ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Exosomes Carry Stress and Damage Specific miRNAs during Peritransplant Period in TPIAT

    P. Saravanan1, M. Kanak1, S. Vasu2, M. Lawrence2, M. Levy1, B. Naziruddin3

    1Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, 2Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, 3Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX

    *Purpose: Innate inflammation and hypoxia during peritransplant period significantly affect survival of islet grafts. Markers that can identify stress and/or damage during this early period…
  • 2019 American Transplant Congress

    A Prognostic Model to Identify Deceased Donor Kidney Transplant Recipients at High Risk for Delayed Graft Function

    S. Kawakita, J. L. Beaumont, M. J. Everly

    Terasaki Research Institute, Los Angeles, CA

    *Purpose: We have previously identified pre-transplant risk factors for delayed graft function (DGF) in deceased donor kidney transplant (DDKT) recipients and built a machine learning…
  • 2019 American Transplant Congress

    Subtyping Of Histologically Stable Kidney Transplants In Molecular Meta-analysis

    D. Rychkov1, T. Sigdel2, J. Liberto2, M. Sarwal2, M. Sirota3

    1ICHS, Department of Surgery, UCSF, San Francisco, CA, 2Department of Surgery, UCSF, San Francisco, CA, 3ICHS, UCSF, San Francisco, CA

    *Purpose: Histologically stable allografts have been shown to have molecular inflammation by prior gene expression studies. Nevertheless, there are no methodologies in place to sub-group…
  • 2019 American Transplant Congress

    RNA Sequencing Identifies a Differential Role of Coding and Non-Coding Genes by Types of Rejection

    S. Pineda1, O. Bestard2, T. K. Sigdel1, M. Sirota3, M. Sarwal1

    1Department of Surgery, UCSF, San Francisco, CA, 2Department of Surgery, Bellvitge University Hospital, Barcelona, Spain, 3BCHSI, UCSF, San Francisco, CA

    *Purpose: The differentiation of histological phenotypes of T cell mediated cellular rejection (TCMR) and humoral or antibody mediated rejection (AMR) of kidney allografts, bears relevance…
  • 2019 American Transplant Congress

    Significance of Histopathologic Features for Predicting Progression in Patients with Transplant Glomerulopathy

    X. Li, J. Chen, D. Cheng, R. Wang, W. Wang, M. Zhang, F. Xu, J. Wen, Z. Tang

    National Clinical Research Center of Kidney Diseases, Nanjing, China

    *Purpose: Transplant glomerulopathy (TG) represents a major cause of long-term allograft failure and is the leading cause of overall post-transplant proteinuria. We aimed to determine…
  • 2019 American Transplant Congress

    Investigating Deceased Donor Kidney Discard Trend – An Opportunity To Expand The Donor Pool

    J. A. Shah1, D. P. Borle1, K. Koontz2, W. Irish1, K. V. Ravindra1

    1Abdominal Transplant Surgery, Duke University Medical Center, Durham, NC, 2Carolina Donor Services, Durham, NC

    *Purpose: As the number of patients awaiting kidney transplantation increases from year to year, centers must maximize efforts to transplant kidneys procured. One way of…
  • 2019 American Transplant Congress

    DR53, You Can’t See Me: A Deceased Donor Tale of Ambiguous Typing

    S. Dionne1, S. Shetty1, L. Santiago1, K. Klama2

    1VRL Eurofins, Centennial, CO, 2VRL Eurofins, Philadelphia, PA

    *Purpose: Our laboratory performs STAT HLA typing for an OPO using RT-PCR methodology. A 46 year old, male Caucasian deceased donor was worked up by…
  • 2019 American Transplant Congress

    Time within Therapeutic Range: A Comparison of Three Tacrolimus Formulations within Ninety Days of Renal Transplant

    S. Patel, K. Khalil, A. Lichvar, E. Benedetti, P. West-Thielke

    University of Illinois Hospital and Health Sciences System, Chicago, IL

    *Purpose: Optimizing tacrolimus (TAC) time within therapeutic range (TTR) has been shown to improve outcomes post-transplant. To date, there are no studies assessing differences in…
  • 2019 American Transplant Congress

    Belatacept Use in High Kidney Donor Profile Index Kidney Transplant Recipients

    D. Britt1, A. Gharabagi1, K. Botkin1, T. Horwedel2, C. Carthon1, J. Hagopian1

    1Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, 2Veloxis Pharmaceuticals, Cary, NC

    *Purpose: To determine whether the use of belatacept is associated with renal function preservation in kidney transplant recipients from donors with a kidney donor profile…
  • 2019 American Transplant Congress

    Impact of HLA-DR Matching on HLA-DQ Matching Status and the Development of Anti-HLA-DQ De Novo DSA under Calcineurin Inhibitor or Belatacept Immunosuppression

    V. Jucaud1, H. Gebel2, R. Bray2, M. Polinsky3, M. Everly1

    1Terasaki Research Institute, Los Angeles, CA, 2Emory University, Atlanta, GA, 3Bristol-Myers Squibb, Princeton, NJ

    *Purpose: De novo donor-specific HLA antibodies (dnDSA) that develop after kidney transplantation target more frequently allo-HLA-DQ antigens in comparison to other allo-HLA antigens. Yet, organ…
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