ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    The Use of Native Kidney Biopsy to Predict Renal Dysfunction Following Liver Transplantation

    D. O. Walls1, L. Muraveika1, M. B. Palmer2, D. L. Sawinski3, B. J. Keating1, P. L. Abt1

    1Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, 2Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA, 3Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA

    *Purpose: Acute and chronic kidney injury are a common occurrence for patients with end-stage liver disease and are associated with significant morbidity and mortality. We…
  • 2019 American Transplant Congress

    Single Nucleotide Polymorphisms in NFACT1 rs2290154 Associated with the Risk of T Cell-Mediated Rejection of Recipients Following Kidney Transplantation

    Z. Wang, S. Fei, H. Chen, L. Sun, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

    No.300 Guangzhou Road of Nanjing, Nanjing, China

    *Purpose: Our study was to investigate the potential associations between the single nucleotide polymorphisms (SNPs) in NFATC1 and the risk of T cell-mediated rejection (TCMR)…
  • 2019 American Transplant Congress

    Hepatitis C Treatment and Transplant Outcomes in Liver Transplant Recipients with Hepatitis C Positive Donors

    I. Booth, J. Clark, J. C. LaMattina, A. Haririan, R. N. Barth, B. Ravichandran

    University of Maryland Medical Center, Baltimore, MD

    *Purpose: With direct-acting antivirals for hepatitis C virus (HCV), transplant centers have expanded the donor pool with positive short term outcomes with early HCV treatment.…
  • 2019 American Transplant Congress

    Ex Vivo Normothermic Perfusion Of Discarded Human Kidneys Reveals Cold-storage-induced Renal Fibrinogen And Provides A Platform For Therapeutic Repair

    J. DiRito1, S. A. Hosgood2, M. Reschke3, M. L. Nicholson2, G. T. Tietjen4

    1Surgery, Yale University & University of Cambridge, New Haven, CT, 2Surgery, University of Cambridge, Cambridge, United Kingdom, 3Biomedical Engineering, Yale University, New Haven, CT, 4Surgery - Transplantation, Yale University, New Haven, CT

    *Purpose: The purpose of this study was to: 1) determine the cause of microvascular obstructions that arise during ex vivo normothermic perfusion (NMP) of human…
  • 2019 American Transplant Congress

    Racial Disparity in Pre-Kidney Transplant Work-Up

    J. Buggs1, H. Mohamed2, C. Myer3, S. Lloyd4, E. Rogers1, H. Pearson1, J. Clement1, D. Zunick1, A. Kumar2, V. Bowers1

    1Tampa General Hospital, Tampa, FL, 2University of South Florida, Tampa, FL, 3University of Tampa, Tampa, FL, 4University of Florida, Gainesville, FL

    *Purpose: The purpose of this study was to evaluate the disparity, by race, for pre-kidney transplant work-up completion rates of referred patients.*Methods: We conducted a…
  • 2019 American Transplant Congress

    RNA Sequencing Guided Identification of Shared mRNAs in Human Kidney Allograft Recipients with Acute T Cell Mediated Rejection or Active Antibody Mediated Rejection

    B. Dooley1, A. Verma2, R. Ding1, C. Li1, C. Snopkowski1, H. Yang1, B. Botticelli1, S. Albakry1, E. Edusei1, T. Muthukumar1, M. Lubetzky1, D. Dadhania1, J. Lee1, O. Elemento2, M. Suthanthiran1

    1Transplantation Medicine, Weill Cornell Medical College, New York, NY, 2Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY

    *Purpose: T cell help is essential for B cell production of antibodies to donor organ HLA. Because T cell-B cell interactions contribute to anti-allograft immunity,…
  • 2019 American Transplant Congress

    Expression of Prostaglandin E2 Receptors Track with Rejection in Porcine Kidney Transplants

    A. Harner1, Y. Wang2, X. Fang2, R. Lassiter1, T. D. Merchen1, S. Ho3, S. Nahman Jr2

    1Surgery, Augusta University, Augusta, GA, 2Nephrology, Augusta University, Augusta, GA, 3Gift of Life Michigan, Ann Arbor, MI

    *Purpose: Prostaglandin E2 (PGE2) is generated from arachidonic acid via cyclooxygenase-2 (COX2) and is known to modulate the immune response via its receptors: EP1, EP2,…
  • 2019 American Transplant Congress

    Comparison of Isolated Transplant Glomerulopathy with Chronic Antibody-Mediated Rejection in Regards to Endothelial-to-Mesenchymal Transition and Graft Survival

    B. H. Ozdemir1, F. N. Ozdemir2, G. Moray3, M. Haberal3

    1Pathology, Baskent University, Ankara, Turkey, 2Nephrology, Baskent University, Ankara, Turkey, 3Transplantation, Baskent University, Ankara, Turkey

    *Purpose: Transplant glomerulopathy (TG) has been proposed to be a component of chronic antibody-mediated rejection (CAMR). However, a substantial number of patients with TG do…
  • 2019 American Transplant Congress

    BCMA Expression by Alloreactive B Cells Increases during De Novo Alloantibody Responses

    N. Chai, G. Wu, I. Kim, A. Klein, S. Jordan

    Comprehensive Transplant Center, Cedars-Sinai Med Ctr, Los Angeles, CA

    *Purpose: BCMA(TNFRSF17) belongs to tumor necrosis factor receptor superfamily. It is selectively expressed during B/plasma cell differentiation while being nearly absent on naive and memory…
  • 2019 American Transplant Congress

    Comparison with Solid Organ Transplants Reveals Distinct Face Transplant Rejection Gene Signature That Reflects the Unique Immunobiology of Skin

    T. Win, B. Dyring-Andersen, R. Lopdrup, J. Teague, N. Murakami, A. Chandraker, S. G. Tullius, B. Pomahac, L. V. Riella, R. A. Clark

    Brigham and Women's Hospital, Boston, MA

    *Purpose: Skin containing transplants, such as face transplants, are immunologically unique. We compared the gene expression profiles of acute cellular rejection in human face transplants…
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