Am J Transplant, Volume 19, Suppl 3 Archives - Page 147 of 214 - ATC Abstracts

2019 American Transplant Congress
Significant Increase in Moderate to High KDPI Kidney Transplants Using a Multi-Operational Approach: Results from the COIIN (Collaborative Innovation and Improvement Network) Initiative
T. Pesavento¹, J. Foutz², K. Sisaithong², D. Klassen², L. Stillion¹, A. Rajab¹, R. Pelletier³, K. Washburn¹, H. Tosoc-Haskell²
¹Ohio State University, Columbus, OH, ²UNOS, Richmond, VA, ³Robert Wood Johnson, New Brunswick, NJ
*Purpose: Kidney transplant (KTx) utilization of moderate to high KDPI (MH-KDPI) deceased donor kidneys remains an opportunity to reduce organ discards. We participated in COIIN,…
2019 American Transplant Congress
Early Use of Everolimus Plus Reduced Tacrolimus vs Standard Tacrolimus in De Novo Livertransplant Recipients: 12 Months Efficacy and Safety Data from HEPHAISTOS Study
B. Nashan¹, P. Schemmer¹, H. Schlitt¹, A. Pascher¹, C. Klein¹, U. Neumann¹, I. Kroeger², P. Wimmer², F. Braun¹
¹Study Group, Hephaistos, Germany, ²Novartis Pharma GmbH, Nuernberg, Germany
*Purpose: The HEPHAISTOS study was set up to compare early use of everolimus [EVR] combined with reduced tacrolimus [rTAC] versus standard-dose tacrolimus [TAC-C) in de…
2019 American Transplant Congress
Circulating T Follicular Helper Proliferation And Memory B Cell Activation Correlate With Donor Specific Allo-antibody Occurrence And Antibody-mediated Rejection After Kidney Transplantation
K. Louis¹, C. Macedo¹, M. Marrari¹, B. Ramaswami¹, M. Lucas¹, B. Elinoff¹, M. Yamada¹, X. Gu¹, G. Chalasani¹, A. Zeevi¹, P. Randhawa¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm Unité mixte de recherche 1160, Paris, France
*Purpose: Crosstalk between T follicular helper (Tfh) cells and B cells is necessary for class-switched antibody generation. The contribution of memory Tfh and B cells…
2019 American Transplant Congress
Ligation Of Hla Class Il Molecules Disrupts Endothelial Barrier Through Src-dependent Ve-cadherin Destabilization
F. Li¹, R. A. Sosa¹, N. M. Valenzuela¹, E. Rozengurt², E. F. Reed¹
¹Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA, ²Digestive Diseases Research Center, University of California, Los Angeles, Los Angeles, CA
*Purpose: Microvascular inflammation, vascular permeability, and accumulation of intravascular mononuclear cells are characteristics of acute and chronic antibody-mediated rejection. Vascular endothelial cadherin (VE-Cadherin) is a…
2019 American Transplant Congress
Incidence and Risk of Allograft Rejection after Cardiac Transplantation in Left Ventricular Assist Device Patients
R. C. Patel¹, L. B. Cooper², S. D. Barnett², R. T. Cole², M. A. Psotka², A. Cochrane², S. Sinha², L. J. Bogar², S. S. Desai², P. Shah²
¹Virginia Commonwealth University School of Medicine, Inova Fairfax Hospital, Falls Church, VA, ²Department of Heart Failure and Transplant, Inova Heart and Vascular Institute, Falls Church, VA
*Purpose: Left ventricular assist devices (LVAD) are made of biomaterials that have been shown to cause allosensitization. Single center studies have suggested that patients bridged…
2019 American Transplant Congress
Early Steroid Withdrawal in African American Deceased Donor Renal Transplant Recipients with Alemtuzumab Induction: Is Graft Loss on the Horizon?
R. Lynn, B. Ravichandran, T. Sparkes, A. Haririan, J. Bromberg, J. Casale
University of Maryland Medical Center, Baltimore, MD
*Purpose: The safety of early steroid withdrawal (ESW) in African American (AA) deceased donor renal transplant recipients (DDRTs) is unclear. This study assessed the impact…
2019 American Transplant Congress
The Evolution of Body Mass Index after Kidney Transplantation in Recipients with a Previous Laparoscopic Sleeve Gastrectomy
G. Chan, F. Briere
Universite de Montreal, Hopital Maisonneuve-Rosemont, Montreal, QC, Canada
*Purpose: Bariatric surgery is one of the most common operations. Laparoscopic sleeve gastrectomy (LSG) has been reported to prepare candidates for listing. However, weight gain…
2019 American Transplant Congress
Transplant Center Practices Are the Primary Drivers of United States Donation after Circulatory Death Liver Transplantation
L. Beal¹, D. T. Nguyen², T. Menser³, S. Zajac¹, E. A. Graviss², M. J. Hobeika¹
¹Department of Surgery, Houston Methodist Hospital, Houston, TX, ²Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, TX, ³Center for Outcomes Research, Houston Methodist Research Institute, Houston, TX
*Purpose: We hypothesize that a few high-utilization donation after circulatory death (DCD) liver centers are the primary drivers of the dissimilar rates of DCD liver…
2019 American Transplant Congress
Role of MHC Class II in B Cell and Regulatory T Cell Development
S. K. Germana, Z. Wang, C. A. Huang, L. Kojima, C. G. Rickert, J. F. Markmann, C. LeGuern
Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Therapies involving CD4 regulatory T cells (Tregs) are promising approaches to mitigate graft rejection and autoimmunity. Understanding of the activation mechanisms that initiate Treg…
2019 American Transplant Congress
B Cell-Specific IRE1a Deficiency Protects Renal Allografts from Rejection via Inhibition of Donor-Specific Antibodies and Induction of B Regulatory Cells
L. Qiu¹, J. Wang¹, X. Yeap¹, D. Fang², Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Despite the progress in immunosuppressive regimens, antibody-mediated rejection remains a major contributor to renal allograft loss in recipients with donor-specific antibodies (DSA). IRE1a, an…