Am J Transplant, Volume 19, Suppl 3 Archives - Page 174 of 214 - ATC Abstracts

2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
Y. Huang, H. Xu, Y. Wen, S. Ildstad
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
M. Ma, P. Chhabra, K. Brayman
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
2019 American Transplant Congress
Mortality and Morbidity in Kidney Transplant Recipients with a Failing Graft
N. N. Lam¹, D. J. Boyne², R. R. Quinn², P. C. Austin³, B. R. Hemmelgarn², P. Campbell¹, G. A. Knoll⁴, L. Tibbles², S. Yilmaz², H. Quan², P. Ravani²
¹University of Alberta, Edmonton, AB, Canada, ²University of Calgary, Calgary, AB, Canada, ³ICES, Toronto, ON, Canada, ⁴University of Ottawa, Ottawa, ON, Canada
*Purpose: Due to their history of renal disease and exposure to immunosuppression, kidney transplant recipients with a failing graft may be at higher risk of…
2019 American Transplant Congress
Did COIIN Cohort A Maintain Graft Survival Performance While Increasing Moderate to High KDPI Transplants?
J. Foutz, R. J. Carrico, K. Sisaithong, H. Tosoc-Haskell, D. Klassen
Research, United Network for Organ Sharing, Richmond, VA
*Purpose: The Collaborative Innovation and Improvement Network (COIIN) was a 3-year OPTN project aimed at increasing the utilization of kidneys with a kidney donor profile…
2019 American Transplant Congress
The Safety of Surveillance and Indication Biopsies in Kidney Transplantation: A Series of 2000 Biopsies
A. S. Naik¹, Y. Huang², D. M. Cibrik³, E. Shaban¹, M. McGuire¹, C. Boyer¹, S. P. Norman¹
¹Internal Medicine/Nephrology, Univ of Michigan Medical Ctr, Ann Arbor, MI, ²Internal Medicine/Nephrology, Univ of California Davis, Sacremento, CA, ³Internal Medicine/Nephrology, Kansas University Medical Center, Kansas City, KS
*Purpose: Kidney biopsy (KB) remains the most important diagnostic tool in kidney transplantation. Despite its value, surveillance KB are not routinely done at majority of…
2019 American Transplant Congress
NK Cells Are Associated with Alloimmune Failure in Transplanted Children
E. T. Chambers¹, O. Martinez², M. Robien³, C. Chan¹, R. Ettenger⁴, P. Grimm⁵, H. Lee¹, E. Reed⁴, L. Stempora⁶, M. Sarwal⁷, B. Warshaw⁸, C. Zhao¹, A. D. Kirk⁶
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Stanford, Palo Alto, CA, ³NIH, Bethesda, MD, ⁴Pediatrics, UCLA, Los Angeles, CA, ⁵Pediatrics, Stanford, Stanford, CA, ⁶Surgery, Duke University, Durham, NC, ⁷Pediatrics, UCSF, San Francisco, CA, ⁸Pediatrics, Emory University, Atlanta, GA
*Purpose: Alloimmune failure, defined as the development of donor specific antibody (DSA) and/ or allograft rejection, remains a significant complication in pediatric kidney transplantation. NK…
2019 American Transplant Congress
Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity and Accelerate Allograft Vascular Remodeling
F. Migneault¹, M. Dieudé¹, J. Turgeon¹, A. Karakeussian Rimbaud¹, D. Beillevaire¹, M. Hardy², A. Brodeur¹, N. Thibodeau¹, C. Perreault², M. Hébert¹
¹CRCHUM, Montreal, QC, Canada, ²IRIC, Montreal, QC, Canada
*Purpose: Acute vascular rejection of allografts is associated with endothelial apoptosis which in turn contributes to the development of transplant vasculopathy. We previously showed that…
2019 American Transplant Congress
Preliminary Mechanistic Studies of Regulatory Dendritic Cell (DCreg) Cell Infusion in Living Donor Liver Transplant Recipients
A. Thomson, C. Macedo, A. Zahorchak, H. Dai, A. Humar, F. G. Lakkis, M. Styn, D. Metes
Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: This is a first-in-human phase I/II safety and preliminary efficacy trial of donor-derived regulatory dendritic cells (DCreg) in living donor liver transplantation (LTx) in…
2019 American Transplant Congress
Efficacy and Safety Outcomes with De Novo Use of Everolimus-Based Regimen in Renal Transplant Recipients with Delayed Graft Function from the TRANSFORM Study
S. Chadban¹, F. Oppenheimer¹, F. Citterio¹, O. Witzke¹, V. D. Garcia¹, A. Gutierrez-Dalmau¹, P. Narvekar², M. P. Hernandez Gutierrez², P. Bernhardt², A. Wiseman¹
¹TRANSFORM Study Group, Basel, Switzerland, ²Novartis Pharma AG, Basel, Switzerland
*Purpose: To evaluate the effect of everolimus with reduced CNI (EVR+rCNI) vs mycophenolic acid with standard CNI (MPA+sCNI) on efficacy and safety outcomes in RTxR…
2019 American Transplant Congress
Long-Term Outcomes in Patients with Obesity and Renal Disease after Sleeve Gastrectomy
A. Kassam, A. Mirza, Y. Kim, E. S. Woodle, S. A. Shah, M. C. Cuffy, R. C. Quillin III, L. Sage Silski, A. Govil, M. Cardi, T. S. Diwan
Department of Surgery, University of Cincinnati, Cincinnati, OH
*Purpose: Morbid obesity is a barrier to kidney transplantation in patients with end-stage renal disease (ESRD) and is associated with progression of chronic kidney disease…