2019 American Transplant Congress
Is Alemtuzumab Induction Safe In Septuagenarians Undergoing Deceased Donor Kidney Transplantation?
Wake Forest Baptist Medical Center, Winston-Salem, NC
*Purpose: Alemtuzumab induction in septuagenarians is controversial but understudied.*Methods: Single center retrospective review of adult deceased donor kidney transplant (KT) recipients receiving single dose (30…2019 American Transplant Congress
Promotion of Chimerism by Lymphohematopoietic Graft-versus-Host Responses in Patients Receiving Intestinal Transplantation
*Purpose: Long-term multilineage chimerism often appears in blood following intestinal transplantation (ITx), usually without graft-versus-host disease (GVHD). Patients with donor T cell macrochimerism (≥4%) in…2019 American Transplant Congress
Engineering Regulatory T Cells With TCR-Signaling-Responsive Interleukin 2 Nanoparticles Provides In Situ Suppression Of Alloimmunity
*Purpose: Adoptive cell transfer of regulatory T cells (TReg) has shown great potential in animal models of auto- and alloimmunity. The translation of TReg therapies…2019 American Transplant Congress
Development of a Pharmacy Collaborative Practice Agreement to Improve Efficiency and Management of Prescribing in a Renal Transplant Clinic
*Purpose: This study describes the development of a Collaborative Pharmacy Practice Agreement (CPPA) between transplant pharmacists and physicians and assesses change in prescription volume and…2019 American Transplant Congress
Three-Year Outcomes of Highly-Sensitized Kidney Transplant Recipients Desensitized with Imlifidase (IdeS)
1Cedars Sinai Medical Center, Los Angeles, CA, 2Hansa Medical, Lund, Sweden
*Purpose: The HLA-incompatible (HLAi) barrier has been traversed using desensitization therapies with IVIg, rituximab and/or plasmapheresis, although antibody-mediated rejection (ABMR) continues to be observed in…2019 American Transplant Congress
Effect of Chronic Kidney Disease on Allo-Immune Response in Mice
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). However, mouse models…2019 American Transplant Congress
Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy
*Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…2019 American Transplant Congress
Mechanical Irritation in Vascularized Tissue Allotransplantation Triggers Localized Skin Rejection
*Purpose: “Atypical” forms of skin rejection have been described in some hand transplanted patients mainly manifesting on the palm including dryness, scaling and thickening of…2019 American Transplant Congress
Immunosuppression after Organ Transplantation Does Not Enhance Patency of Cold-Stored Vein Allografts for Critical Limb Ischemia -Single Centre Experience
*Purpose: Sub-inguinal bypass with cold-stored saphenous vein allograft is a last option treatment for extensive peripheral arterial occlusive disease with absent autologous vein. The aim…
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