Am J Transplant, Volume 19, Suppl 3 Archives - Page 197 of 214 - ATC Abstracts

2019 American Transplant Congress
Targeted Epitope Mutagenesis as a Strategy to Decrease Xenoantibody Binding
J. Ladowski, G. Martens, Z. Wang, L. Reyes, M. Tector, J. Tector
University of Alabama-Birmingham, Birmingham, AL
*Purpose: Xenotransplantation, the use of genetically-modified pig organs for transplantation, has been limited by antibody-mediated rejection. The generation of a three-antigen knockout pig provided a…
2019 American Transplant Congress
Bcl-2 Inhibition with Venetoclax Promotes Induction of Mixed Chimerism and Renal Allograft Tolerance without Severe Myelosuppression in Non-Human Primate
H. Sasaki¹, D. Ma¹, T. Oura¹, A. Dehnadi¹, I. Rosales², B. Cosimi¹, P. Cippa³, T. Fehr³, T. Kawai¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology, Massachusetts General Hospital, Boston, MA, ³Medicine, University of Zurich, Zurich, Switzerland
*Purpose: Specific Bcl-2 inhibition has been shown to promote mixed chimerism and skin allograft tolerance without myelosuppressive conditioning in murine models. To extend this approach…
2019 American Transplant Congress
Hope in Action: A Multicenter Prospective Study of HIV to HIV Kidney Transplantation
C. Durand¹, S. Huprikar², M. Bowring³, D. Brown¹, B. Haydel⁴, N. Desai³, F. Naqvi¹, R. Friedman-Moraco⁵, N. Turgeon⁶, V. Stosor⁷, J. Charette⁷, S. Mehta⁸, J. Husson⁹, A. Gilbert¹⁰, M. Cooper¹¹, C. Butkus-Small¹², G. Gupta¹³, S. Mehta¹⁴, O. Adebiyi¹⁵, P. Chin-Hong¹⁶, P. Stock¹⁷, A. Massie³, S. Florman⁴, D. Segev³
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Medicine, Mount Sinai, New York, NY, ³Surgery, Johns Hopkins University, Baltimore, MD, ⁴Surgery, Mount Sinai, New York, NY, ⁵Medicine, Emory University, Atlanta, GA, ⁶Surgery, Emory University, Atlanta, GA, ⁷Medicine, Northwestern University, Chicago, IL, ⁸Medicine, University of Alabama, Birmingham, AL, ⁹Medicine, University of Maryland, Baltimore, MD, ¹⁰Medicine, Georgetown University, Washington DC, DC, ¹¹Department of Surgery, Georgetown University, Washington DC, DC, ¹²Medicine, Cornell University, New York, NY, ¹³Medicine, Virginia Commonwealth University, Richmond, VA, ¹⁴Medicine, New York University, New York, NY, ¹⁵Medicine, Indiana University, Indianapolis, IN, ¹⁶Medicine, University of California at San Francisco, San Francisco, CA, ¹⁷Surgery, University of California at San Francisco, San Francisco, CA
*Purpose:HIV+ donor to HIV+ recipient (HIV D+/R+) kidney transplantation (KT) has had success in South Africa. Expansion of this practice in the US setting of…
2019 American Transplant Congress
Robotic Assisted Kidney Transplant Outcomes in Obese Candidates
I. G. Tzvetanov, K. A. Tulla, O. T. Okoye, C. Di Bella, P. Di Cocco, J. A. Almario Alvarez, M. Spaggiari, E. Benedetti
University of Illinois at Chicago, Chicago, IL
*Purpose: The dialysis dependent patient population is growing more obese and finding innovative ways to make them transplant candidates is important. Here in we demonstrate…
2019 American Transplant Congress
Immune Cell Types and Host Gene Signatures Associated with Epstein-Barr Virus (EBV) Post-Transplant Lymphoproliferative Disorder (PTLD)
J. Toh¹, F. Vallania¹, W. A. Haynes¹, G. Bhagat², F. E. Craig³, S. H. Swerdlow⁴, T. Tousseyn⁵, S. M. Krams¹, P. Khatri¹, O. M. Martinez¹
¹Stanford University School of Medicine, Stanford, CA, ²Columbia University Medical Center, New York, NY, ³Mayo Clinic College of Medicine, Phoenix, AZ, ⁴University of Pittsburgh School of Medicine, Pittsburg, PA, ⁵Katholieke Universiteit Leuven, Leuven, Belgium
*Purpose: PTLD is a serious post-transplant complication that encompasses a range of abnormal lymphoproliferations, including EBV+ B cell lymphomas. Although many are EBV-driven, a significant…
2019 American Transplant Congress
Shroom3 Regulates Glomerular Hypertrophy after Uninephrectomy via mTOR
K. Banu, F. Garzon, C. Wei, Z. Yi, W. Zhang, C. He, B. Murphy, M. C. Menon
Mount Sinai School of Medicine, New York, NY
*Purpose: A Shroom3 intronic risk locus & Shroom3 protein have been associated with increased fibrosis but reduced albuminuria in recipients of allografts with the risk…
2019 American Transplant Congress
Use of Low Dose Interleukin-2 to Expand Regulatory T-cells and Facilitate the Complete Discontinuation of Immunosuppression in Human Liver Transplantation
T. Lim¹, P. Ruiz², A. Kurt², E. Kodela², M. Martinez-Llordella², T. Tree³, A. Sanchez-Fueyo¹
¹Institute of Liver Studies, King's College Hospital, London, United Kingdom, ²Department of Liver Sciences, King's College London, London, United Kingdom, ³Department of Immunobiology, King's College London, London, United Kingdom
*Purpose: Low dose interleukin-2 (LDIL-2) is capable of expanding endogenous CD4+CD25+FoxP3+ regulatory T-cells (Tregs) in vivo but its role in human solid organ transplantation is…
2019 American Transplant Congress
Brief Normothermic Machine Perfusion is Superior to Cold Storage Alone – A Paired Discarded Human Kidney Analysis
A. Hameed¹, E. Patrick², D. B. Lu¹, C. P'ng¹, M. Hu², Y. Chew², R. De Roo¹, L. Yuen¹, W. Hawthorne¹, N. Rogers¹, H. Pleass¹
¹Westmead Hospital, Sydney, Australia, ²Westmead Institute for Medical Research, Sydney, Australia
*Purpose: The use of marginal has increased due to ongoing donor shortages. These kidneys have higher rates of graft discard after procurement, and also have…
2019 American Transplant Congress
Efficacy and Safety with Empagliflozin in Renal Transplant Recipients with Post-Transplant Diabetes Mellitus
K. E. Kvitne¹, T. S. Halden², A. Åsberg², K. Midtvedt², A. Hartmann², T. Jenssen²
¹Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, Oslo, Norway, ²Department of Transplantation Medicine, Section of Nephrology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
*Purpose: Post-transplant diabetes mellitus (PTDM) is a highly prevalent condition following renal transplantation, associated with increased risk of cardiovascular disease and impaired patient survival. Sodium-glucose…
2019 American Transplant Congress
Undernutrition is Associated with Impaired T Cell Protective Immunity in Pediatric Kidney Transplantation
E. T. Chambers¹, C. Chan¹, R. Ettenger², P. Grimm³, E. Reed², M. Sarwal⁴, L. Stempora⁵, B. Warshaw⁶, C. Zhao¹, O. Martinez⁷, A. Kirk⁵
¹Pediatrics, Duke University, Durham, NC, ²Pediatrics, UCLA, Los Angeles, CA, ³Pediatrics, Stanford, Palo Alto, CA, ⁴Pediatrics, UCSF, San Francisco, CA, ⁵Surgery, Duke University, Durham, NC, ⁶Pediatrics, Emory University, Atlanta, GA, ⁷Surgery, Stanford, Palo Alto, CA
*Purpose: Undernutrition has been associated with T cell immune cell dysfunction and infectious complications in non-immunosuppressed children. Thus, we aimed to define T cell phenotypes…