Am J Transplant, Volume 19, Suppl 3 Archives - Page 138 of 214 - ATC Abstracts

2019 American Transplant Congress
Engineering Regulatory T Cells With TCR-Signaling-Responsive Interleukin 2 Nanoparticles Provides In Situ Suppression Of Alloimmunity
S. K. Eskandari¹, M. B. Melo², I. Sulkaj¹, N. Li², S. Cai¹, H. Allos¹, J. Y. Choi¹, D. J. Irvine², J. R. Azzi¹
¹Harvard Medical School, Brigham and Women's Hospital, Boston, MA, ²David H. Koch Institute for Integrative Cancer Research, Cambridge, MA
*Purpose: Adoptive cell transfer of regulatory T cells (TReg) has shown great potential in animal models of auto- and alloimmunity. The translation of TReg therapies…
2019 American Transplant Congress
Development of a Pharmacy Collaborative Practice Agreement to Improve Efficiency and Management of Prescribing in a Renal Transplant Clinic
R. Chelewski¹, K. Johnson¹, A. Zuckerman², J. DeClercq³, L. Choi³, M. Peter², A. J. Langone⁴
¹Vanderbilt Specialty Pharmacy Services, Vanderbilt Univ Medical Ctr, Nashville, TN, ²Department of Pharmacy, Vanderbilt Univ Medical Ctr, Nashville, TN, ³Department of Biostatistics, Vanderbilt Univ Medical Ctr, Nashville, TN, ⁴Division of Nephrology, Vanderbilt Univ Medical Ctr, Nashville, TN
*Purpose: This study describes the development of a Collaborative Pharmacy Practice Agreement (CPPA) between transplant pharmacists and physicians and assesses change in prescription volume and…
2019 American Transplant Congress
Three-Year Outcomes of Highly-Sensitized Kidney Transplant Recipients Desensitized with Imlifidase (IdeS)
E. Huang¹, J. Choi¹, A. Vo¹, A. Peng¹, R. Najjar¹, S. Sethi¹, C. Kjellman², L. Winstedt², N. Ammerman¹, S. C. Jordan¹
¹Cedars Sinai Medical Center, Los Angeles, CA, ²Hansa Medical, Lund, Sweden
*Purpose: The HLA-incompatible (HLAi) barrier has been traversed using desensitization therapies with IVIg, rituximab and/or plasmapheresis, although antibody-mediated rejection (ABMR) continues to be observed in…
2019 American Transplant Congress
Effect of Chronic Kidney Disease on Allo-Immune Response in Mice
P. D. Winterberg¹, H. Li¹, M. E. Wagener², M. L. Ford²
¹Pediatrics, Emory University School of Medicine, Atlanta, GA, ²Surgery, Emory University School of Medicine, Atlanta, GA
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). However, mouse models…
2019 American Transplant Congress
Clonal Composition And Single-cell Characterization Of T-cell Infiltrates In Cardiac Allograft Vasculopathy
M. V. Habal¹, A. Myung², H. Yan², S. Rao², S. Lin², S. See², P. Roy², R. Shihab², C. Marboe³, S. Restaino¹, A. Han², M. Givertz⁴, J. C. Madsen⁵, L. Addonizio¹, M. Farr¹, E. Zorn²
¹Cardiology, Columbia University Medical Center, New York, NY, ²Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, ³Pathology, Columbia University Medical Center, New York, NY, ⁴Cardiology, Brigham and Women's Hospital, Boston, MA, ⁵Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: T-cells are implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), yet their clonal composition and function are incompletely defined. We examined the T-cell…
2019 American Transplant Congress
JAK Inhibitor as a Novel Conditioning Approach to Establish Mixed Chimerism and Prevent Type 1 Diabetes Nonmyeloablatively
H. Xu¹, A. Merchak¹, J. Xu², Y. Huang¹, S. T. Ildstad¹
¹University of Louisville, Institute for Cellular Therapeutics, Louisville, KY, ²DuPont Manual High School, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disease that results in the destruction of islet β cells. T1D has been found to be associated…
2019 American Transplant Congress
Mechanical Irritation in Vascularized Tissue Allotransplantation Triggers Localized Skin Rejection
F. Messner, A. Fischer, E. Runggaldier, S. Eiter, B. Zelger, B. Zelger, S. Sprung, D. Öfner, S. Schneeberger, T. Hautz
Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria
*Purpose: “Atypical” forms of skin rejection have been described in some hand transplanted patients mainly manifesting on the palm including dryness, scaling and thickening of…
2019 American Transplant Congress
Immunosuppression after Organ Transplantation Does Not Enhance Patency of Cold-Stored Vein Allografts for Critical Limb Ischemia -Single Centre Experience
J. Chlupac, T. Marada, R. Novotny, K. Lipar, L. Janousek, J. Fronek
Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
*Purpose: Sub-inguinal bypass with cold-stored saphenous vein allograft is a last option treatment for extensive peripheral arterial occlusive disease with absent autologous vein. The aim…
2019 American Transplant Congress
Randomized Controlled Trial Of Spironolactone Effect In Kidney Transplant Recipients Of Living Donors
N. A. Bobadilla¹, L. E. Morales-Buenrostro¹, J. A. Ortega-Trejo¹, R. Perez-Villalva¹, L. Marino¹, Y. González-Bobadilla¹, H. Juarez¹, F. Zamora-Mejía¹, N. Gonzalez¹, R. Espinoza², J. Barrera-Chimal³
¹Nephrology, INCMNSZ, Mexico City, Mexico, ²Nephrology, Centro Médico Nacional Siglo XXI, Mexico City, Mexico, ³Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico
*Purpose: Mineralocorticoid receptor antagonism prevents acute kidney injury induced by ischemia/reperfusion in rodent and pig preclinical models. In a pilot study, we showed that spironolactone…
2019 American Transplant Congress
CD38 Inhibition: A Novel Target for Hepatic Ischemia Reperfusion Injury
C. Akateh¹, B. F. Reader¹, Y. Lee¹, J. Kim¹, K. Maynard¹, K. W. Washburn¹, J. L. Zweier², B. A. Whitson¹, S. M. Black¹
¹Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, ²The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Ischemia/reperfusion injury (IRI) is a major source of injury during many surgical procedures on the liver, and severe IRI can lead to post-hepatectomy liver…