Am J Transplant, Volume 19, Suppl 3 Archives - Page 178 of 214 - ATC Abstracts

2019 American Transplant Congress
The Impact of Sleeve Gastrectomy Following Liver Transplant in Patients with Non-Alcoholic Steatosis: A Five-Year Experience
M. C. Morris¹, A. D. Jung¹, Y. Kim¹, V. K. Dhar¹, S. Shah¹, D. Schauer², E. Smith², T. Diwan¹
¹Surgery, University of Cincinnati, Cincinnati, OH, ²Medicine, University of Cincinnati, Cincinnati, OH
*Purpose: Non-alcoholic steatohepatitis (NASH) cirrhosis is an increasingly common indication for liver transplantation (LT) in the United States and obese patients continue to be at…
2019 American Transplant Congress
The Effect of Kidney Transplantation on Neurocognitive Function: A Prospective Study
B. P. Concepcion, J. C. Jackson, A. Kiehl, R. Adu-Boahene, E. Collar, M. Reed, M. Sika, J. Van, R. C. Forbes
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The effect of kidney transplantation on global cognition and executive function in patients with advanced kidney disease is unknown.*Methods: We prospectively enrolled patients scheduled…
2019 American Transplant Congress
Granulocyte – Colony Stimulating Factor (G-CSF) and Granulocyte – Macrophage Colony Stimulating Factor (GM-CSF) Administration Augments the Incidence of Peripheral Blood Suppressive Regulatory T Cells in Nonhuman Primates
K. Sasaki, Y. Wang, L. Lu, J. Hughs, A. W. Thomson, M. B. Ezzelarab
Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
*Purpose: Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage CSF (GM-CSF) are known to mobilize immune cells to the peripheral blood. We evaluated regulatory T cells (Treg)…
2019 American Transplant Congress
Glycogen Synthase Kinase 3alpha Serine 21 Phosphorylation Inhibits Hepatocyte Autophagy to Facilitate Liver Ischemia Reperfusion Injury
M. Ni¹, H. Zhou², R. Busuttil¹, J. Kupiec-Weglinski¹, X. Wang², Y. Zhai¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Glycogen synthase kinase 3 (Gsk3) has α and β isoforms. They are constitutively active in cells and inhibited upon stimulations by N-terminal serine phosphorylation.…
2019 American Transplant Congress
TDCA/Valine Reverse Obesity and Ameliorate Alloimmune Responses through a Decreased Hypothalamic Expression of MCH
A. ElKhal¹, M. Markus Quante¹, T. Heinbokel¹, Y. Nian¹, K. Minami¹, R. Maenosono¹, J. Iske¹, B. Desai², A. Banks², E. Maratos-Flier², A. Elkhal¹, S. G. Tullius¹
¹Brigham and Women's Hospital, Boston, AL, ²Beth Israel Deaconess Medical Center, Boston, AL
*Purpose: Obesity is associated with low grade inflammation and bariatric surgery is the only effective treatment in reducing excess weight both pre- and post-transplant.*Methods: Here,…
2019 American Transplant Congress
The Evolving Clinical Presentation of Acute Rejection in Face Transplantation
V. Haug, B. Kollar, D. Obed, H. Kiwanuka, M. Turk, L. Wo, S. Tasigiorgos, M. Kueckelhaus, L. Riella, B. Pomahac
Plastic and Reconstructive Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Clinical signs such as erythema or edema are traditionally helpful to diagnose Acute rejection (AR) in face transplantation (FT) in the early follow-up. The…
2019 American Transplant Congress
Cardiovascular Mortality in Transplant Patients; A Population-Based Cohort Study 1988-2013 in Australia and New Zealand
M. Wyld¹, N. De La Mata², P. Masson³, E. O'Lone², A. Webster²
¹Renal Department, Royal Prince Alfred Hospital, Camperdown, Australia, ²School of Public Health, University of Sydney, Sydney, Australia, ³Renal Department, Royal Free London NHS Foundation Trust, London, United Kingdom
*Purpose: Transplant recipients experience excess cardiovascular morbidity and mortality. We compared cardiovascular death rates in kidney transplant recipients to the general population and identified risk…
2019 American Transplant Congress
Expanding the Donor Pool with Extended Criteria DCD Livers
P. Mihaylov¹, B. Ekser², R. Mangus², J. Fridell², D. Soma², C. Kubal²
¹Indiana Univ School of Medicine, Pavia Univ School of Medicine, Indianapolis, IN, ²Indiana Univ School of Medicine, Indianapolis, IN
*Purpose: Utilization of extended criteria donation after circulatory death (ECD DCD) livers has remained cautious due to potentially worse outcomes because of higher rates of…
2019 American Transplant Congress
High Numbers of Differentiated CD8⁺CD28^– T Cells Are Associated with a Substantially Lowered Risk for Late Rejection and Graft Loss after Kidney Transplantation
M. G. Betjes, A. Langerak, M. Klepper, N. Litjens
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Recipients of a kidney transplant have a prematurely aged T-cell system. This is reflected in lowered thymic output, reduced telomere length and more highly…
2019 American Transplant Congress
Treg And Bone Marrow Infusion Promotes Survival Of Donor Kidney Grafted Months After Disappearance Of Mixed Chimerism
K. Bruestle, P. Alonso-Guallart, E. Lopes, G. Pierre, N. Llore, H. Sakai, S. Kofman, D. Ekanayake-Alper, M. Sykes, A. Griesemer
Columbia Center for Translational Immunology, Columbia University, New York City, NY
*Purpose: Transient mixed chimerism induced with non-myeloablative conditioning in monkeys and humans induces tolerance to about 70% of donor kidney grafts transplanted at the time…