2019 American Transplant Congress
Elevated Visceral Adiposity is Associated with Post-Liver Transplant Mortality and Poorly Correlates with BMI in a Prospective Cohort Study
Division of Liver Diseases and Transplantation, Columbia Univerisity Medical Center, New York, NY
*Purpose: Obesity is increasingly common in end-stage-liver disease (ESLD). While obesity adversely affects outcomes, whether abnormalities in specific adipose tissue (AT) compartments lead to increased…2019 American Transplant Congress
Early CXCR5+PD1+ICOS+ Circulating Follicular T Helpers Are Associated with De Novo Donor-Specific Anti-HLA Antibodies after Renal Transplantation
*Purpose: Donor specific anti-HLA antibodies (DSA) are a major risk factor associated with renal allograft outcome. As a trigger of B cell antibody production, T…2019 American Transplant Congress
Total Parenteral Nutrition in Ex Vivo Lung Perfusion: Addressing Metabolism Improves Both Inflammation and Overall Graft Performance
Department of Surgery, Division of Cardiac Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Contemporary clinical ex vivo lung perfusion (EVLP) protocols generally limit metabolic supplementation to insulin and glucose. Furthermore, conventional perfusates are void of many ingredients…2019 American Transplant Congress
Gender Disparity In Access To Liver Transplant Larger In White Than Black Patients
Northwestern University, Chicago, IL
*Purpose: Disparities in receipt of liver transplantation (LT) by gender and race have been documented, limiting access to this life saving treatment for particular patient…2019 American Transplant Congress
Long Term Renal Function Following Islet Transplantation in the Clinical Islet Transplantation Consortium
*Purpose: Islet transplantation (IsletTp) is safe and effective treatment of Type 1 diabetes complicated by severe hypoglycemia (Diabetes Care 2016, 39:1230). But the requirement for…2019 American Transplant Congress
A Novel Ex Vivo Normothermic Perfusion Model of Human Antibody Mediated Rejection
*Purpose: Currently, no human experimental model of antibody-mediated rejection (AMR) exists, making the assessment of therapeutic interventions difficult hence the aim of our work is…2019 American Transplant Congress
Natural Anti-a Antibody Production In Mice Is Cd4 T Cell-independent
*Purpose: ABO-incompatible organ transplants (ABOi-Tx) are at high risk of rapid rejection mediated by preformed ABO antibodies (Ab) except during infancy when they are absent.…2019 American Transplant Congress
TACI Polymorphisms Associated with Increased Alloimmunity and Allograft Rejection
*Purpose: Transmembrane activator and CAML interactor (TACI) controls B cell differentiation. The TACI gene is highly polymorphic (>95% of all genes) and frequently variants exhibit…2019 American Transplant Congress
Desensitization Using Costimulatory Blockade and Bortezomib Does Not Prevent DSA Formation and Rejection in Reconstructive Transplantation
*Purpose: Sensitiziation in form of donor-specific antibodies (DSA) and subsequent antibody-mediated rejection (AMR) constitute some of the greatest risk factors for allograft rejection and long-term…2019 American Transplant Congress
Endothelial Cell Cytoskeleton Rearrangement (ECCSKR) and Endothelial to Mesenchymal Transition (EndoMT) in Liver Allografts Following Acute Rejection (AR): Its Significance on the Development of Liver Fibrosis (LF) and Graft Survival
1Pathology, Baskent University, Ankara, Turkey, 2Transplantation, Baskent University, Ankara, Turkey
*Purpose: Endothelial cell (EC) cytoskeleton is critical for EC adhesion and permeability. CSKR initiates permeability and influx of leukocytes which in turn leads to increased…
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