2019 American Transplant Congress
Post-Transplant Cancer Following Living Donor HLA-Incompatible Kidney Transplantation
1Johns Hopkins University, Baltimore, MD, 2University of Alabama, Birmingham, AL
*Purpose: Incompatible living donor kidney transplantation (ILDKT) recipients require increased immunosuppression compared to their compatible living donor kidney transplant (CLDKT) counterparts. This continued exposure to…2019 American Transplant Congress
Retrospective Nested Case Control Study of the Impact of Immunosuppression on Post Transplant Malignancy among Adult Heart Transplant Patients
*Purpose: Post-transplant malignancy is diagnosed in approximately 18% of heart transplant (HTx) recipients and is a leading long-term cause of death among these patients. The…2019 American Transplant Congress
Transplantation of Hepatitis C Virus Positive Donor Kidneys into Hepatitis C Negative Older Recipients
*Purpose: Patients awaiting transplantation are often at risk of developing life-threatening disease and complications. Older patients have a disproportionately higher risk of dropping out of…2019 American Transplant Congress
Blood Profiling Reflects a Significant Down-Regulation in Oxidative Phosphorylation Following Renal Transplantation with DCD and AKI Allografts
*Purpose: The human kidney transplant (KT) patient provides a unique and compelling in situ model system to study molecular events that underlie graft recovery following…2019 American Transplant Congress
Perioperative Blood Transfusion Significantly Increases Inpatient Morbidity and Mortality in Renal Transplant Recipients: 15-year Experience
*Purpose: This study evaluates the immediate effects of perioperative blood transfusion (PBT) on inpatient morbidity and mortality among renal transplant (RT) recipients during their index…2019 American Transplant Congress
Barriers to Pre-Transplant Immunization: A Qualitative Study of Pediatric Liver-Transplant Stakeholders
*Purpose: Less than 30% of pediatric liver transplant recipients are up-to-date on age-appropriate immunizations at the time of transplant despite being at high-risk for infections…2019 American Transplant Congress
Ablation of Interferon Regulatory Factor 4 in T Cells Induces “Memory” of Transplant Tolerance That is Irreversible by Immune Checkpoint Blockade
*Purpose: Achieving alloantigen-specific transplant tolerance through ablation of interferon regulatory factor 4 in T cells*Methods: 1. Irf4fl/flCD4-Cre recipients were first transplanted with BALB/c hearts and…2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…2019 American Transplant Congress
Population-Based Modeling of Prototypes and Determinants of Allograft Function Trajectories after Kidney Transplantation: Impact for Patient Monitoring and Risk Stratification
*Purpose: Although the current gold standard of kidney allograft patients monitoring relies on GFR assessment, little is known about long-term GFR trajectories prototypes and their…
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