (LN) can result in either proinflammatory or antiinflammatory…
2019 American Transplant Congress
Minimizing Kidney Ischemia Reperfusion Injury by Transferring Exogenous Mitochondria
A. Bajwa¹, V. Bontha¹, J. Eason², D. Maluf³, V. Mas⁴
¹UT, Memphis, TN, ²Director of Transplant Institute. UTHSC, Memphis, TN, ³UTHSC, Memphis, TN, ⁴Director of Transplant Research Institute. UTHSC, Memphis, TN
*Purpose: Ischemia induces altered bioenergetics with increased mitochondrial swelling and reactive oxygen species (ROS) and ultimately degradation of cellular function. Ischemia followed by reperfusion (IRI)…