Am J Transplant, Volume 19, Suppl 3 Archives - Page 154 of 214 - ATC Abstracts

2019 American Transplant Congress
NK Cell Quantification by Paraffin Immunohistochemistry is Not Predictive of Graft Outcome in 1-Year Surveillance Biopsies
J. Barnes¹, F. Suliman², A. Shammout¹, E. A. Farkash¹
¹Pathology, Michigan Medicine, Ann Arbor, MI, ²Nephrology, Michigan Medicine, Ann Arbor, MI
*Purpose: Molecular and animal studies have identified NK cells as important mediators and markers of antibody mediated rejection. Using three color immunohistochemistry for CD16, T-bet,…
2019 American Transplant Congress
Matrix Metalloproteinase-9 and Neutrophil Extracellular Traps in Human and Mouse Liver Ischemia and Reperfusion Injury
S. Duarte, A. Zarrinpar, R. W. Busuttil, A. J. Coito
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Neutrophils are key mediators of ischemia/reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Once activated, they release nuclear DNA web-like structures called neutrophil extracellular…
2019 American Transplant Congress
Back Signaling of HLA Class I Molecules and NK Cell Receptor Ligands in Renal Epithelial Cells Contributes to the Rejection-Specific Microenvironment
E. Chichelnitskiy¹, J. Egelkamp¹, K. Daemen¹, J. Keil¹, C. Neudörfl¹, J. Bräsen², J. Schmitz², H. Haller³, C. Blume⁴, C. Falk⁵
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Nephropathology Unit, Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany, ⁴Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; Institute of Technical Chemistry, Leibniz University, Hannover, Germany, ⁵Institute of Transplant Immunology, Hannover Medical School; DZIF, German Center for Infection Research, TTU-IICH, Hannover/Braunschweig, Germany
*Purpose: During the last years, diverse harming mechanisms of donor-specific antibodies (DSA) to endothelial cells have been studied accompanied by an emerging evidence of NK…
2019 American Transplant Congress
The Impact of KDPI on Post Transplant Kidney Function: Intercept versus Slope. A Single Center Study
M. Molinari¹, D. Jorgensen², R. Mehta³, P. Sood³, A. Ganoza², C. Puttarajappa³, R. Lopez², M. Wijkstrom², A. Tevar², S. Hariharan³
¹University of Pittsburgh Medical Centre, Pittsburgh, PA, ²Surgery, University of Pittsburgh Medical Centre, Pittsburgh, PA, ³Medicine, University of Pittsburgh Medical Centre, Pittsburgh, PA
*Purpose: We evaluated the impact of Kidney Donor Profile Index (KDPI) on post-transplant renal function and graft survival.*Methods: Between January-2013 and December- 2017, a total…
2019 American Transplant Congress
Long-Term Efficacy and Safety of Everolimus Based Immunosuppression on De Novo Kidney Transplantation with 10 Years Follow-Up
Y. Watarai¹, S. Narumi¹, T. Tomosugi¹, K. Futamura², M. Okada¹, M. Tsujita², T. Hiramitsu¹, T. Kobayashi³, N. Goto²
¹Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan, ²Transplant Nephrology, Nagoya Daini Red Cross Hospital, Nagoya, Japan, ³Kidney Transplantation, Aichi Medical University, Nagoya, Japan
*Purpose: Long-term efficacy and safety of everolimus (EVR) based immunosuppression for de novo kidney transplant recipient who were involved in A1202 study from our institute…
2019 American Transplant Congress
Clinical Implications of Belatacept Conversion in a High-Risk, Urban Renal Transplant Population
B. Valdepenas, J. Benken, E. Benedetti, Z. Hajjiri, A. Lichvar
University of Illinois at Chicago, Chicago, IL
*Purpose: Conversion to belatacept as maintenance immunosuppression has gained traction to prevent calcineurin inhibitor (CNI) induced toxicities in renal transplant (RTx) recipients. However, limited knowledge…
2019 American Transplant Congress
Calcineurin Inhibitor Holiday for Management of Post Transplant Acute Kidney Injury
S. Sriperumbuduri, D. Lazarus, T. Fairhead, S. Hoar, J. Karpinski, G. Knoll
Nephrology, The Ottawa hospital, Ottawa, ON, Canada
*Purpose: Calcineurin inhibitors (CNI), despite dominating the armamentarium of post transplant medications, are associated with long term nephrotoxicity and also delayed recovery of renal function…
2019 American Transplant Congress
Long-Term Outcomes of Early Conversion to Sirolimus-Based Immunosuppression in Children with Living Donor Kidney Transplants
B. Stotter¹, S. Lui¹, E. Weller², L. Ganapathi¹, M. Ferguson¹, A. Traum¹, M. Somers¹, N. Rodig¹
¹Pediatrics, Boston Children's Hospital, Boston, MA, ²Biostatistics and Research Design Center, Boston Children's Hospital, Boston, MA
*Purpose: Following kidney transplantation (KTx), calcineurin inhibitor (CNI)-based maintenance immunosuppression (IS) can be associated with nephrotoxicity and other complications including viral infections and malignancy. Mammalian…
2019 American Transplant Congress
Outcomes of En Bloc Simultaneous Liver-Kidney Transplantation Compared to the Traditional Technique
A. R. Cortez, T. C. Lee, A. Kassam, M. C. Morris, L. K. Winer, L. Sage Silski, M. C. Cuffy, T. S. Diwan, R. C. Quillin, S. A. Shah
University of Cincinnati, Cincinnati, OH
*Purpose: Simultaneous liver-kidney transplantation (SLKT) is indicated for patients with end-stage liver disease (ESLD) and concurrent renal insufficiency. En bloc SLKT has been reported as…
2019 American Transplant Congress
Liver Transplant Centers Select Different Characteristics for Recipients and Deceased Donors: Implications for Patients When Choosing a Center
C. R. Schaffhausen¹, M. J. Bruin², S. Chu², D. Schladt¹, S. Chinnakotla³, J. R. Lake⁴, W. Kim⁵, S. W. Biggins⁶, J. J. Snyder⁷, B. L. Kasiske⁷, A. K. Israni¹
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²College of Design, University of Minnesota, Minneapolis, MN, ³Department of Surgery, University of Minnesota, Minneapolis, MN, ⁴Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, MN, ⁵Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA, ⁶Division of Gastroenterology, University of Washington, Seattle, WA, ⁷Scientific Registry of Transplant Recipients, Minneapolis, MN
*Purpose: When patients can choose the liver transplant center at which to establish care, a prior knowledge of center acceptance practices (of candidates and donors)…