Am J Transplant, Volume 19, Suppl 3 Archives - Page 14 of 214 - ATC Abstracts

2019 American Transplant Congress
Responder B Cell Depletion Increased Allo-Reactive Regulatory T Cells Generated in Allo-Anergization
N. Tanimine¹, L. Contreras-Ruiz², K. Deng¹, N. Feeney¹, C. Rickert¹, K. Lee¹, E. Guinan³, J. Markmann¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, ³Department of Radiation Oncology, Dana Farber Cancer Institute, Boston, MA
*Purpose: Regulatory T cells (Tregs) are promising tool for induction and maintenance of transplantation tolerance. We have done a feasibility trial in kidney transplant recipients…
2019 American Transplant Congress
The Effects of Chronic Kidney Disease on Antiviral T Cell Response
R. L. Crepeau¹, H. Li², L. P. Daley-Bauer³, M. L. Ford¹, P. D. Winterberg²
¹Emory Transplant Center, Atlanta, GA, ²Pediatrics, Emory University School of Medicine, Atlanta, GA, ³Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). Cytomegalovirus (CMV) establishes…
2019 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens (Cardiac Myosin and Vimentin) and De Novo Development of Antibodies to Cardiac Self-Antigens Precedes Chronic Cardiac Allograft Rejection
R. Ravichandran, Y. Itabashi, W. Liu, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the kinetics of induction of circulating exosomes with cardiac self-antigens (SAgs), cardiac myosin (MYO) and Vimentin…
2019 American Transplant Congress
Poor Outcomes in Kidney Transplant Candidates & Recipients with History of Falls
N. Chu¹, H. Ying¹, Z. Shi¹, C. Haugen¹, S. Norman², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins, Baltimore, MD, ²Michigan Medical Center, Ann Arbor, MI
*Purpose: In patients with ESRD, serious fall injuries (e.g. fractures) are associated with decreased chance of listing or transplantation. It is likely that KT candidates…
2019 American Transplant Congress
Impact of Donor Hepatitis C Virus Infection on Kidney Transplant Outcomes in the Direct Acting Antiretroviral Era: Time to Revise the KDPI?
R. M. Cannon, E. G. Davis, L. Mackelaite, H. Dave, M. Eng, C. M. Jones
University of Louisville, Louisville, KY
*Purpose: The kidney donor risk index (KDRI), upon which the kidney donor profile index (KDPI) used for renal allocation is based, was derived before the…
2019 American Transplant Congress
Eight-Year Outcomes Following ABO-Incompatible Kidney Transplantation Performed after Desensitization by Antigen-Unspecific Immunoadsorption Devices
C. Speer¹, F. Kälble¹, L. Pego da Silva¹, C. Nusshag¹, M. Schaier¹, C. Süsal², C. Sommerer¹, M. Zeier¹, C. Morath¹
¹Nephrology, University of Heidelberg, Heidelberg, Germany, ²Immunology, University of Heidelberg, Heidelberg, Germany
*Purpose: Owing to the unmet need of available kidney grafts, ABO-incompatible kidney transplantation (KTX) has been established to enlarge the possible donor pool. The current…
2019 American Transplant Congress
Risk Factors for 1-5 Year De Novo Cancers after Kidney Transplant (KTx) with First-Year Immunosuppression (IS) Data: An Analysis of the Choosing Immune Suppression by Efficacy and Morbidity (CISTEM) Study
V. Dharnidharka¹, D. Axelrod², Z. Zhang³, M. Schnitzler³, K. Lentine³, B. Kasiske⁴
¹Washington Univ, St. Louis, MO, ²Univ of Iowa, Iowa City, IA, ³Saint Louis Univ, St. Louis, MO, ⁴SRTR, Minneapolis, MN
*Purpose: From our CISTEM study of linked national registries, we published data on risk factors for within-3-years post-KTx non-melanoma skin cancer (NMSC) and viral-driven cancers…
2019 American Transplant Congress
Microparticle Delivery to Lymph Nodes Induces Specific Suppression to Prolong Islet Survival
Y. Xiong¹, L. Tostanoski², C. Jewell³, J. Bromberg¹
¹Surgery, U. Maryland, Baltimore, MD, ²U.Maryland, Baltimore, MD, ³U. Maryland, College Park, MD
*Purpose: Microparticles (MP) loaded with peptide antigen plus other immune signals and delivered directly into lymph nodes (LN) can result in either proinflammatory or antiinflammatory…
2019 American Transplant Congress
Minimizing Kidney Ischemia Reperfusion Injury by Transferring Exogenous Mitochondria
A. Bajwa¹, V. Bontha¹, J. Eason², D. Maluf³, V. Mas⁴
¹UT, Memphis, TN, ²Director of Transplant Institute. UTHSC, Memphis, TN, ³UTHSC, Memphis, TN, ⁴Director of Transplant Research Institute. UTHSC, Memphis, TN
*Purpose: Ischemia induces altered bioenergetics with increased mitochondrial swelling and reactive oxygen species (ROS) and ultimately degradation of cellular function. Ischemia followed by reperfusion (IRI)…
2019 American Transplant Congress
Multi-Omics Approach to Accurately Assess Early Graft Injury in Liver Transplantation
D. Maluf¹, V. Sai Bontha¹, A. Bajwa¹, R. Helmick¹, P. J. Horton¹, C. Eymard¹, J. Eason², V. Mas³
¹UTHSC, Memphis, TN, ²UTHSC. Director of Transplant Institute, Memphis, TN, ³UTHSC Director Transplant Research Institute, Memphis, TN
*Purpose: We investigated global DNA methylation (DNAm) patterns during ischemia reperfusion (I/R) injury in liver transplant (LT) patients, and their role on regulating gene expression…