Am J Transplant, Volume 19, Suppl 3 Archives - Page 126 of 214 - ATC Abstracts

2019 American Transplant Congress
Standardizing Blood Pressure Measurement across 17 Pediatric Transplant Centers: The Improving Renal Outcomes Collaborative
M. E. Seifert¹, R. Garro², R. P. George², G. Barletta³, C. W. Belsha⁴, A. Chaudhuri⁵, J. W. Goebel⁶, L. Wickman⁷, D. Matossian⁸, J. Misurac⁹, C. Nailescu¹⁰, C. R. Nguyen¹¹, M. Pearl¹², A. Pollack¹³, C. S. Pruette¹⁴, P. Singer¹⁵, P. S. Verghese¹⁶, B. A. Warady¹⁷, D. S. Dahale¹⁸, D. K. Hooper¹⁸
¹University of Alabama, Birmingham, AL, ²Emory University, Atlanta, GA, ³Phoenix Children's Hospital, Phoenix, AZ, ⁴Saint Louis University, St. Louis, MO, ⁵Stanford University, Stanford, CA, ⁶Children's Hospital Colorado, Aurora, CO, ⁷Michigan Medicine, Ann Arbor, MI, ⁸Lurie Children's Hospital, Chicago, IL, ⁹University of Iowa, Iowa City, IA, ¹⁰Riley Hospital For Children, Indianapolis, IN, ¹¹Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ¹²UCLA Mattel Children’s Hospital, Los Angeles, CA, ¹³Seattle Children's Hospital, Seattle, WA, ¹⁴Johns Hopkins University, Baltimore, MD, ¹⁵Cohen Children's Medical Center, New Hyde Park, NY, ¹⁶University of Minnesota, Minneapolis, MN, ¹⁷Children's Mercy Kansas City, Kansas City, MO, ¹⁸Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: We report efforts from the Improving Renal Outcomes Collaborative (IROC) to standardize appropriate BP measurement across 17 pediatric kidney transplant centers.*Methods: 17 centers participated…
2019 American Transplant Congress
Advanced Immunological T-cell Ageing Defined by a Very Low Thymic Function Identifies Patients with a Substantial Increased Risk for Long-Term Mortality after Kidney Transplantation
M. G. Betjes, A. Langerak, M. Klepper, N. Litjens
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: End-stage renal disease is associated with premature ageing of the T-cell immune system. At the time of kidney transplantation the average biological age of…
2019 American Transplant Congress
A Kidney Transplant Recipient with Severe Acute GvHD Promptly Rescued by Donor HLA-Targeted Serotherapy
J. Zuber¹, O. Boyer¹, B. Neven¹, R. Berthaud¹, M. Ould Rabah¹, I. Jollet², V. Renac², F. Pirenne², S. Gross², R. Djoudi², P. Tiberghien², J. Taupin³, S. Blanche¹, R. Salomon¹
¹Paris Descartes University, Paris, France, ²Etablissement Français du Sang, Paris, France, ³Department of Immunology and Histocompatibility, St Louis Hospital, Paris, France
*Purpose: Acute Graft-versus-Host Disease (GvHD) is a rare but frequently lethal complication after solid organ transplantation (SOT). In intestinal transplant recipients, anti-HLA Donor-Specific Antibody (DSA)…
2019 American Transplant Congress
Impact of Liver Recipient Genotype on Tacrolimus
S. Tremblay¹, T. Fukuda², T. Mizuno², A. A. Vinks², E. Woodle¹, J. Klawitter³, J. Klawitter³, U. Christians³, R. R. Alloway¹
¹University of Cincinnati, Cincinnati, OH, ²Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ³iC42 Clinical Research and Development, Aurora, CO
*Purpose: In kidney transplant recipients, recipient genotype (CYP3A5 *3) has the greatest influence on tacrolimus pharmacokinetics (PK). However, in liver transplant recipient, donor liver and…
2019 American Transplant Congress
Galectin-3 and Long-Term Graft Failure in Renal Transplant Recipients: A Prospective Cohort Study
C. G. Sotomayor¹, C. A. Keyzer¹, J. L. Anderson¹, R. O. Gans², I. M. Nolte³, M. H. de Borst¹, S. P. Berger¹, G. J. Navis¹, R. A. de Boer⁴, S. J. Bakker¹
¹Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands, ²Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands, ³Department of Epidemiology, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Cardiology, University Medical Center Groningen, Groningen, Netherlands
*Purpose: Galectin-3 has been associated with renal fibrosis and decline of renal function. We aimed to determine the association of galectin-3 with long-term risk of…
2019 American Transplant Congress
IL-6R Blockade with Tocilizumab Increases Tregs and Decreases Early Graft Inflammation in Kidney Transplant Recipients: Results of a Randomized Controlled Trial
S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Joanes, F. Vincenti
UCSF, San Francisco, CA
*Purpose: IL-6, a proinflammatory cytokine and key regulator of Treg/Th17 balance, is strongly associated with renal graft rejection. We hypothesized that IL-6 blockade with tocilizumab…
2019 American Transplant Congress
The Risk of Systematic Error in Kidney Transplant Opioid Research
J. N. Fleming, N. A. Pilch, S. Ball, P. K. Baliga, V. Rohan, D. J. Taber
Medical University of South Carolina, Charleston, SC
*Purpose: Opioid use before and after kidney transplant is strongly associated with morbidity and mortality; yet data assessing opioid utilization has centered on sources with…
2019 American Transplant Congress
Adult Living Donor vs. Deceased Donor Liver Transplant (LDLT vs. DDLT) at a Single US Center- Time to Change Our Paradigm for Liver Transplant
A. Humar, D. Jorgensen, S. Ganesh, A. Tevar, M. Molinari, C. Hughes
Thomas E Starzl Transplant Inst, Pittsburgh, PA
*Purpose: LDLT remains underutilized in the US. We compared outcomes between LDLT and DDLT at our center to highlight the advantages of LDLT.*Methods: Retrospective review…
2019 American Transplant Congress
Improving Access to Lung Transplant through Donor Strategy: A Decision Analysis
W. Tsuang, B. Udeh
Cleveland Clinic, Cleveland, OH
*Purpose: The use of Donation after Cardiac Death (DCD) donors in addition to Donation after Brain Death (DBD) donors may increase patient access to lung…
2019 American Transplant Congress
Platelets Augment Granzyme K Production By Macrophages In Antibody-mediated Rejection
J. Dhar, K. Keslar, R. Fan, N. Dvorina, W. Baldwin
Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: When antibodies bind to MHC antigens on endothelial cells a cascade of responses is initiated including exocytosis of adhesion molecules followed by attachment and…