Am J Transplant, Volume 19, Suppl 3 Archives - Page 188 of 214 - ATC Abstracts

2019 American Transplant Congress
An Open-Label Proof-of-Principle Phase 2A Study to Evaluate Autologous Hematopoietic Stem Cell Transplantation for Allogeneic Organ Transplant Tolerance (ASCOTT)
A. Chruscinski¹, H. Atkins², A. Clement², D. Grant¹, C. Bredsen², E. Renner¹, J. Zhang¹, M. Epstein¹, L. Lilly¹, N. Selzner¹, O. Adeyi¹, R. Smith¹, S. Moshkelgosha¹, A. Humar¹, S. Juvet¹, G. Levy¹
¹Multi-Organ Transplantation, University Health Network, Toronto, ON, Canada, ²Ottawa Hospital Research Institute, Ottawa, ON, Canada
*Purpose: Long-term survival of recipients of solid organ transplants is hampered by chronic rejection, disease recurrence and immunosuppression-induced toxicity. Self-tolerance is re-established after autologous hematopoietic…
2019 American Transplant Congress
The Use of mTOR Inhibitors Prevents Acute Cellular Rejection in Kidney Transplantation on Belatacept Therapy
J. Shoji, J. C. Leung, Q. Tang, J. P. Roberts, F. Vincenti
University of California San Francisco, San Francisco, CA
*Purpose: Belatacept is a costimulatory blocker that is used as de novo maintenance immunosuppression in kidney transplantation to avoid toxic effects of calcineurin inhibitors and…
2019 American Transplant Congress
Recurrent Diabetic Nephropathy Despite Intensive Glycemic Control: An Observational Cohort Study
M. Coemans, E. Van Loon, E. Lerut, D. Kuypers, B. Sprangers, P. Gillard, C. Mathieu, G. Verbeke, M. Naesens
KU Leuven, Leuven, Belgium
*Purpose: After kidney transplantation, recurrence of diabetic nephropathy has been reported. The presentation and kinetics of recurrent diabetic nephropathy and its risk factors remain however…
2019 American Transplant Congress
Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates
H. Sweiss¹, J. Lyons¹, D. Ranch², K. Hitchman², E. Kincaide¹, B. Crowther¹
¹University Health System, The University of Texas at Austin, College of Pharmacy, Pharmacotherapy Division, Austin, TX, The University of Texas Health Science Center at San Antonio, San Antonio, TX, ²University Health System, The University of Texas Health Science Center at San Antonio, San Antonio, TX
*Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…
2019 American Transplant Congress
How and Why Dyrk1a is Required for Optimal Foxp3+ Treg Functions
W. W. Hancock, N. Zhou, R. Han, L. Wang
Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: TCR-induced calcineurin phosphatase activation and subsequent Nfat dephosphorylation, leading to Nfat translocation to the nucleus, is a key event in conventional T cell activation.…
2019 American Transplant Congress
Autoantibody Production Significantly Decreased with APRIL/BLyS Blockade in Murine Chronic Rejection Kidney Transplant Model
N. Bath, X. Ding, B. Verhoven, S. Reese, N. Wilson, A. Sukhwal, R. Redfield III
University of Wisconsin, Madison, WI
*Purpose: Chronic antibody mediated rejection (cAMR) remains a significant barrier to achieving long-term graft survival in kidney transplantation. Alloantibody production from B lymphocytes and plasma…
2019 American Transplant Congress
Technology Triggered Adherence Intervention – Preliminary Findings
T. E. Kaiser¹, N. S. Ejaz¹, S. Tremblay¹, N. J. Parrish², J. Benavides², B. Rehe², A. Govil¹, E. S. Woodle¹, R. R. Alloway¹
¹University of Cincinnati, Cincinnati, OH, ²UC Health, Cincinnati, OH
*Purpose: Medication non-adherence (M-NA) after renal transplant (RT) increases the risk of graft failure. We conducted a prospective, randomized, single center trial to evaluate 3…
2019 American Transplant Congress
Exogenous Erythropoietin Administration Promotes Murine Cardiac Allograft Survival via a Myeloid Cell-Dependent Mechanism
J. Horwitz, P. Cravedi, P. Heeger
Icahn School of Medicine at Mount Sinai, NY, NY
*Purpose: Erythropoietin (EPO) ligation of the EPO receptor (EPO-R) homodimer and EPO-R/CD131 heterodimer has protolerogenic effects on alloreactive T cell responses. While prior work, largely…
2019 American Transplant Congress
Hard-to-Place Kidney Offers: Through the Lens of the United Network for Organ Sharing Organ Center
S. M. Noreen, R. S. Brown, M. Lane, B. Wolford, C. A. Humphries
United Network for Organ Sharing, Richmond, VA
*Purpose: In 2016, the rate of deceased donor kidney discard continued to increase to 20%. It is well documented that multiple factors contribute to lower…
2019 American Transplant Congress
Routine Molecular Clostridioides difficile Screening and Overtreatment in Solid Organ Transplant Recipients
M. E. Newman¹, C. Oehler¹, M. Enriquez¹, E. Landon¹, C. T. Nguyen², N. N. Pettit², J. P. Ridgway¹, J. Pisano¹
¹Section of Infectious Disease, University of Chicago Medicine, Chicago, IL, ²Department of Pharmacy, University of Chicago Medicine, Chicago, IL
*Purpose: The objective of this analysis is to determine how frequently positive Clostridioides difficile (CD) screening tests, potentially identifying up to 20% of inpatients with…