Am J Transplant, Volume 19, Suppl 3 Archives - Page 185 of 214 - ATC Abstracts

2019 American Transplant Congress
Kidney Evaluation in Living Kidney Donors: Survey of US Transplant Centers 2018
N. Garg¹, K. L. Lentine², L. Inker³, A. X. Garg⁴, J. Rodrigue⁵, D. Segev⁶, D. A. Mandelbrot¹
¹UW Madison, Madison, WI, ²SLU, St. Louis, MO, ³Tufts, Boston, MA, ⁴Western University, London, ON, Canada, ⁵BIDMC, Boston, MA, ⁶JHU, Baltimore, MD
*Purpose: In recent years, a great deal of new data has emerged on outcomes after living donation. We surveyed US transplant centers to assess current…
2019 American Transplant Congress
Age-Related Effects on Thymic Output and Homeostatic T Cell Expansion Following Depletional Induction
H. Xu, H. Lee, A. Kirk
Surgery, Duke University, Durham, NC
*Purpose: Alemtuzumab induction leads to profound T cell depletion followed by a prolonged period of repopulation. Repopulation is thought to be influenced both by thymic…
2019 American Transplant Congress
Pre-Transplant Transcriptomic Signature in Peripheral Blood Predicts Early Acute Rejection after Kidney Transplant
W. Zhang¹, Z. Yi¹, C. Wei¹, K. Keung², Z. Sun¹, C. Xi¹, C. Woytovich¹, S. Farouk¹, L. Gallon³, M. Menon¹, C. Magee⁴, N. Najafian⁴, M. Samaniego⁵, A. Djamali⁶, S. Alexander², I. Rosales⁷, R. Smith⁷, P. O'Connell², R. Colvin⁷, P. Cravedi¹, B. Murphy¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²The University of Sydney, Sydney, Australia, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Henry Ford Hospital, Detroit, MI, ⁶University of Wisconsin, Madison, WI, ⁷Massachusetts General Hospital, Boston, MA
*Purpose: Early development of acute rejection after kidney transplantation is associated with diminished long-term graft survival. Predicting early acute rejection (EAR) at the time of…
2019 American Transplant Congress
Differences of Gut Microbiota Composition between Donor and Recipient May Predict 1-Year Graft Function
J. Kim¹, H. Cho², J. Park³, J. Jeong¹, M. Kwak⁴, B. Kim⁴, D. Kim¹, J. Lee⁵, B. Kim⁶, Y. Kim¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Chungbuk National University Hospital, Cheongju, Korea, Republic of, ³Kangwon National University Hospital, Seoul, Korea, Republic of, ⁴Chunlab Inc., Seoul, Korea, Republic of, ⁵Seoul National University Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Signals derived from gut microbiota are critical for the development and maintenance of the human immune system. In view of kidney transplantation (KT), allograft…
2019 American Transplant Congress
Using an Electronic Medical Record Tool to Document Transplant Option Discussions among Patients with EGFR ≤ 20 mL/min/1.73m²
A. Yishak¹, R. R. Brentari², R. M. Love La Londe³, E. Clark⁴, E. Clark⁴, J. Sun⁵, S. Vupputuri⁶
¹Nephrology, MAPMG, Mc Lean, VA, ²KP National Transplant Service, Oakland, CA, ³KP National Transplant Services, Oakland, CA, ⁴KP National Transplant Services, silver spring, MD, ⁵KP, Rockville, MD, ⁶MAPRI, MAPMG, Rockville, MD
*Purpose: The purpose of this study, in a large integrated health system, was to improve: 1) the documentation of transplant option discussions by providers among…
2019 American Transplant Congress
CNI-Free Therapy with Iscalimab (anti-CD40 mAb) Preserves Allograft Histology Compared to Standard of Care after Kidney Transplantation
E. Farkash¹, A. Naik¹, H. Tedesco-Silva², B. Nashan³, O. Witzke⁴, M. van den Hoogen⁵, S. Berger⁶, D. M. Cibrik⁷, S. Mulgaonkar⁸, D. B. Leeser⁹, R. Alloway¹⁰, A. Patel¹¹, J. Pratchke¹², C. Sommerer¹³, A. Wiseman¹⁴, A. Van Zuilen¹⁵, U. Laessing¹⁶, J. Rush¹⁶, B. Haraldsson¹⁶
¹Univ of Michigan, Ann Arbor, MI, ²Hospital do Rim, São Paulo, Brazil, ³Univ. Hamburg, Hamburg, Germany, ⁴Univ Essen, Essen, Germany, ⁵Erasmus MC, Rotterdam, Netherlands, ⁶UMC Groningen, Gröningen, Netherlands, ⁷Univ of Kansas, Kansas City, KS, ⁸Saint Barnabas MC, Livingston, NJ, ⁹East Carolina Univ, Greenville, NC, ¹⁰Univ of Cincinnati, Cincinnati, OH, ¹¹Henry Ford Hosp, Detroit, MI, ¹²Charité Univ, Berlin, Germany, ¹³Univ Heidelberg, Heidelberg, Germany, ¹⁴Univ of Colorado SM, Denver, CO, ¹⁵Univ MC, Utrecht, Netherlands, ¹⁶Novartis, Basel, Switzerland
*Purpose: To assess if calcineurin (CNI)-free therapy with iscalimab preserves the quality of transplanted kidney grafts.*Methods: Iscalimab (CFZ533) is a new, fully human, Fc-silenced, non-depleting,…
2019 American Transplant Congress
Multiplexed Droplet Single-Cell RNA-Sequencing for Cellular Profiling of Transplant Rejection
A. Schroeder, T. Sigdel, I. Damm, S. Sur, G. Hartoularos, J. Ye, M. Sarwal
Department of Surgery, UCSF, San Francisco, CA
*Purpose: Multiplexed droplet single-cell RNA-sequencing (mdscRNA-seq) has been utilized across many tissue types for fast and paralleled transcriptomic profiling. However, maintaining sample identity for differential…
2019 American Transplant Congress
Gut Microbiome And Acute Rejection After Kidney Transplantation
H. Cho¹, Y. Yang¹, J. Kim², J. Moon², J. Jeong², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, Y. Kim², H. Lee²
¹Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc., Seoul, Korea, Republic of, ⁵Internal Medicine, Seoul National University, Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Acute rejection (AR) is a common complication in kidney transplantation (KT) and associated with reduced patient-graft survival. Recent studies have shown that the gut…
2019 American Transplant Congress
Iguratimod Attenuates the Production of Donor Specific Antibody by Inducing CD19⁺Tim-1⁺ Regulatory B Cells and Imbalance of Th17 Treg
Z. Wang, S. Fei, H. Chen, Z. Han, L. Sun, J. Tao, X. Ju, M. Zheng, R. Tan, M. Gu
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: This study was designed to investigate the effect and mechanisms of Iguratimod on circulating DSA and allograft survival in a skin transplant model.*Methods: Mice…
2019 American Transplant Congress
Characterization of Innate Lymphoid Cells in Full Facial and Limb Transplant Recipients
T. J. Borges¹, J. T. O’Malley², B. Kollar³, B. Pomahac³, S. G. Talbot³, L. V. Riella¹
¹Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ²Department of Dermatology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Plastic Surgery, Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: Vascular composite allotransplantation (VCA) transplantation is a life-transforming procedure with encouraging results. Despite the recent advances, the immunological response in these patients is still…