ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Integrated Analysis of Messenger RNA and Micro RNA Profiles in Fatty Liver Donors: Molecular Networks during Ischemia Reperfusion Injury

    D. Maluf1, A. Bajwa1, S. K. Satapathy2, V. Sai Bontha1, A. Kadimella1, J. Eason3, V. Mas4

    1UTHSC, Memphis, TN, 2UTHSC, memphis, TN, 3Director of Transplant Institute - UTHSC, Memphis, TN, 4Director of Transplant Research Institute, Memphis, TN

    *Purpose: Liver steatosis is a known risk factor for exacerbated ischemia-reperfusion injury (IRI) and poor outcomes after liver transplantation (LT). RNA profiling was performed to…
  • 2019 American Transplant Congress

    Urinary Cell mRNA Sequencing Profiles of Kidney Allograft Recipients Mirror Intragraft Events and Demonstrate Enrichment for Immune Cells

    M. Lubetzky1, A. Verma2, H. Yang1, T. Muthukumar1, S. Salvatore1, J. Lee1, D. Dadhania1, S. Seshan1, F. Mueller1, O. Elemento2, M. Suthanthiran1

    1Division of Nephrology, Weill Cornell, New York, NY, 2Institute for Computational Biomedicine, Weill Cornell, New York, NY

    *Purpose: Urinary cell mRNA profiling to interrogate kidney allograft status is based on the premise that the allograft can function as an in-vivo flow cytometer…
  • 2019 American Transplant Congress

    A Randomized, Controlled, Trial of Interventions to Promote Walking after Abdominal Organ Transplantation: The LIFT Study

    M. Serper1, I. Barankay2, S. Chadha1, J. Shults3, P. Reese1

    1University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 2Wharton School, University of Pennsylvania, Philadelphia, PA, 3Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA

    *Purpose: Substantial weight gain and sedentary behavior are common after transplantation. Behavioral economic strategies with financial incentives and reminders may promote healthy behaviors in the…
  • 2019 American Transplant Congress

    A National Survey of Immunosuppression Strategies in Intestinal Transplantation

    M. Segovia1, T. Beduschi2, J. Boike3, D. Farmer4, S. Horslen5, K. Iyer6, S. Jafri7, A. Langnas8, C. Matsumoto9, A. Mavis1, G. Mazariegos10, S. Nagai7, J. O'Leary11, Y. Patel1, D. Sudan1, N. Sulejmani7, B. Summers7, T. Schiano6

    1Duke, Durham, NC, 2Univ Miami, Miami, FL, 3NWU, Chicago, IL, 4UCLA, Los Angeles, CA, 5Seattle Child, Seattle, WA, 6Mt Sinai, NY, NY, 7Henry Ford, Detroit, MI, 8UNMC, Omaha, NE, 9Georgetown, Washington, DC, 10UPMC, Pittsburgh, PA, 11Dallas VAMC, Dallas, TX

    *Purpose: Review the management of immunosuppression (IS) for intestinal transplantation (IT) in the USA*Methods: A survey was created and sent via email to surgical directors…
  • 2019 American Transplant Congress

    Increasing Net Immunosuppression after BK Viremia

    L. Cotiguala, A. Masood, J. Park, A. Naik

    University of Michigan, Ann Arbor, MI

    *Purpose: BK viremia is associated with inferior kidney allograft outcomes. Typical treatment involves reduction in immunosuppression. However reduction in immunosuppression is also likely to lead…
  • 2019 American Transplant Congress

    Recipients with Model for End-Stage Liver Disease Sodium Score Driven by Renal Dysfunction Have Increased Post-Transplant Mortality

    T. Bittermann, D. Goldberg

    Gastroenterology, University of Pennsylvania, Philadelphia, PA

    *Purpose: Since the adoption of the Model for End-stage Liver Disease (MELD) score as a primary means of waitlist prioritization for liver transplantation (LT), an…
  • 2019 American Transplant Congress

    Elevated Visceral Adiposity is Associated with Post-Liver Transplant Mortality and Poorly Correlates with BMI in a Prospective Cohort Study

    R. Sharma, R. Rosenblatt, R. Knotts, J. Pisa, E. Verna

    Division of Liver Diseases and Transplantation, Columbia Univerisity Medical Center, New York, NY

    *Purpose: Obesity is increasingly common in end-stage-liver disease (ESLD). While obesity adversely affects outcomes, whether abnormalities in specific adipose tissue (AT) compartments lead to increased…
  • 2019 American Transplant Congress

    Early CXCR5+PD1+ICOS+ Circulating Follicular T Helpers Are Associated with De Novo Donor-Specific Anti-HLA Antibodies after Renal Transplantation

    R. Danger1, M. Chesneau1, F. Delbos2, S. Lebot1, C. Kerleau1, A. Chenouard1, A. Cesbron2, M. Giral3, S. Brouard3

    1CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France, 2Laboratoire Histocompatibilité et Immunogénétique - Etablissement Français du sang, Nantes, France, 3Centre d’Investigation Clinique en Biothérapie, Centre de ressources biologiques, Fondation Centaure, CRTI- INSERM UMR 1064- ITUN- Labex IGO -Université de Nantes -CHU Nantes, Nantes, France

    *Purpose: Donor specific anti-HLA antibodies (DSA) are a major risk factor associated with renal allograft outcome. As a trigger of B cell antibody production, T…
  • 2019 American Transplant Congress

    Total Parenteral Nutrition in Ex Vivo Lung Perfusion: Addressing Metabolism Improves Both Inflammation and Overall Graft Performance

    M. T. Buchko, S. Hatami, C. J. Stewart, S. Himmat, D. H. Freed, J. Nagendran

    Department of Surgery, Division of Cardiac Surgery, University of Alberta, Edmonton, AB, Canada

    *Purpose: Contemporary clinical ex vivo lung perfusion (EVLP) protocols generally limit metabolic supplementation to insulin and glucose. Furthermore, conventional perfusates are void of many ingredients…
  • 2019 American Transplant Congress

    Gender Disparity In Access To Liver Transplant Larger In White Than Black Patients

    K. Guo, J. Peipert, M. Abecassis, L. Zhao, D. Ladner

    Northwestern University, Chicago, IL

    *Purpose: Disparities in receipt of liver transplantation (LT) by gender and race have been documented, limiting access to this life saving treatment for particular patient…
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