ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Dendritic Cells Transduced with Autoimmune Regulator Exhibit Immature Properties and Prolong Heart Allograft Survival

    Y. Zhang, Z. Zhu, M. Chen, S. Huang, C. Sun, W. Ju, Z. Guo, X. He

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    *Purpose: The expression of the Aire (Autoimmune regulator) gene was observed to inhibit the maturation and activation of dendritic cells (DCs) and induce transplantation tolerance.*Methods:…
  • 2019 American Transplant Congress

    Utilizing Changing Patterns of T-cell Metabolism in Aging for Effective Immunosuppression

    Y. Nian, T. Heinbokel, K. Minami, R. Maenosono, J. Iske, A. El Khal, S. G. Tullius

    Transplant Surgery Research Lab, Brigham and Women’s Hospital, Boston, MA

    *Purpose: Metabolic reprogramming has been identified as a critical regulator of immunity. Little is known on changes of T-cell metabolism in aging and how to…
  • 2019 American Transplant Congress

    Diminishing Scientific Registry of Transplant Recipients Risk-Adjusted Mortality: Reaction to Flagging, Artifact of Modeling, or Both?

    J. A. Gregg1, K. L. Womer1, A. Santos1, S. J. Moore2, K. A. Andreoni3

    1Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL, 2Shands Transplant Center, University of Florida, UF Health Shands, Gainesville, FL, 3Department of Surgery, University of Florida, Gainesville, FL

    *Purpose: To examine longitudinal trends in SRTR risk-adjusted patient and graft survival rates.*Methods: Current, and archived versions of The Scientific Registry of Transplant Recipients (SRTR)…
  • 2019 American Transplant Congress

    Preliminary Results from a Multicenter National Trial of Antiviral-Facilitated Transplantation of Hepatitis C Hearts to Expand the Donor Pool

    K. Martits-Chalangari, A. K. Doss, M. Clark, J. Felius, S. A. Hall, R. L. Gottlieb

    Baylor University Medical Center, Dallas, TX

    *Purpose: Solid organs from donors with evidence of active HCV viremia are historically underutilized particularly for HCV negative recipients. The development of easily tolerated, oral,…
  • 2019 American Transplant Congress

    Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Interstitial Fibrosis and Tubular Atrophy

    G. Gupta1, D. Kumar1, M. Raynaud2, A. Loupy2, J. Chang3, J. Reeve3, P. Sanghi1, I. Yakubu1, L. Kamal1, M. Levy1, C. Bhati1, P. Kimball1, A. King1, H. Massey1, P. Halloran3

    1Virginia Commonwealth University, Richmond, VA, 2Paris Transplant Group, Paris, France, 3Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Prior studies on the conversion of tacrolimus (Calcineurin Inhibitor; CNI) to belatacept have been limited in scope due to either the absence of, post-conversion…
  • 2019 American Transplant Congress

    More Advanced Heart Failure Prior To Transplant May Influence The Cytomegalovirus Specific T Cell Response In Cytomegalovirus Positive Recipients.

    U. López Cardoza, E. García, C. Díez, J. Roca, N. Sabé, N. Manito, I. Tatjer, A. Cequier, O. Bestard, J. González

    Bellvitge Universitary Hospital, L' Hospitalet de Llobregat, Spain

    *Purpose: Current assessment of risk of Cytomegalovirus (CMV) infection in CMV+ heart transplant (HT) recipients is poor. A diminished CMV-specific T cell response against 2…
  • 2019 American Transplant Congress

    Tocilizumab for Refractory Antibody-Mediated Rejection in Pediatric Kidney Transplantation

    A. Dokras, C. Butler, Q. Zhang, E. Reed, R. Ettenger, P. Weng, M. Pearl

    University of California, Los Angeles, Los Angeles, CA

    *Purpose: IL-6 blockade may play a role in reducing human leukocyte antigen donor specific antibodies (HLA DSA) production and stabilizing allograft function. We aimed to…
  • 2019 American Transplant Congress

    Gut Dysbiosis Predominates Post-Transplant Diarrhea in Kidney Transplant Recipients: A Validation Study

    L. Zhang, J. Lee, M. Magruder, E. Edusei, D. Dadhania, M. Lubetzky, S. Albakry, B. Botticelli, E. Pamer, M. Suthanthiran

    Weill Cornell Medicine, New York, NY

    *Purpose: Lower abundance of commensal bacterial taxa in the gut has been previously described in a recent study of kidney transplant recipients with post-transplant diarrhea…
  • 2019 American Transplant Congress

    Occult Liver Graft Fibrosis Prior to Transplantation Influences Clinical Outcomes

    H. Hirao, T. Ito, K. Kadono, S. Kageyama, K. Nakamura, K. J. Dery, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

    Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: Liver transplantation (LT) has become a standard therapy for the management of end-stage liver disease, while early allograft dysfunction (EAD) remains a serious problem.…
  • 2019 American Transplant Congress

    A Clinical Pharmacogenetic Model to Predict the Efficacy of Sirolimus during the Early Administration in Renal Transplant Recipients

    Z. Wang, S. Fei, Z. Han, J. Tao, R. Tan, M. Gu

    No.300 Guangzhou Road of Nanjing, Nanjing, China

    *Purpose: This study was to develop a clinical pharmacogenetic model to predict the efficacy of sirolimus during the early administration in renal transplant recipients. 70…
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