ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Pathologic Vascular Invasion Correlates with Worse Outcome in Hepatoblastoma Patients Treated with Liver Transplantation – A Hepatoblastoma Transplant Consortium Study

    T. H. Malik1, H. Zhu2, T. Ha3, S. Commander4, C. Trautz5, R. Sindhi5, S. Kim6, K. Vakili6, N. Vachharajani7, W. Chapman7, A. Griesemer8, M. Martinez8, J. A. Goss9, S. Vasudevan10

    1Baylor College of Medicine, Houston, TX, 2Texas Children's Hospital, Houston, TX, 3Department of Surgery, Baylor College of Medicine, Houston, TX, 4Department of Surgery, Duke University School of Medicine, Durham, NC, 5Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 6Department of Surgery, Boston Children's Hospital, Boston, MA, 7Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO, 8Department of Surgery, NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY, 9Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX, 10Department of Pediatric Surgery, Texas Children's Hospital, Houston, TX

    *Purpose: Orthotopic liver transplant (OLTx) is the most common method to treat unresectable hepatoblastoma (HB) in children. There is limited data focusing on the outcomes…
  • 2019 American Transplant Congress

    The Important Roles of Dendritic Cells in Transplantation

    T. Ueno1, M. M. McGrath1, M. Y. Yeung1, S. Cai1, Y. Ueno1, T. Yokoyama2, Y. Kihara2, O. Konno2, Y. Nakamura2, H. Iwamoto2, A. K. Chandraker1

    1Medicine, Renal Division, Brigham and Women's Hospital, Transplantation Research Center, Boston, MA, 2Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan

    *Purpose: The interplay between dendritic cells (DCs) and T cells plays a central role in the process of allograft rejection. Upon antigen exposure, positive costimulatory…
  • 2019 American Transplant Congress

    Full and Sustained Donor Hematopoietic Chimerism after an Isolated Kidney Transplantation

    J. Zuber1, O. Boyer1, B. Neven1, E. Six2, R. Berthaud1, M. Ould Rabah1, S. Sobrino2, C. Lagresle2, I. André-Schmutz2, M. Cavazzana1, S. Blanche1, R. Salomon1

    1Paris Descartes University, Paris, France, 2Inserm UMRS 1163, Paris, France

    *Purpose: Full donor chimerism was reported three times in the absence of myelosuppressive regimen, only after liver or multivisceral transplantation, but never after kidney transplantation.…
  • 2019 American Transplant Congress

    Increased Frequency of Myeloid-Derived Suppressor Cells Contributing to Prolong Skin Allograft Survival in Aged Mice

    W. Lee, Y. Wang, T. Wu, C. Cheng, C. Lee, T. Wu, H. Chou, K. Chan

    General Surgery, Chang-gung Hospital, Taoyuan, Taiwan

    *Purpose: Currently, aged people are increasing and more and more aged people have organ transplantation. The immunity in aged people is weaker than young people.…
  • 2019 American Transplant Congress

    Generation of Human/Pig Hybrid Thymus to Achieve Immune Tolerance to Pig Antigens with Optimal Immune Function

    M. Khosravi Maharlooei, H. Li, M. Holzl, A. Vecchione, A. Misra, A. Ruiz, R. Madley, G. Nauman, N. Danzl, G. Zhao, K. Yamada, M. Sykes

    Columbia University, New York, NY

    *Purpose: Thymus transplantation is a promising approach to induce T-cell tolerance for xenotransplantation. We have previously shown that humanized mice generated with human hematopoietic stem…
  • 2019 American Transplant Congress

    De Novo Complement-Activating Donor Specific Antibodies in Pediatric Renal Transplant Recipients Are Highly Responsive to Therapy

    V. Sigurjonsdottir, A. Chaudhuri, P. Grimm

    Pediatric Nephrology, Stanford, Los Altos, CA

    *Purpose: Antibody mediated rejection remains a common cause for pediatric renal allograft loss. After recognizing that graft failure was more common in our pediatric renal…
  • 2019 American Transplant Congress

    Regional Disparities In The Transplant Rates Across Unos Regions Pre- And Post-kidney Allocation System Policy Implementation

    A. C. Perez-Ortiz, E. Heher, N. Elias

    Massachusetts General Hospital, Boston, MA

    *Purpose: Geographic distribution of organs for transplant is a critical component of the Organ Procurement and Transplantation Network (OPTN) policies. However, there is no single…
  • 2019 American Transplant Congress

    Safety and Efficacy of Imlifidase in Highly-Sensitized Kidney Transplant Patients: Results from a Phase 2 Study

    S. C. Jordan1, C. Legendre2, N. Desai3, T. Lorant4, M. Bengtsson4, L. Laxmyr5, B. Lonze6, A. Vo1, K. J. Wood7, C. Kjellman5, R. A. Montgomery6

    1Cedars-Sinai Medical Center, Los Angeles, CA, 2Hopital Necker, Paris, France, 3Johns Hopkins University, Baltimore, MD, 4Uppsala University, Uppsala, Sweden, 5Hansa Medical AB, Lund, Sweden, 6NYU Langone Health Transplant Institute, New York, NY, 7University of Oxford, Oxford, United Kingdom

    *Purpose: Many patients eligible for kidney transplantation are sensitized to allo-HLA antigens and face prolonged waiting times and increased mortality. The presence of donor specific…
  • 2019 American Transplant Congress

    Early Tacrolimus Trough Concentration Variability Could Predict Rejection in Pediatric Liver Transplantation: A Single-Center and Retrospective Research

    G. Gu, Q. Xia

    Renji Hospital, Shanghai, China

    *Purpose: With great development in immunosuppressive therapy, the long-term outcomes and survival time in patients who received solid organ transplantation have been improved remarkably. The…
  • 2019 American Transplant Congress

    Endothelial Cell Replacement – A Closer Step to Personalized, Tissue-Engineered Transplants

    S. Cohen, S. Partouche, M. Gurevich, V. Mezhybovsky, V. Tennak, S. Eisner, E. Nesher, E. Mor

    Rabin Medical Center, Petah-Tiqwa, Israel

    *Purpose: Whole organ perfusion decellularization has been proposed as a promising method for the generation of non-immunogenic organs from allogeneic or xenogeneic donors. However, the…
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