Am J Transplant, Volume 19, Suppl 3 Archives - Page 171 of 214 - ATC Abstracts

2019 American Transplant Congress
Erk-elk1-mir-711 Signalling In Cardiac Ischemia Reperfusion Injury In Heart Transplantation
H. Zheng, Y. Su, C. Zhu, V. Veramkovich, X. Zheng
Pathology, University of Western Ontario, London, ON, Canada
*Purpose: This study aims to discover new molecular mechanisms involved in and to develop new treatment for preventing ischemia reperfusion injury in heart transplantation.*Methods: The…
2019 American Transplant Congress
Stabilization of Cell Junctions Ameliorates the Effects of Brain Death Induced Acute Lung Injury Post-Transplantation
D. P. Allen¹, Z. Tu¹, C. Wallace¹, C. Li¹, J. Kilkenny¹, K. J. Patel¹, D. Nord², S. N. Nadig¹, C. Atkinson²
¹Surgery, Medical University of South Carolina, CHARLESTON, SC, ²Microbiology & Immunology, Medical University of South Carolina, CHARLESTON, SC
*Purpose: Donor Brain death (BD) induces acute lung injury (BD-ALI), characterized by the breakdown of endo/epithelial barrier functions. These injuries are further exacerbated by ischemia…
2019 American Transplant Congress
A Robust and Portable Protocol for RNA Isolation from Urinary Cells for Noninvasive Monitoring of Kidney Allograft Recipients
B. Botticelli, S. Albakry, E. Edusei, H. Yang, M. Cassidy, C. Li, C. Snopkowski, M. Lubetzky, J. Lee, D. Dadhania, T. Muthukumar, M. Suthanthiran
Weill Cornell, New York, NY
*Purpose: Urinary cell mRNA abundance, assessed by RT-qPCR assay, is a robust monitoring tool. In the CTOT-04 study, urine processed by 5 transplant sites were…
2019 American Transplant Congress
Development of De Novo DSA after Kidney Transplant Correlates with Low Quantity of Peripheral Blood “Antibody-Suppressor” CD8⁺T Cells
J. Zimmerer¹, M. Basinger¹, B. Ringwald¹, R. Pelletier¹, A. Rajab¹, A. El-Hinnawi¹, M. Abdel-Rousoul², H. Parekh³, K. Washburn¹, G. Bumgardner¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH, ³Clinical Histocompatibility Laboratory, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: It is well known that CD4+ T cells provide “help” for antibody production in vivo. Our group discovered a novel subset of murine antibody-suppressor…
2019 American Transplant Congress
Pre-Treatment Lymphocyte Status in HCC Patients Associates with DEB-TACE Response and Correlates with Increased Regulatory Immune Cells
K. Nunez¹, T. Sandow², S. Robertson¹, P. Thevenot¹, A. Cohen¹
¹Ochsner Health System, New Orleans, LA, ²Interventional Radiology, Ochsner Health System, New Orleans, LA
*Purpose: Hepatocellular carcinoma (HCC) recurrence after transplantation is associated with higher tumor grade on explant, failure to respond to DEB-TACE, and pretreatment lymphopenia. We prospectively…
2019 American Transplant Congress
Subclinical Antibody Mediation Rejection in Stable Kidney Recipients with De Novo Donor Specific Antibodies and Correlation with Donor Derived Cell Free DNA Testing
A. P. Bregman, E. J. Stites, J. Gralla, A. Wiseman, J. E. Cooper
Kidney and Pancreas Transplant, University of Colorado-Denver, Aurora, CO
*Purpose: Subclinical antibody mediated rejection (sAMR) is associated with inferior graft outcomes but its diagnosis relies on the presence of biomarkers as well as histology.…
2019 American Transplant Congress
3-year Outcome Of Heart Transplantation In Patients With Amyloidosis
J. Patel, M. Kittleson, D. H. Chang, R. Levine, S. Dimbil, L. Czer, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Both amyloid light chain (AL) amyloidosis and transthyretin-related (TTR) amyloid are expanding indications for heart transplantation (HTx). In the past, AL amyloid, in particular,…
2019 American Transplant Congress
Slowed Progression of Maximal Intimal Thickening by Intravascular Ultrasound after Initiation of Sirolimus
A. Putschoegl¹, K. Campbell¹, M. Everitt¹, S. Miyamoto¹, B. Pietra², S. Auerbach¹
¹Children's Hospital Colorado, Aurora, CO, ²University of Florida Health, Gainesville, FL
*Purpose: Evidence in adult heart transplant (HT) patients (pt) shows that initiating sirolimus (SRL) slows progression of cardiac allograft vasculopathy (CAV) measured by intravascular ultrasound…
2019 American Transplant Congress
Impact of Donor Acute Kidney Injury on GFR at 1 Year
R. Heilman, A. Kumar, A. Srinivasan, M. Smith, J. Huskey, H. Khamash, A. Mathur, C. Jadlowiec, A. Moss, K. S. Reddy
Mayo Clinic, Phoenix, AZ
*Purpose: GFR 1-year after kidney transplantation is a marker for long term graft survival. The aim of this study is to determine the impact of…
2019 American Transplant Congress
Racial Differences in Acute Kidney Injury Occurrence among Deceased Kidney Donors
M. Doshi¹, I. Hall², S. Mohan³, C. Liu⁴, H. Philbrook⁴, P. Reese⁵, S. Mansour⁶, F. Weng⁷, E. Akalin⁸, J. Bromberg⁹, M. Harhay¹⁰, T. Muthukumar¹¹, B. Schroeppel¹², P. Singh¹³, C. Parikh⁴
¹University of Michigan, Ann Arbor, MI, ²University of Utah, Salt Lake City, UT, ³Columbia, New York, NY, ⁴Johns Hopkins, Baltimore, MD, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Yale University, New Haven, CT, ⁷St. Barnabas, Livingston, NJ, ⁸Mount Sinai, New York, NY, ⁹University of Maryland, Baltimore, MD, ¹⁰Drexel, Philadelphia, PA, ¹¹Cornell, New York, NY, ¹²University of Ulm, Ulm, Germany, ¹³Jefferson, Philadelphia, PA
*Purpose: Kidneys from African American (AA) deceased donors have lower graft survival than kidneys from white donors, regardless of recipient race. We hypothesized that kidneys…