Am J Transplant, Volume 19, Suppl 3 Archives - Page 206 of 214 - ATC Abstracts

2019 American Transplant Congress
IgG4 Subclass Class 2 Donor Specific Antibody (DSA) is Associated with Subclinical Rejection in Stable Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests
A. Jackson¹, S. Kanaparthi², B. Burrell³, D. Lucas⁴, R. Vega⁴, A. J. Demetris⁵, S. Feng⁶
¹Surgery, Duke University, Durham, NC, ²The Immune Tolerance Network, Bethesda, MD, ³Immune Tolerance Network, Bethesda, MD, ⁴Medicine, Johns Hopkins University, Baltimore, MD, ⁵Pathology, University of Pittsburgh, Pittsburgh, PA, ⁶Surgery, University of California San Francisco, San Francisco, CA
*Purpose: DSA is a known biomarker of allograft rejection, yet injury phenotype and potential differ across organs. Among pediatric LT recipients entering iWITH (NCT01638559), an…
2019 American Transplant Congress
Impact of Cytomegalovirus on the Immune System of Healthy Humans
W. Zhang, J. Robertson, G. Karadkhele, B. Johnson, C. Larsen
Emory Transplant Center, Emory University, Atlanta, GA
*Purpose: CMV is a frequent pathogen after transplantation. 2/3 of recipients harbor latent CMV and are at moderate risk. CMV- recipients divide into high or…
2019 American Transplant Congress
Ligation Of Hla Class Il Molecules Disrupts Endothelial Barrier Through Src-dependent Ve-cadherin Destabilization
F. Li¹, R. A. Sosa¹, N. M. Valenzuela¹, E. Rozengurt², E. F. Reed¹
¹Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ²Digestive Diseases Research Center, University of California, Los Angeles, Los Angeles, CA
*Purpose: Microvascular inflammation, vascular permeability, and accumulation of intravascular mononuclear cells are characteristics of acute and chronic antibody-mediated rejection. Vascular endothelial cadherin (VE-Cadherin) is a…
2019 American Transplant Congress
Incidence and Risk of Allograft Rejection after Cardiac Transplantation in Left Ventricular Assist Device Patients
R. C. Patel¹, L. B. Cooper², S. D. Barnett², R. T. Cole², M. A. Psotka², A. Cochrane², S. Sinha², L. J. Bogar², S. S. Desai², P. Shah²
¹Virginia Commonwealth University School of Medicine, Inova Fairfax Hospital, Falls Church, VA, ²Department of Heart Failure and Transplant, Inova Heart and Vascular Institute, Falls Church, VA
*Purpose: Left ventricular assist devices (LVAD) are made of biomaterials that have been shown to cause allosensitization. Single center studies have suggested that patients bridged…
2019 American Transplant Congress
Early Steroid Withdrawal in African American Deceased Donor Renal Transplant Recipients with Alemtuzumab Induction: Is Graft Loss on the Horizon?
R. Lynn, B. Ravichandran, T. Sparkes, A. Haririan, J. Bromberg, J. Casale
University of Maryland Medical Center, Baltimore, MD
*Purpose: The safety of early steroid withdrawal (ESW) in African American (AA) deceased donor renal transplant recipients (DDRTs) is unclear. This study assessed the impact…
2019 American Transplant Congress
The Evolution of Body Mass Index after Kidney Transplantation in Recipients with a Previous Laparoscopic Sleeve Gastrectomy
G. Chan, F. Briere
Universite de Montreal, Hopital Maisonneuve-Rosemont, Montreal, QC, Canada
*Purpose: Bariatric surgery is one of the most common operations. Laparoscopic sleeve gastrectomy (LSG) has been reported to prepare candidates for listing. However, weight gain…
2019 American Transplant Congress
Transplant Center Practices Are the Primary Drivers of United States Donation after Circulatory Death Liver Transplantation
L. Beal¹, D. T. Nguyen², T. Menser³, S. Zajac¹, E. A. Graviss², M. J. Hobeika¹
¹Department of Surgery, Houston Methodist Hospital, Houston, TX, ²Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX, ³Center for Outcomes Research, Houston Methodist Research Institute, Houston, TX
*Purpose: We hypothesize that a few high-utilization donation after circulatory death (DCD) liver centers are the primary drivers of the dissimilar rates of DCD liver…
2019 American Transplant Congress
Role of MHC Class II in B Cell and Regulatory T Cell Development
S. K. Germana, Z. Wang, C. A. Huang, L. Kojima, C. G. Rickert, J. F. Markmann, C. LeGuern
Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Therapies involving CD4 regulatory T cells (Tregs) are promising approaches to mitigate graft rejection and autoimmunity. Understanding of the activation mechanisms that initiate Treg…
2019 American Transplant Congress
B Cell-Specific IRE1a Deficiency Protects Renal Allografts from Rejection via Inhibition of Donor-Specific Antibodies and Induction of B Regulatory Cells
L. Qiu¹, J. Wang¹, X. Yeap¹, D. Fang², Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Despite the progress in immunosuppressive regimens, antibody-mediated rejection remains a major contributor to renal allograft loss in recipients with donor-specific antibodies (DSA). IRE1a, an…
2019 American Transplant Congress
Alcohol Recidivism In Liver Transplant Recipients With Alcoholic Liver Disease: Does Six-months Abstinence Rule Still Holds True?
S. K. Satapathy¹, C. Thornburgh¹, J. Yu², J. Eason¹, S. Kedia², D. Maluf¹
¹UTHSC, Memphis, TN, ²University of Memphis, Memphis, TN
*Purpose: Liver transplant for alcoholic liver disease (ALD) continues to be a challenge for transplant centers, particularly related to the ethical dilemma of transplanting or…