Am J Transplant, Volume 19, Suppl 3 Archives - Page 132 of 214 - ATC Abstracts

2019 American Transplant Congress
Exosomes Isolated from Human Lung Transplant Recipients Diagnosed with Bronchiolitis obliterans Syndrome are Unique in Their Ability to Induce IL-6 via Rab27A Signaling Pathway
M. Rahman, M. Sharma, S. Angara, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Rab27, a member of the Rab subfamily of GTPases, has the ability to induce exosome secretion. Exosomes are small membrane vesicles (40-150nm) that regulate…
2019 American Transplant Congress
IgG Glycosylation Causes Podocyte Injury in Transplant Glomerulopathy through Calcium Calmodulin Kinase IV
R. Bhargava, K. Maeda, M. Pavlakis, G. Tsokos
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
*Purpose: Transplant glomerulopathy(TG) is a major cause of late allograft loss. Increase in urine podocin/creatinine ratio in TG signifies acceleration of podocyte detachment from glomerular…
2019 American Transplant Congress
Kidney Allograft Recipient Absence of Myeloperoxidase Decreases Donor-Specific Antibody Titers and Attenuates Antibody-Mediated Allograft Rejection
S. Miyairi, N. Dvorina, A. Valujuskikh, W. M. Baldwin 3rd, R. L. Fairchild
Immunology, Cleveland Clinic Lerner Institute, Cleveland, OH
*Purpose: The incidence of antibody-mediated kidney graft rejection continues to increase. We previously reported that dysregulated donor-specific antibody (DSA) responses were induced in B6.CCR5-/- mice…
2019 American Transplant Congress
Stem Cell and Granulocyte- Colony Stimulating Factor Therapies to Improve Functional Outcomes in Limb Transplantation
J. Weiss¹, C. Phillips¹, E. Malin¹, V. Gorantla², S. K. Salgar³
¹Surgery, Madigan Army Medical Center, Tacoma, WA, ²Surgery, Wake Forest University, Salem, NC, ³Clinical Investigation, Madigan Army Medical Center, Tacoma, WA
*Purpose: Although, over 200 clinical Vascularized Composite Allotransplantation (VCA) such as hands, legs, and face have been performed worldwide, still there are many challenges such…
2019 American Transplant Congress
Achieving Robust Targeting of Antibody-Conjugated Nanoparticles Delivered during Ex Vivo Machine Perfusion of Human Kidneys
J. R. DiRito¹, S. Hosgood¹, M. L. Nicholson¹, G. Tietjen²
¹Surgery, University of Cambridge, Cambridge, United Kingdom, ²Surgery, Yale School of Medicine, New Haven, CT
*Purpose: In this study we seek to improve targeted nanoparticle (NP) delivery during ex-vivo normothermic machine perfusion through fibrinolysis for more homogenous treatment of human…
2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
S. Lan¹, B. Yang¹, M. Dieudé¹, J. Sabo-Vatasescu², A. Karakeussian-Rimbaud², J. Turgeon², S. Qi³, N. Patey⁴, M. Hébert¹
¹Medicine Faculty, CRCHUM, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³Department of Surgery, CRCHUM, University of Montreal, Montreal, QC, Canada, ⁴Department of Pathology and Cell Biology, CHU Saint-Justine, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…
2019 American Transplant Congress
Distinct Delayed Classical Complement Pathway Activation Highlights Transition of Ischemic Acute Kidney Injury to Chronic Kidney Disease with Interstitial Fibrosis/Tubular Atrophy
S. Kumar, S. Jordan
Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Ischemia reperfusion Injury (IRI)-induced AKI of the renal allograft frequently leads to delayed graft function (DGF). Patients with DGF suffer from prolonged hospitalization with…
2019 American Transplant Congress
Parathyroid CD34+ Cells Induce Neovascularization of Donor and Recipient Leading to Chimeric Vessel Formation and Improved Engraftment of Co-Transplanted Pancreatic Islets
Y. Kelly¹, C. Ward¹, Q. Duh¹, W. Chang², P. Stock¹, Q. Tang¹
¹UCSF, San Francisco, CA, ²San Francisco Veterans Affairs, San Francisco, CA
*Purpose: We recently showed improved engraftment and diabetes reversal when mature islets or stem-cell-derived beta cells (SCIPC) were co-transplanted with parathyroid gland (PTG). The CD34+…
2019 American Transplant Congress
Whole-Exome Sequencing Identifies PMS1 and DYRK1A Genes Contributing to Occurrence of Liver Cancer
Y. Zhao, B. Yang, D. Chen, L. Wei, Z. Chen
Tongji hospital, Huazhong university, Organ Transplantation, Wuhan, China
*Purpose: Liver cancer is one of the most frequent cancers in China and the accurate landscape of liver cancer, especially of HBV-infected liver cancer in…
2019 American Transplant Congress
Impact of IgG Subclass and C1q Binding Donor-Specific HLA Antibodies on Antibody Mediated Rejection in Kidney Transplant Recipients
H. Lee¹, J. Ryu¹, S. Yun¹, T. Ban², E. Ko², C. Yang², E. Oh¹
¹Department of Laboratory Medicine, The Catholic University of Korea, Seoul, Korea, Republic of, ²Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: Donor specific HLA antibody (DSA) is a leading cause of antibody mediated rejection (AMR) and graft loss in kidney transplants. It is known that…