Am J Transplant, Volume 19, Suppl 3 Archives - Page 204 of 214 - ATC Abstracts

2019 American Transplant Congress
Inflammation and Fibrosis Are Observed in 34% of Clinically Stable Adult Liver Transplant Recipients
L. Sun¹, J. Levitsky², S. Feng³, A. Humar⁴, A. J. Demetris⁴, J. Emond⁵, A. Shaked⁶, G. Klintmalm⁷, K. Mason⁸, M. DesMarais¹, A. Priore⁹, N. Bridges⁹, B. E. Burrell¹⁰, S. Chandran³, J. Markmann¹¹
¹ITN, San Francisco, CA, ²Northwestern, Chicago, IL, ³UCSF, San Francisco, CA, ⁴UPMC, Pittsburg, PA, ⁵Columbia, New York, NY, ⁶UPenn, Philadelphia, PA, ⁷Baylor, Dallas, TX, ⁸Rho, Chapel Hill, NC, ⁹NIAID, Bethesda, MD, ¹⁰ITN, Bethesda, MD, ¹¹MGH, Boston, MA
*Purpose: OPTIMAL is a 7-center immunosuppression withdrawal (ISW) study in non-autoimmune, non-HCV adult liver transplant recipients ≥3 yrs post-transplant (tx) (NCT02533180). Subjects underwent a screening…
2019 American Transplant Congress
Outcomes Analysis of U.S. Transplant Centers Performing High Volumes of Hard to Place Kidneys
Y. Qazi¹, D. Bahl², N. Mehta³, Z. Haddad⁴, M. Smogorzewski⁴
¹USC, Los Angeles, CA, ²UC Davis, Sacramento, CA, ³UC Berkeley, Berkeley, CA, ⁴Keck Medical Center At USC, Los Angeles, CA
*Purpose: Despite a growing number of patients awaiting a kidney transplant, discard rate remains significantly high. The UNOS SRTR data now provides information on all…
2019 American Transplant Congress
Breaking Concepts: 10-year Follow-Up of the Everolimus versus Azathioprine Heart Transplant Multi-National Study
J. A. Kobashigawa¹, R. Starling², E. Passano¹, P. Bernhardt³, B. Azarbal¹, R. Cheng¹, F. Esmailian¹, K. Khush⁴, D. Mancini⁵, J. Patel¹, T. Sato¹, S. Varnous⁶
¹Smidt Heart Institute at Cedars-Sinai, Los Angeles, CA, ²Cleveland Clinic, Cleveland, OH, ³Novartis Pharmaceuticals, Basel, Switzerland, ⁴Stanford University, Palo Alto, CA, ⁵Mount Sinai, New York, NY, ⁶APHP, Pitié‐Salpétrière, Sorbonne University, Paris, France
*Purpose: This study is the 10-year follow-up of a randomized double-blind prospective trial that compared everolimus (1.5 mg or 3 mg) to azathioprine. In this…
2019 American Transplant Congress
Effects of IVIG Therapy and FcγR Polymorphisms on BK Virus Nephropathy in Kidney Transplant Recipients
D. I. Min¹, Y. Chang², T. Shah³
¹Western Univ of Health Sciences, Los Angeles, CA, ²Mendez National Institute of Transplantation Foundation, Los Angeles, CA, ³St. Vincent Medical Center, Los Angeles, CA
*Purpose: BK Virus Nephropathy (BKVN) is a major complication in kidney transplant patients. Although standard treatment for BKVN is immunosuppression reduction and/or using leflunomide, studies…
2019 American Transplant Congress
Generation of Thymic Epithelial Cells from Induced Pluripotent Stem Cells to Prolong Allograft Survival
R. Otsuka, H. Wada, H. Tsuji, A. Sasaki, T. Murata, M. Baghdadi, K. Seino
Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
*Purpose: Pluripotent stem cell (PSC) is a potential source of generating functional therapeutic cells for transplantation. Embryonic stem cells are of absolutely allogeneic origin. Induced…
2019 American Transplant Congress
Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes
B. Motyka¹, J. Fersovich¹, M. Sulzer¹, I. Adam¹, J. Pearcey¹, K. Tao¹, C. W. Cairo², P. J. Cowan³, L. J. West¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada, ²Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ³Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia
*Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…
2019 American Transplant Congress
Indicators of Impending Pig Organ Xenograft Failure: Relevance to Clinical Xenotransplantation
H. Iwase¹, A. Jagdale¹, T. Yamamoto¹, G. Zhang¹, Q. Li¹, J. Foote¹, D. Ayares², H. Hara¹, D. K. Cooper¹
¹University of Alabama at Birmingham, Birmingham, AL, ²Revivicor, Inc., Blacksburg, VA
*Purpose: In pig-to-baboon organ xenotransplantation, coagulation dysfunction and inflammation have been suggested to be associated with acute humoral xenograft rejection. We have evaluated platelet counts,…
2019 American Transplant Congress
Role of Innate Allorecognition Pathways in Mouse Renal Allograft Rejection
D. Zhao¹, H. Dai¹, K. Abou-Daya¹, A. Williams¹, M. Oberbarnscheidt¹, X. Li², F. Lakkis¹
¹Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ²Houston Methodist Hospital Immunobiology & Transplant Science Center, Houston, TX
*Purpose: Allograft rejection is initiated by host immune system distinguishing between self and allogeneic non-self (allorecognition). Paired immunoglobulin-like receptor (PIR) and CD47 are molecules expressed…
2019 American Transplant Congress
Longer-Term Outcomes for Hepatitis C Virus Negative Recipients of Kidneys from Hepatitis C Virus Nucleic Acid Test Positive Donors: The THINKER Trial
P. Reese¹, P. Abt¹, E. Blumberg¹, R. Bloom¹, D. Sawinski¹, P. Porrett¹, A. Woodards¹, K. Reddy¹, V. van Deerlin¹, R. Hasz², M. Levine¹, R. McLean¹, A. Sicilia¹, D. Goldberg¹
¹University of Penn, Philadelphia, PA, ²Gift of Life, Philadelphia, PA
*Purpose: Two trials of transplanting hepatitis C virus (HCV) nucleic acid test (NAT) positive kidneys into HCV-negative recipients have been published, both with 100% HCV…
2019 American Transplant Congress
Robotic-Assisted versus Open Techniques for Living Donor Kidney Transplant Recipients: A Comparison Using Propensity Score Analysis
F. Tinney, J. Stracke, S. Nagai, L. Malinzak, T. McEvoy, S. Mohamed Ilias, A. Yoshida
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: Following rapid advancements in minimally invasive urology, living donor robotic-assisted kidney transplantation (RAKT) has developed into a feasible alternative to open kidney transplantation (OKT).…