ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Role of Procurement and Reperfusion Biopsy in Kidney Transplant in Evaluating and Predicting Outcomes of Deceased Donor Kidneys

    S. Faiz, A. Pai, A. De Golovine, A. Edwards, W. Glass, A. Tchakarov

    UT Houston, Houston, TX

    *Purpose: Pathologic assessment of donor organs by use of procurement biopsies (PB) provides information regarding organ quality. Most commonly cited reason for organ discard is…
  • 2019 American Transplant Congress

    Treatment Modality Affects Outcomes of Recurrent Hepatocellular Carcinoma Following Liver Transplantation: A US Multicenter Analysis of 2786 Patients

    P. Tabrizian1, K. J. Halazun2, M. L. Holzner1, N. Mehta3, F. Y. Yao3, J. Roberts3, J. C. Emond4, B. Samstein2, R. S. Brown4, S. Florman1, M. E. Schwartz1, M. M. Doyle5, W. C. Chapman5, M. Najjar4, R. W. Busuttil6, V. G. Agopian6

    1Transplant, Mount Sinai Medical Center, New York, NY, 2Transplant, Weill Cornell Medicine, New York, NY, 3Transplant, University of California San Francisco, San Francisco, CA, 4Transplant, Columbia University Medical Center, New York, NY, 5Transplant, Washington University School of Medicine, St Louis, MO, 6Transplant, David Geffen School of Medicine at UCLA, Los Angeles, CA

    *Purpose: Recurrent hepatocellular carcinoma (HCC) following liver transplantation (LT) has a poor prognosis. We evaluated the impact of treatment modalities on post-recurrence survival.*Methods: Adult patients…
  • 2019 American Transplant Congress

    Immunomics of Renal Allograft Acute T-Cell Mediated Rejection Biopsies of Tacrolimus- and Belatacept- Treated Patients

    M. van der Zwan1, C. C. Baan1, R. C. Colvin2, R. N. Smith2, R. A. White2, D. N. Ndishabandi2, A. L. Nigg1, T. P. van den Bosch1, G. N. de Graav1, M. C. Clahsen-van Groningen1, D. A. Hesselink1

    1Internal Medicine, Division Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands, 2Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA

    *Purpose: Belatacept-based therapy in kidney transplant recipient has been shown to increase long-term renal allograft and patient survival compared with calcineurin inhibitor based therapy, however…
  • 2019 American Transplant Congress

    Recipient Monocytes Activated by Endobronchial Toll-Like Receptor 2 Agonist Prevent Tolerance Induction after Lung Transplantation

    S. Tanaka1, J. M. Gauthier1, Y. Terada1, T. Takahashi1, W. Li1, R. Higashikubo1, A. Y. Tong1, V. Puri1, A. S. Krupnick2, A. E. Gelman1, D. Kreisel1

    1Department of Surgery, Washington University in St. Louis, St. Louis, MO, 2Department of Surgery, The University of Virginia, Charlottesville, VA

    *Purpose: Extended criteria lung donors are being increasingly utilized, raising the possibility of transplanting lungs with a pre-existing pneumonia; how donor pneumonia alters alloimmune responses,…
  • 2019 American Transplant Congress

    Interleukin-27 is Required for Donor Specific Antibody Production in Response to Heart Allograft Transplantation

    M. Nicosia, S. Miyairi, R. Fan, A. Beavers, V. Gorbacheva, A. Valujskikh

    Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

    *Purpose: Interleukin-27 (IL-27), a member of IL-12 cytokine family, is involved in both pro- and anti-inflammatory immune responses. Previously we reported that B cell derived…
  • 2019 American Transplant Congress

    Trends in Vascularized Composite Allograft Transplantation in the United States

    J. Wainright1, C. Wholley2, W. Cherikh1, D. Klassen3

    1Research, UNOS, Richmond, VA, 2Policy and Community Relations, UNOS, Richmond, VA, 3Office of Chief Medical Officer, UNOS, Richmond, VA

    *Purpose: Characterize patterns in VCA transplantation in the U.S.*Methods: Analyses include all VCA recipients in the U.S through October 2018 and all VCA candidates between…
  • 2019 American Transplant Congress

    Clinical Response to Pathological Finding in Uterus Transplantation

    L. Johannesson, G. Testa

    Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX

    *Purpose: Uterus transplantation has recently proven to be the first successful treatment for absolute uterine factor infertility with demonstration of live births. All reported episodes…
  • 2019 American Transplant Congress

    Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation

    F. Wandrer1, B. Wiegmann2, N. Ledwoch1, R. Bellmas Sanz1, F. Ius2, W. Sommer2, S. Rojas2, C. Kühn2, I. Tudorache2, M. Avsar2, A. Haverich2, G. Warnecke2, C. S. Falk1

    1Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany

    *Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation (Tx) but rarely compared directly in a clinical setting. Therefore, we compared a…
  • 2019 American Transplant Congress

    Determining the Molecular Nature and Role of Cytoglobin in Chronic Allograft Nephropathy

    D. Patel1, T. Divanyan1, E. Acosta1, K. Carnes2, D. Howard3, F. Jourd’heuil3, D. Jourd’heuil3, R. Lopez-Soler4

    1Albany Medical College, Albany, NY, 2Urology, Albany Medical College, Albany, NY, 3Molecular and Cellular Physiology, Albany Medical College, Albany, NY, 4Surgery, Section of Transplantation, Albany Medical College, Albany, NY

    *Purpose: Although it is usually accepted that the kidney is prone to hypoxic injury, the importance of hypoxia in chronic kidney disease (CKD) as well…
  • 2019 American Transplant Congress

    Assessment of Culture/Preservation Conditions on Survival and Function of Islets

    Y. Shindo, M. F. Levy, M. A. Kanak

    Surgery, Virginia Commonwealth University, Richmond, VA

    *Purpose: Culture or preservation of human islets prior to transplantation has been adopted by various centers because it may reduce immunogenicity, suppress exocrine contamination and…
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