Am J Transplant, Volume 19, Suppl 3 Archives - Page 174 of 214 - ATC Abstracts

2019 American Transplant Congress
mTORC2 Restricts mTORC1 Metabolic Function in Dendritic Cells to Limit Their Allostimulatory Activity
H. Dai¹, A. Watson¹, A. Menk², D. Stolz³, G. Delgoffe², A. Thomson¹
¹Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ²Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, ³Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Mechanistic target of rapamycin complex 2 (TORC2) deficiency in conventional dendritic cells (DC) results in their enhanced pro-inflammatory and T cell allostimulatory activity; however,…
2019 American Transplant Congress
Interruption of Notch Signaling via Blockade of Delta-Like Ligands 1 and 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
A. Matar, Y. Dong, B. Lovasik, D. Mathews, A. Ghosh, C. Breeden, A. Stephenson, W. Kitchens, A. Adams
Surgery and Transplantation, Emory University, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
2019 American Transplant Congress
Recipient Antibiotics Pretreatment Protects Liver Transplants from Ischemia-Reperfusion Injury via Prostaglandin E2: From Bench-to Bedside
K. Nakamura, S. Kageyama, T. Ito, H. Hirao, K. Kadono, K. J. Dery, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation and autophagy enhancement to mitigate ischemia-reperfusion injury (IRI) in orthotopic liver…
2019 American Transplant Congress
What Are You Smoking? The Impact of Donor Drug Use on Long Term Survival Post-Transplant
D. A. Baran¹, A. Long¹, J. T. Lansinger², H. Copeland³, J. M. Herre¹, W. Old¹, G. Zeevi¹, C. Barreiro¹, C. Kemp¹, B. H. Smith¹, K. Stelling¹, A. Ingemi¹, P. Bourassa¹, J. Philpott¹
¹Sentara Heart Hospital, Norfolk, VA, ²Eastern Virginia Medical School, Norfolk, VA, ³Division of Cardiothoracic Surgery, University of Mississippi Medical Center, Jackson, MS
*Purpose: Drug use is a common aspect in the history of heart transplant donors. Whether prior or current drug use is associated with inferior post…
2019 American Transplant Congress
Four-Year Follow Up of Kidney Transplantation Using Alemtuzumab Induction and Belatacept/Sirolimus Maintenance Therapy
A. Kirk¹, H. Xu¹, A. Ghali², A. Mehta², A. Guasch²
¹Surgery, Duke University, Durham, NC, ²Transplant Center, Emory University, Atlanta, GA
*Purpose: Kidney transplantation remains limited by the chronic toxicities associated with calcineurin inhibitors (CNIs) and steroids. The objective of this clinical trial was to determine…
2019 American Transplant Congress
A CMV Vaccine Based on Non-Replicating Lymphocytic Choriomeningitis Virus Vectors Expressing gB and pp65 is Safe and Immunogenic in Healthy Volunteers and Entering a Phase 2 Trial in Kidney Transplant Recipients
C. N. Kotton¹, M. Schwendinger², G. Thiry³, B. De Vos⁴, F. De Boever⁵, G. Leroux-Roels⁶, A. Lilja⁷
¹Infectious Diseases Division, Boston, MA, ²Hookipa Biotech AG, Vienna, Austria, ³Hookipa Biotech GmbH, VIenna, Austria, ⁴Bejamad sprl/bvba, Beersel, Belgium, ⁵Centrum voor vaccinologie (CEVAC), Gdent, Belgium, ⁶Centrum voor vaccinologie (CEVAC), Gent, Belgium, ⁷Hookipa Biotech GmbH, Vienna, Austria
*Purpose: Cytomegalovirus (CMV) is a significant pathogen in pregnancy and immunocompromised patients. Antiviral prophylaxis is limited by toxicities, recurrent infection, and resistance. A safe and…
2019 American Transplant Congress
Standardizing Blood Pressure Measurement across 17 Pediatric Transplant Centers: The Improving Renal Outcomes Collaborative
M. E. Seifert¹, R. Garro², R. P. George², G. Barletta³, C. W. Belsha⁴, A. Chaudhuri⁵, J. W. Goebel⁶, L. Wickman⁷, D. Matossian⁸, J. Misurac⁹, C. Nailescu¹⁰, C. R. Nguyen¹¹, M. Pearl¹², A. Pollack¹³, C. S. Pruette¹⁴, P. Singer¹⁵, P. S. Verghese¹⁶, B. A. Warady¹⁷, D. S. Dahale¹⁸, D. K. Hooper¹⁸
¹University of Alabama, Birmingham, AL, ²Emory University, Atlanta, GA, ³Phoenix Children's Hospital, Phoenix, AZ, ⁴Saint Louis University, St. Louis, MO, ⁵Stanford University, Stanford, CA, ⁶Children's Hospital Colorado, Aurora, CO, ⁷Michigan Medicine, Ann Arbor, MI, ⁸Lurie Children's Hospital, Chicago, IL, ⁹University of Iowa, Iowa City, IA, ¹⁰Riley Hospital For Children, Indianapolis, IN, ¹¹Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ¹²UCLA Mattel Children’s Hospital, Los Angeles, CA, ¹³Seattle Children's Hospital, Seattle, WA, ¹⁴Johns Hopkins University, Baltimore, MD, ¹⁵Cohen Children's Medical Center, New Hyde Park, NY, ¹⁶University of Minnesota, Minneapolis, MN, ¹⁷Children's Mercy Kansas City, Kansas City, MO, ¹⁸Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: We report efforts from the Improving Renal Outcomes Collaborative (IROC) to standardize appropriate BP measurement across 17 pediatric kidney transplant centers.*Methods: 17 centers participated…
2019 American Transplant Congress
Advanced Immunological T-cell Ageing Defined by a Very Low Thymic Function Identifies Patients with a Substantial Increased Risk for Long-Term Mortality after Kidney Transplantation
M. G. Betjes, A. Langerak, M. Klepper, N. Litjens
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: End-stage renal disease is associated with premature ageing of the T-cell immune system. At the time of kidney transplantation the average biological age of…
2019 American Transplant Congress
A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy
J. Zuber¹, O. Boyer¹, B. Neven¹, R. Berthaud¹, M. Ould Rabah¹, I. Jollet², V. Renac², F. Pirenne², S. Gross², R. Djoudi², P. Tiberghien², J. Taupin³, S. Blanche¹, R. Salomon¹
¹Paris Descartes University, Paris, France, ²Etablissement Français du Sang, Paris, France, ³Department of Immunology and Histocompatibility, St Louis Hospital, Paris, France
*Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…
2019 American Transplant Congress
Impact of Liver Recipient Genotype on Tacrolimus
S. Tremblay¹, T. Fukuda², T. Mizuno², A. A. Vinks², E. Woodle¹, J. Klawitter³, J. Klawitter³, U. Christians³, R. R. Alloway¹
¹University of Cincinnati, Cincinnati, OH, ²Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ³iC42 Clinical Research and Development, Aurora, CO
*Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…