Am J Transplant, Volume 19, Suppl 3 Archives - Page 132 of 214 - ATC Abstracts

2019 American Transplant Congress
Cluster Analysis of Microvascular Inflammation in Indication Biopsies Unveils Distinct Pathological and Immunological Phenotypes with Prognostic Implications
J. Malheiro¹, A. Silva¹, S. Santos¹, S. Tafulo², L. Martins¹, L. Dias¹, A. Castro-Henriques¹
¹Centro Hospitalar do Porto, Porto, Portugal, ²IPST_Porto, Porto, Portugal
*Purpose: We aimed to define distinct pathological and immunological clusters of 80 cases of MVI diagnosed in indication biopsies and evaluate their prognostic implications.*Methods: The…
2019 American Transplant Congress
Peri-Operative Basiliximab is Not Associated with Post-Transplant Hepatocellular Carcinoma Recurrence in Liver Transplant Recipients
D. Salerno¹, N. Lange¹, E. Simoneau², C. Sammons³, D. Bley¹, R. S. Brown Jr⁴, J. Emond², K. Halazun⁵
¹Pharmacy, NewYork-Presbyterian Hospital, New York, NY, ²Surgery, Columbia University Irving Medical Center, New York, NY, ³Pharmacy, Hospital of the University of Pennsylvania, Philadelphia, PA, ⁴Medicine, Weill Cornell Medicine, New York, NY, ⁵Surgery, Weill Cornell Medicine, New York, NY
*Purpose: The optimal immunosuppression for liver transplant recipients (LTR) with hepatocellular carcinoma (HCC) is unknown. Basiliximab, an interleukin-2 receptor antagonist (IL-2RA), confers immunosuppression for LTR…
2019 American Transplant Congress
Fatal Graft versus Host Disease in Liver Transplantation. An Analysis of UNOS Registry
S. Nagai¹, A. Yoshida¹, R. Salgia², M. Abouljoud¹, D. Moonka²
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI, ²Gastroenterology, Henry Ford Hospital, Detroit, MI
*Purpose: Graft-versus-host disease (GVHD) after liver transplant is a rare complication. This study aimed to analyze the UNOS registry to identify risk factors for fatal…
2019 American Transplant Congress
A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Lymphocyte Biology and Transplant Immunity
L. Qiu¹, J. Wang², R. Fernandez³, X. Yeap¹, S. Han¹, F. Zheng¹, C. Lin², Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Department of Surgery, Northwestern University, Chicago, IL
*Purpose: Spleen-derived lymphocytes and myeloid cell populations are critical to the development of organ transplant ischemia-reperfusion injury (IRI) and allograft rejection. In this study, we…
2019 American Transplant Congress
The Adapter Protein TSAd Regulates Mitochondrial Lck Activity and is Potent to Enhance Immunoregulation Following Transplantation
J. Wedel¹, M. P. Stack¹, T. Seto¹, K. Liu¹, I. E. Stillman², D. M. Briscoe¹
¹Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, ²Department of Pathology, Beth Israel Deaconess Center, Harvard Medical School, Boston, MA
*Purpose: T cell Specific Adaptor Protein (TSAd, encoded by the SH2D2A gene) is an intracellular adapter molecule that binds Lck and functions to elicit T…
2019 American Transplant Congress
Timing Matters: Improving Prediction of Hospital Readmission Post Kidney Transplantation
J. Hogan¹, M. Arenson¹, S. Adhikary², K. Li¹, X. Zhang¹, R. Zhang¹, J. Valdez³, J. Sun³, A. B. Adams¹, R. E. Patzer¹
¹Transplant Research Center, Department of Surgery, Emory University, Atlanta, GA, ²Transplant Research Center, Department of Surgery, Georgia Technology Institute, Atlanta, GA, ³Georgia Technology Institute, Atlanta, GA
*Purpose: Hospital readmission rates after kidney transplant (KTx) are high and readmission is associated with graft failure and mortality. Predictive models of post-transplant readmission have…
2019 American Transplant Congress
Barriers to Listing for Kidney Transplantation in LMICs: A Single Center Retrospective Cohort Study in Brazil
Y. Yu¹, G. Ferreira², A. Saha¹, M. Henderson¹, D. Segev¹, J. Bastos², V. Colares², A. Massie¹
¹Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, ²Santa Casa de Misericordia de Juiz de Fora, Juiz de Fora, Brazil
*Purpose: Incidence of end-stage renal disease (ESRD) is increasing in low- and middle-income countries (LMICs), but citizens of LMICs face barriers to transplantation that are…
2019 American Transplant Congress
Safety and Efficacy of Anti Xa Inhibitors Post-Transplant with Concomitant Calcineurin Inhibitors
K. A. McMurry¹, J. Shuster², K. Bain², T. Horwedel³, J. Hartupee²
¹Michigan Medicine, Ann Arbor, MI, ²Barnes-Jewish Hospital, St. Louis, MO, ³Veloxis Pharmaceuticals, Cary, NC
*Purpose: Despite demonstrated benefits of Anti-Xa Inhibitors (ATIs) in the general population, ATIs have not gained uniform acceptance in SOT due to lack of supportive…
2019 American Transplant Congress
A Collaborative AI Framework to Improve the MELD Exception Request Policy Process
A. M. Placona, S. M. Noreen, R. Carrico
Research, United Network for Organ Sharing, Henrico, VA
*Purpose: A goal of organ allocation policy is to balance medical urgency with equitable access to transplant. MELD Exceptions attempt to ensure that patients’ medical…
2019 American Transplant Congress
Listing Practices and Graft Utilization Lag behind Supply of Hepatitis C Positive Deceased Donors for Liver and Kidney Transplant
C. E. Kling¹, J. D. Perkins², S. W. Biggins³, C. Johnson⁴, A. P. Limaye⁵, L. Sibulesky¹
¹Division of Transplant Surgery, University of Washington Medical Center, Seattle, WA, ²Division of Transplant Surgery and Clinical and Bio-Analytics Transplant Laboratory, University of Washington Medical Center, Seattle, WA, ³Divisions of Gastroenterology and Hepatology and Center for Liver Investigation Fostering DiscovEry, University of Washington Medical Center, Seattle, WA, ⁴Division of Nephrology, University of Washington Medical Center, Seattle, WA, ⁵Division of Infectious Disease, University of Washington Medical Center, Seattle, WA
*Purpose: The opioid epidemic resulted in increasing incidence of hepatitis C (HCV) in the general population and more deceased organ donors with HCV in the…