Am J Transplant, Volume 19, Suppl 3 Archives - Page 150 of 214 - ATC Abstracts

2019 American Transplant Congress
Differences in CMV-Specific CD4 T Cell Population in De Novo Kidney Transplant Recipients Treated with Everolimus-Based Regimen Compared to a Standard Tacrolimus-MPA Regimen: Results from ATHENA
I. A. Hauser¹, S. Marx¹, C. Sommerer¹, B. Suwelack¹, D. Dragun¹, O. Witzke¹, F. Lehner¹, I. Kroeger², M. Junge², F. Thaiss¹, B. Nashan¹, M. Sester¹
¹ATHENA, CMV Substudy Group, Germany, ²Novartis, Pharma GmbH, Germany
*Purpose: The ATHENA trial was designed to compare everolimus [EVR] in combination with tacrolimus [TAC] or cyclosporine A [CyA] vs. a standard regimen of mycophenolic…
2019 American Transplant Congress
Complement Blockade in Kidney Recipients Prevents Delayed Graft Function and Antibody-Mediated Rejection in Non-Human Primates
M. Eerhart¹, J. Reyes¹, C. Blanton¹, J. Danobeitia¹, P. Chlebeck¹, L. Zitur¹, J. Coonen¹, S. Capuano¹, A. D’Alessandro¹, J. Torrealba², W. Zhong¹, Y. Yankol¹, L. Fernandez¹
¹University of Wisconsin, Madison, WI, ²UT Southwestern, Dallas, TX
*Purpose: Ischemia-reperfusion injury (IRI) leading to inflammation, complement activation, cytokine release and acute kidney injury has been implicated in the mechanism for delayed graft function…
2019 American Transplant Congress
Clinical Implications of Serum Mac-2 Binding Protein in Regular Follow Up after Pediatric Living Donor Liver Transplantation
T. Ueno¹, T. Kodama¹, Y. Noguchi¹, M. Nomura¹, R. Saka¹, Y. Takama¹, Y. Tazuke¹, K. Bessho², H. Okuyama¹
¹Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan, ²Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan
*Purpose: Pediatric living donor liver transplant (LDLT) patients sometimes develops graft fibrosis. They showed graft fibrosis even if their liver function tests were within normal…
2019 American Transplant Congress
The Role of the T Regulatory Cell Compartment in Intestinal Transplant Patients: Helpful or Unhinged?
L. Belyayev¹, M. Sadat², K. Loh³, S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. M. Fishbein², A. Kroemer²
¹Surgery, Walter Reed National Military Medical Center, Bethesda, MD, ²Transplant, MedStar Georgetown Transplant Institute, Washington D.C., DC, ³Pediatrics, Children’s National Medical Center, Washington D.C., DC
*Purpose: The T regulatory (Treg) cell compartment has now been established as a key player in dampening T helper 17 (Th17) mediated inflammation, managing self-tolerance,…
2019 American Transplant Congress
Donor-Derived Cell-Free DNA in Urine Identifies BKVN with Graft Injury in BK Viruria Kidney Transplant Recipients
G. Huang¹, X. Chen¹, S. Yang², W. Chen², P. Chen³, X. Hou⁴, T. Jiang⁵, H. Liu⁵, X. Li⁵, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ³Department of clinical laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁴Guangzhou KingMed Center for Clinical Laboratory Co.,Ltd., Guangzhou, China, ⁵Research and Development, AlloDx Biotech Co.Ltd., Suzhou, China
*Purpose: BK Polyomavirus nephropathy (BKVN) is an important cause of dysfunction and failure of renal transplants. Elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the…
2019 American Transplant Congress
The Model For Predicting eGFR At A Year After Donation In Living Related Kidney Transplant Donors
K. Shinoda, K. Sakurabayashi, T. Mizutani, Y. Takahashi, Y. Hyodo, Y. Itabashi, M. Muramatsu, T. Kawamura, S. Shishido, K. Sakai
Nephrology, Toho University Faculty of Medicine, Tokyo, Japan
*Purpose: Predicting post-donation kidney function precisely is considerably beneficial for both candidates of living-related kidney donors and their physicians when judging the feasibility of kidney…
2019 American Transplant Congress
Patterns and Predictors of Alcohol Use after Early Liver Transplant for Alcoholic Hepatitis
B. P. Lee¹, M. Rinella², G. Im³, J. Rice⁴, O. Fix⁵, G. Therapondos⁶, H. Han⁷, D. Victor⁸, E. Weinberg⁹, C. Hsu¹⁰, M. Voigt¹¹, H. Maddur², S. Eswaran¹², D. Foley⁴, R. Ghobrial⁸, L. Dinges⁵, J. Dodge¹, N. Mehta¹, M. Lucey⁴, N. Terrault¹
¹UCSF, SF, CA, ²NW, Chicago, IL, ³MtSinai, NYC, NY, ⁴Wisconsin, Madison, WI, ⁵Swedish, Seattle, WA, ⁶Ochsner, Jefferson, LA, ⁷USC, LA, CA, ⁸Houston, Houston, TX, ⁹Penn, Philadelphia, PA, ¹⁰Georgetown, DC, WA, ¹¹Iowa, Iowa City, IA, ¹²Rush, Chicago, IL
*Purpose: ACCELERATE-AH is a multicenter consortium studying early liver transplant (LT) for alcoholic hepatitis (AH). To inform surveillance and intervention strategies for post-LT alcohol use,…
2019 American Transplant Congress
Monitoring Circulating T Follicular Helper Cells Polarization, Activation and Function Distinguishes Asymptomatic Donor-Specific Anti-HLA Antibody Positive Kidney Transplant Recipients from Those Undergoing Antibody-Mediated Rejection
C. Macedo¹, K. Louis¹, P. Fadakar², M. Yamada², B. Elinoff¹, K. Hadi¹, P. Randhawa¹, D. Metes¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx).…
2019 American Transplant Congress
Differentiation and Characterization of Human Endodermal Precursors for Liver Cell Therapies
W. S. Fagg¹, N. Liu¹, M. Shoja¹, I. Patrikeev², M. Motamedi², J. Fair¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX
*Purpose: Mouse pluripotent stem cell (PSC)-derived endoderm precursors (EPs) have small size, endoderm lineage gene expression signatures, and high proliferation rates, that allow engraftment in…
2019 American Transplant Congress
Improving the Organ Donation Process: Updated
J. Yeh, M. P. Jarrett, L. Teperman
Northwell Health, New Hyde Park, NY
*Purpose: Due to the complexity of care that each ICU patient requires, the bedside nurse may miss the clinical trigger that would indicate an appropriate…