Am J Transplant, Volume 19, Suppl 3 Archives - Page 16 of 214 - ATC Abstracts

2019 American Transplant Congress
Recipient Antibiotics Pretreatment Protects Liver Transplants from Ischemia-Reperfusion Injury via Prostaglandin E2: From Bench-to Bedside
K. Nakamura, S. Kageyama, T. Ito, H. Hirao, K. Kadono, K. J. Dery, J. Aziz, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation and autophagy enhancement to mitigate ischemia-reperfusion injury (IRI) in orthotopic liver…
2019 American Transplant Congress
What Are You Smoking? The Impact of Donor Drug Use on Long Term Survival Post-Transplant
D. A. Baran¹, A. Long¹, J. T. Lansinger², H. Copeland³, J. M. Herre¹, W. Old¹, G. Zeevi¹, C. Barreiro¹, C. Kemp¹, B. H. Smith¹, K. Stelling¹, A. Ingemi¹, P. Bourassa¹, J. Philpott¹
¹Sentara Heart Hospital, Norfolk, VA, ²Eastern Virginia Medical School, Norfolk, VA, ³Division of Cardiothoracic Surgery, University of Mississippi Medical Center, Jackson, MS
*Purpose: Drug use is a common aspect in the history of heart transplant donors. Whether prior or current drug use is associated with inferior post…
2019 American Transplant Congress
Four-Year Follow Up of Kidney Transplantation Using Alemtuzumab Induction and Belatacept/Sirolimus Maintenance Therapy
A. Kirk¹, H. Xu¹, A. Ghali², A. Mehta², A. Guasch²
¹Surgery, Duke University, Durham, NC, ²Transplant Center, Emory University, Atlanta, GA
*Purpose: Kidney transplantation remains limited by the chronic toxicities associated with calcineurin inhibitors (CNIs) and steroids. The objective of this clinical trial was to determine…
2019 American Transplant Congress
A CMV Vaccine Based on Non-Replicating Lymphocytic Choriomeningitis Virus Vectors Expressing gB and pp65 is Safe and Immunogenic in Healthy Volunteers and Entering a Phase 2 Trial in Kidney Transplant Recipients
C. N. Kotton¹, M. Schwendinger², G. Thiry³, B. De Vos⁴, F. De Boever⁵, G. Leroux-Roels⁶, A. Lilja⁷
¹Infectious Diseases Division, Boston, MA, ²Hookipa Biotech AG, Vienna, Austria, ³Hookipa Biotech GmbH, VIenna, Austria, ⁴Bejamad sprl/bvba, Beersel, Belgium, ⁵Centrum voor vaccinologie (CEVAC), Gdent, Belgium, ⁶Centrum voor vaccinologie (CEVAC), Gent, Belgium, ⁷Hookipa Biotech GmbH, Vienna, Austria
*Purpose: Cytomegalovirus (CMV) is a significant pathogen in pregnancy and immunocompromised patients. Antiviral prophylaxis is limited by toxicities, recurrent infection, and resistance. A safe and…
2019 American Transplant Congress
Standardizing Blood Pressure Measurement across 17 Pediatric Transplant Centers: The Improving Renal Outcomes Collaborative
M. E. Seifert¹, R. Garro², R. P. George², G. Barletta³, C. W. Belsha⁴, A. Chaudhuri⁵, J. W. Goebel⁶, L. Wickman⁷, D. Matossian⁸, J. Misurac⁹, C. Nailescu¹⁰, C. R. Nguyen¹¹, M. Pearl¹², A. Pollack¹³, C. S. Pruette¹⁴, P. Singer¹⁵, P. S. Verghese¹⁶, B. A. Warady¹⁷, D. S. Dahale¹⁸, D. K. Hooper¹⁸
¹University of Alabama, Birmingham, AL, ²Emory University, Atlanta, GA, ³Phoenix Children's Hospital, Phoenix, AZ, ⁴Saint Louis University, St. Louis, MO, ⁵Stanford University, Stanford, CA, ⁶Children's Hospital Colorado, Aurora, CO, ⁷Michigan Medicine, Ann Arbor, MI, ⁸Lurie Children's Hospital, Chicago, IL, ⁹University of Iowa, Iowa City, IA, ¹⁰Riley Hospital For Children, Indianapolis, IN, ¹¹Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ¹²UCLA Mattel Children’s Hospital, Los Angeles, CA, ¹³Seattle Children's Hospital, Seattle, WA, ¹⁴Johns Hopkins University, Baltimore, MD, ¹⁵Cohen Children's Medical Center, New Hyde Park, NY, ¹⁶University of Minnesota, Minneapolis, MN, ¹⁷Children's Mercy Kansas City, Kansas City, MO, ¹⁸Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: We report efforts from the Improving Renal Outcomes Collaborative (IROC) to standardize appropriate BP measurement across 17 pediatric kidney transplant centers.*Methods: 17 centers participated…
2019 American Transplant Congress
Advanced Immunological T-cell Ageing Defined by a Very Low Thymic Function Identifies Patients with a Substantial Increased Risk for Long-Term Mortality after Kidney Transplantation
M. G. Betjes, A. Langerak, M. Klepper, N. Litjens
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: End-stage renal disease is associated with premature ageing of the T-cell immune system. At the time of kidney transplantation the average biological age of…
2019 American Transplant Congress
A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy
J. Zuber¹, O. Boyer¹, B. Neven¹, R. Berthaud¹, M. Ould Rabah¹, I. Jollet², V. Renac², F. Pirenne², S. Gross², R. Djoudi², P. Tiberghien², J. Taupin³, S. Blanche¹, R. Salomon¹
¹Paris Descartes University, Paris, France, ²Etablissement Français du Sang, Paris, France, ³Department of Immunology and Histocompatibility, St Louis Hospital, Paris, France
*Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…
2019 American Transplant Congress
Impact of Liver Recipient Genotype on Tacrolimus
S. Tremblay¹, T. Fukuda², T. Mizuno², A. A. Vinks², E. Woodle¹, J. Klawitter³, J. Klawitter³, U. Christians³, R. R. Alloway¹
¹University of Cincinnati, Cincinnati, OH, ²Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ³iC42 Clinical Research and Development, Aurora, CO
*Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…
2019 American Transplant Congress
Galectin-3 and Long-Term Graft Failure in Renal Transplant Recipients: A Prospective Cohort Study
C. G. Sotomayor¹, C. A. Keyzer¹, J. L. Anderson¹, R. O. Gans², I. M. Nolte³, M. H. de Borst¹, S. P. Berger¹, G. J. Navis¹, R. A. de Boer⁴, S. J. Bakker¹
¹Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands, ²Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands, ³Department of Epidemiology, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Cardiology, University Medical Center Groningen, Groningen, Netherlands
*Purpose: Galectin-3 has been associated with renal fibrosis and decline of renal function. We aimed to determine the association of galectin-3 with long-term risk of…
2019 American Transplant Congress
IL-6R Blockade with Tocilizumab Increases Tregs and Decreases Early Graft Inflammation in Kidney Transplant Recipients: Results of a Randomized Controlled Trial
S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Joanes, F. Vincenti
UCSF, San Francisco, CA
*Purpose: IL-6, a proinflammatory cytokine and key regulator of Treg/Th17 balance, is strongly associated with renal graft rejection. We hypothesized that IL-6 blockade with tocilizumab…