Am J Transplant, Volume 19, Suppl 3 Archives - Page 111 of 214 - ATC Abstracts

2019 American Transplant Congress
Epidemiology and Outcomes of BKV Nephropathy Management by Screening Policy in a Real-Life Setting
V. D. GARCIA¹, F. V. Raupp¹, G. MEINERZ¹, K. Piegas², E. KEITEL¹
¹Nephrology and Kidney and Pancreas Transplant Department, ISCMPA, Porto Alegre, Brazil, ²Pathology Department, ISCMPA, Porto Alegre, Brazil
*Purpose: To verify the frequency of BKVAN in a single center's clinical setting and evaluate the response to immunosuppressive adjustments through graft survival analysis.*Methods: Retrospective…
2019 American Transplant Congress
Assessing Pressure to Donate among Potential Living Kidney Donors
D. R. Helfer¹, J. Stanton², E. A. King¹, A. K. Eno¹, J. M. Ruck¹, A. A. Shaffer¹, A. G. Thomas¹, M. M. Waldram¹, A. M. Cameron¹, J. Kahn¹, L. Erby¹, M. L. Henderson¹, D. L. Segev¹, J. M. Garonzik Wang¹
¹Johns Hopkins University, Baltimore, MD, ²East Carolina University, Greenville, NC
*Purpose: In the setting of ongoing methods to increase living donation, including novel methods that harness the power of social media, it is imperative that…
2019 American Transplant Congress
Basiliximab versus T-cell Depleting Induction Therapy in Elderly Kidney Transplant Recipients
G. Vranic, H. Shah, B. Thomas, B. Javaid, J. Moore, M. Cooper, A. Gilbert
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: The ideal induction therapy for elderly kidney transplant recipients is not known. Given concerns about increased risk of infection and malignancy and perceived decreased…
2019 American Transplant Congress
Circulating Donor T and NK Cells in Lung Transplantation Recipients Are Derived from the Donor Lung Parenchyma and Represent Tissue-Resident Memory Cells
J. F. Kuehne¹, R. Ballmàs Sanz¹, A. Hitz¹, B. Wiegmann², K. A. Bläsing¹, F. Ius², A. Knoefel², I. Tudorache², M. Avsar², D. Jonigk³, A. Haverich², G. Warnecke², C. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School (MHH), Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School (MHH), Hannover, Germany, ³Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany
*Purpose: We previously identified donor lymphocytes in peripheral blood of recipients directly after transplantation and persisting at least three weeks that were characterized by the…
2019 American Transplant Congress
Lineage Tracing Identifies C-Kit Cells as a Population of Kidney-Specific Stem Cells during Development and in Acute and Chronic Kidney Diseases
E. B. Rangel¹, E. Higuti-Sousa¹, G. Goss², B. Goldstein², B. Seidler³, D. Saur³, S. A Gomes⁴, J. M. Hare²
¹Albert Einstein Hospital, São Paulo, Brazil, ²University of Miami, Miami, FL, ³Medizinische Klinik, Technische Universität München, Munich, Germany, ⁴University of São Paulo, São Paulo, Brazil
*Purpose: We recently reported that c-Kit cells isolated from developing kidneys exhibit regenerative potential in mouse models of acute nephrotic syndrome and ischemia-reperfusion injury. These…
2019 American Transplant Congress
Using Liver Transplant (LT) Data And Analytics to Improve Program Clinical and Financial Performance
A. Bonham¹, Z. Tulu², W. Concepcion¹, A. Gallo¹, M. Melcher¹, P. Kwo¹, A. Ahmed¹, C. Esquivel¹
¹Stanford University Medical School, Palo Alto, CA, ²Stanford Health Care, Palo Alto, CA
*Purpose: In 2017, we developed a simple algorithm for use prior to transplantation to determine risk of fatal outcome. Pre-transplant organ system failure risk factors…
2019 American Transplant Congress
Donate HCV Trial: Transplanting Thoracic Organs from Hepatitis C Donors to Uninfected Patients
A. E. Woolley¹, S. K. Singh², H. J. Goldberg³, M. M. Givertz⁴, M. R. Mehra⁴, A. Coppolino, III⁵, V. Cheng¹, J. Fanikos⁶, D. P. Harrington⁷, H. R. Mallidi², L. R. Baden¹
¹Infectious Diseases, Brigham and Womens Hospital, Boston, MA, ²Cardiac and Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ³Pulmonary, Brigham and Womens Hospital, Boston, MA, ⁴Cardiology, Brigham and Womens Hospital, Boston, MA, ⁵Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ⁶Pharmacy, Brigham and Womens Hospital, Boston, MA, ⁷Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: Given the need for thoracic organs and the high mortality of patients awaiting heart or lung transplantation, it is imperative to find ways to…
2019 American Transplant Congress
Single Cell RNA-seq Analysis of Antibody-Mediated Rejection Reveals Endothelial – Pericyte NOTCH Signaling
A. F. Malone, A. Chadha, H. Wu, S. Ramakrishnan, E. Donnelly, B. D. Humphreys
Washington University School of Medicine, Saint Louis, MO
*Purpose: To precisely define endothelial cell responses in AMR we performed comprehensive single cell RNA-seq on a human kidney biopsy with AMR.*Methods: Single cell libraries…
2019 American Transplant Congress
Promoting Mitochondrial Fusion Alters the Interaction between Endothelial Cells and T Cells in Models of Transplantation
D. T. Tran, C. Atkinson, S. N. Nadig
Medical University of South Carolina, Charleston, SC
*Purpose: As semi-professional antigen-presenting cells, microvascular endothelial cells (mECs) play a central role in mediating allograft rejection. Cold storage and ischemia reperfusion injury increases mEC…
2019 American Transplant Congress
Non-HLA Antibodies against Structural and Non-Structural Target in C4d Negative Antibody Mediated Rejections after Renal Transplantation
S. Kanangat¹, I. Kurbegovic-Skaljic², D. Cimbaluk², M. Oppermann², S. Jensik³, E. Hollinger³, O. Olaitan⁴, R. DeCresce²
¹Tumor Immunology, NIH/NCI Bethesda MD,USA, Bethesda, MD, ²Pathology, Rush University Medical Center, Chicago, IL, ³Surgery, Rush University Medical Center, Chicago, IL, ⁴Tumor Immunology, Rush University Medical Center, Chicago, IL
*Purpose: According to the latest Banff’s criteria approved in 2003, antibody mediated rejections following renal transplantation are divided into 2 types namely C4d + and…