Am J Transplant, Volume 19, Suppl 3 Archives - Page 100 of 214 - ATC Abstracts

2019 American Transplant Congress
Generation of Thymic Epithelial Cells from Induced Pluripotent Stem Cells to Prolong Allograft Survival
R. Otsuka, H. Wada, H. Tsuji, A. Sasaki, T. Murata, M. Baghdadi, K. Seino
Institute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
*Purpose: Pluripotent stem cell (PSC) is a potential source of generating functional therapeutic cells for transplantation. Embryonic stem cells are of absolutely allogeneic origin. Induced…
2019 American Transplant Congress
Tolerance to ABO A-Antigen Following Treatment of Infant Mice with A-Expressing MHC-Identical Erythrocytes
B. Motyka¹, J. Fersovich¹, M. Sulzer¹, I. Adam¹, J. Pearcey¹, K. Tao¹, C. W. Cairo², P. J. Cowan³, L. J. West¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian Donation and Transplant Research Program, University of Alberta, Edmonton, AB, Canada, ²Department of Chemistry, University of Alberta, Edmonton, AB, Canada, ³Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia
*Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe in young children and increases donor access. Post-ABOi HTx, B cell tolerance develops to donor ABO blood…
2019 American Transplant Congress
Indicators of Impending Pig Organ Xenograft Failure: Relevance to Clinical Xenotransplantation
H. Iwase¹, A. Jagdale¹, T. Yamamoto¹, G. Zhang¹, Q. Li¹, J. Foote¹, D. Ayares², H. Hara¹, D. K. Cooper¹
¹University of Alabama at Birmingham, Birmingham, AL, ²Revivicor, Inc., Blacksburg, VA
*Purpose: In pig-to-baboon organ xenotransplantation, coagulation dysfunction and inflammation have been suggested to be associated with acute humoral xenograft rejection. We have evaluated platelet counts,…
2019 American Transplant Congress
Role of Innate Allorecognition Pathways in Mouse Renal Allograft Rejection
D. Zhao¹, H. Dai¹, K. Abou-Daya¹, A. Williams¹, M. Oberbarnscheidt¹, X. Li², F. Lakkis¹
¹Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ²Houston Methodist Hospital Immunobiology & Transplant Science Center, Houston, TX
*Purpose: Allograft rejection is initiated by host immune system distinguishing between self and allogeneic non-self (allorecognition). Paired immunoglobulin-like receptor (PIR) and CD47 are molecules expressed…
2019 American Transplant Congress
Longer-Term Outcomes for Hepatitis C Virus Negative Recipients of Kidneys from Hepatitis C Virus Nucleic Acid Test Positive Donors: The THINKER Trial
P. Reese¹, P. Abt¹, E. Blumberg¹, R. Bloom¹, D. Sawinski¹, P. Porrett¹, A. Woodards¹, K. Reddy¹, V. van Deerlin¹, R. Hasz², M. Levine¹, R. McLean¹, A. Sicilia¹, D. Goldberg¹
¹University of Penn, Philadelphia, PA, ²Gift of Life, Philadelphia, PA
*Purpose: Two trials of transplanting hepatitis C virus (HCV) nucleic acid test (NAT) positive kidneys into HCV-negative recipients have been published, both with 100% HCV…
2019 American Transplant Congress
Robotic-Assisted versus Open Techniques for Living Donor Kidney Transplant Recipients: A Comparison Using Propensity Score Analysis
F. Tinney, J. Stracke, S. Nagai, L. Malinzak, T. McEvoy, S. Mohamed Ilias, A. Yoshida
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: Following rapid advancements in minimally invasive urology, living donor robotic-assisted kidney transplantation (RAKT) has developed into a feasible alternative to open kidney transplantation (OKT).…
2019 American Transplant Congress
Lower Rates of Epstein-Barr Virus Viremia and Post-Transplant Lymphoproliferative Disease in Pediatric Solid Organ Transplant Recipients Who Received Valganciclovir Prophylaxis
E. A. Moulton¹, M. Karandikar², S. Bond³, S. Burchett², T. Sharma², F. M. Marty³
¹Baylor College of Medicine, Houston, TX, ²Boston Children's Hospital, Boston, MA, ³Brigham and Women's Hospital, Boston, MA
*Purpose: Antiviral prophylaxis to prevent post-transplant lymphoproliferative disease (PTLD) remains controversial, but some data suggest that valganciclovir or ganciclovir use in Epstein-Barr virus (EBV) high-risk…
2019 American Transplant Congress
Evaluating Liver Regeneration during Normothermic Machine Perfusion in Hepatectomized Rat Liver Model
M. Aburawi¹, S. Mert¹, E. Hafiz², P. Mahboub¹, H. Yeh¹, K. Uygun¹, J. Markmann¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology and Electron Microscopy, Theodor Bilharz Research Institute, Cairo, Egypt
*Purpose: Realizing the liver’s unique ability to regenerate, this ongoing study examines Normothermic Machine Perfusion (NMP) as a promising platform for evaluating & potentially simulating…
2019 American Transplant Congress
PD-1+CD3+CD4-CD8- (Double Negative T-cells) Are Early Responders during Kidney Ischemia Reperfusion Injury and Regulated by Non-Classical MHC Molecules
M. Sadasivam, S. Noel, S. Lee, J. Gong, A. Hamad, H. Rabb
Johns Hopkins University and School of Medicine, Baltimore, MD
*Purpose: Unconventional T-cells (e.g. Tregs and γδT-cells) are increasingly recognized for their roles in maintaining homeostasis and protecting non-lymphoid tissues against injury/stress. Double negative (DN)…
2019 American Transplant Congress
Histologic Ischemia Reperfusion Injury in Liver Transplantation: A Large Single Center Experience
F. M. Kaldas, T. Ito, S. Younan, J. Aziz, M. Lu, V. G. Agopian, J. DiNorcia III, H. Yersiz, D. G. Farmer, R. W. Busuttil
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Ischemia Reperfusion Injury (IRI) is known to adversely affect graft outcomes in Liver Transplantation (LT). Large series examining the significance of IRI found on…