Am J Transplant, Volume 19, Suppl 3 Archives - Page 204 of 214 - ATC Abstracts

2019 American Transplant Congress
First Report and Mechanistic Analysis of Operational Tolerance after Intestinal Transplant
J. Weiner¹, S. Moturi¹, C. Ashokkumar², K. Khan¹, S. Kaufman¹, R. Sindhi², C. Matsumoto¹, T. Fishbein¹, A. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²University of Pittsburgh, Pittsburgh, PA
*Purpose: Transplantation tolerance is a highly sought and rarely achieved state in clinical medicine. Defined as long-term stable and acceptable graft tolerance without immunosuppression and…
2019 American Transplant Congress
Vo_2peakSuperior to Current Established Measure of Post Kidney Transplant Survival Score (EPTS Score)
H. Chakkera¹, R. Butterfield¹, M. Buras¹, B. Kaplan²
¹Mayo Clinic Hospital, Phoenix, AZ, ²Baylor Scott and White, Dallas, TX
*Purpose: The Scientific Registry of Transplant Recipients (SRTR) utilizes the calculated estimated posttransplant survival (EPTS) score as the measure of post kidney transplant survival to…
2019 American Transplant Congress
Early Impact of the New United Network for Organ Sharing Simultaneous Liver-Kidney Transplantation Allocation Policy: Improved Standardization but Similar Utilization
G. Cullaro¹, E. C. Verna², J. C. Lai¹
¹UCSF, San Francisco, CA, ²Columbia University, New York, NY
*Purpose: In an effort to standardize SLKT utilization, UNOS/OPTN implemented a new SLKT policy on August 10th, 2017. We aimed to characterize the early impact…
2019 American Transplant Congress
Halt-hcc At The Time Of Listing Is Superior To Other Allocation Metrics At Predicting Waitlist Dropout; An Srtr Analysis
J. C. McVey¹, K. Sasaki¹, D. J. Firl², C. M. Miller¹, K. Hashimoto¹, C. Quintini¹, F. N. Aucejo¹
¹Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, ²Department of General Surgery, Duke University, Durham, NC
*Purpose: A recently developed liver allocation metric, Hazard Associated with Liver Transplant for Hepatocellular Carcinoma (HALT-HCC), has been shown to predict post-transplantation survival and recurrence.…
2019 American Transplant Congress
Outcomes and Clinical Utility of the kSORT Assay in the Prism Prospective Clinical Trial of Highly Sensitized Kidney Transplant Recipients
A. Schroeder, P. Towfighi, C. Hu, S. Hsieh, J. Liberto, I. Damm, T. Sigdel, P. Millar, M. Sarwal, F. Vincenti
Department of Surgery, UCSF, San Francisco, CA
*Purpose: kSORT, a 17 gene blood biomarker, has been retrospectively validated for detection of biopsy proven acute rejection (AR) and immune quiescence in kidney transplantation…
2019 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Preservation Consistently Improves Extreme Marginal Graft Function Compared to Hypothermic Machine Perfusion
P. Urbanellis¹, M. Hamar¹, I. Linares¹, D. Kollmann¹, S. Ganesh¹, F. Oquendo¹, M. Sharma¹, R. John¹, A. Ghanekar¹, I. Mucsi¹, D. Bagli², A. Konvalinka¹, L. Robinson³, M. Selzner¹
¹Multi-Organ Transplantation Program, University Health Network, Toronto, ON, Canada, ²Division of Urology, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP promoted improved marginal graft function compared to…
2019 American Transplant Congress
Women Who Undergo Liver Transplant Have Increased Health Care Utilization in the Peri-Transplant Period Compared with Men
J. B. Rubin, G. Cullaro, J. Ge, J. C. Lai
Department of Medicine, Division of Gastroenterology & Hepatology, Univeristy of California-San Francisco, San Francisco, CA
*Purpose: We have previously shown that women on the liver transplant (LT) waitlist are at greater risk of hospitalization compared with men, but whether this…
2019 American Transplant Congress
Intact Lymphatics Are Essential for Costimulation Blockade-Induced Lung Allograft Survival
L. Wang¹, H. Reed², R. Han¹, M. Kahn², W. W. Hancock¹
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA
*Purpose: Blocking lymphangiogenesis is thought to diminish immune responses to donor tissues. However, lung transplantation (Tx), which involves airway and vascular but not lymphatic anastomoses,…
2019 American Transplant Congress
Depletional Induction Therapy in Non-Human Primates – Preclinical Modeling of Polyclonal Depletion with Rhesus-Specific ATG
R. Schmitz¹, M. S. Mulvihill¹, P. M. Schroder¹, Z. Fitch¹, F. Leopardi¹, D. Magnani², J. Kwun¹, S. J. Knechtle¹, A. D. Kirk¹
¹Surgery, Duke University Medical Center, Durham, NC, ²University of Massachusetts Medical School, Boston, MA
*Purpose: Antithymocyte globulins (ATG) have been used in transplantation since the late 1960s to prevent and treat acute allograft rejection. Over the past decade, induction…
2019 American Transplant Congress
Effects of Standard Drug Immunosuppression on Peripheral Transitional B Cells and Gene Expression in Non-Human Primates
A. Bean¹, J. Paster¹, K. Pruner¹, J. O¹, W. Sommer², K. Robinson³, I. Hanekamp¹, G. Benichou¹, J. Madsen¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Klinik fur Herz Thorax Transplantation, Medizinische Hochschule Hannover, Hannover, Germany, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: Operationally tolerant renal transplant recipients exhibit an increased number of transitional B cells and an upregulation of selected B-cell associated genes in the periphery…