ATC Abstracts

American Transplant Congress abstracts

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  • 2019 American Transplant Congress

    Perioperative Blood Transfusion Significantly Increases Inpatient Morbidity and Mortality in Renal Transplant Recipients: 15-year Experience

    K. Mahendraraj1, G. Medrano del Rosal1, M. Kruse1, R. Shah1, T. Katsichtis1, T. Brennan2, N. Nissen2, T. Todo2, K. Kosari2, A. Klein2, I. Kim2

    1Surgery, Lincoln Medical Center, New York, NY, 2Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: This study evaluates the immediate effects of perioperative blood transfusion (PBT) on inpatient morbidity and mortality among renal transplant (RT) recipients during their index…
  • 2019 American Transplant Congress

    Barriers to Pre-Transplant Immunization: A Qualitative Study of Pediatric Liver-Transplant Stakeholders

    A. G. Feldman1, R. Marsh2, A. Kempe3, M. Morris2

    1Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado, Aurora, CO, 2University of Colorado, Aurora, CO, 3Pediatrics, University of Colorado, Aurora, CO

    *Purpose: Less than 30% of pediatric liver transplant recipients are up-to-date on age-appropriate immunizations at the time of transplant despite being at high-risk for infections…
  • 2019 American Transplant Congress

    Ablation of Interferon Regulatory Factor 4 in T Cells Induces “Memory” of Transplant Tolerance That is Irreversible by Immune Checkpoint Blockade

    H. Zhang1, J. Wu2, D. Zou3, W. Chen3

    1The second Xiangya Hospital, Changsha, China, 2Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 3Immunobiology & Transplant Science Center, Houston Methodist Research Institute, Houston, TX

    *Purpose: Achieving alloantigen-specific transplant tolerance through ablation of interferon regulatory factor 4 in T cells*Methods: 1. Irf4fl/flCD4-Cre recipients were first transplanted with BALB/c hearts and…
  • 2019 American Transplant Congress

    Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice

    Y. Huang, H. Xu, Y. Wen, S. Ildstad

    University of Louisville, Louisville, KY

    *Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…
  • 2019 American Transplant Congress

    Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy

    M. Ma, P. Chhabra, K. Brayman

    Surgery, University of Virginia, Charlottesville, VA

    *Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
  • 2019 American Transplant Congress

    Population-Based Modeling of Prototypes and Determinants of Allograft Function Trajectories after Kidney Transplantation: Impact for Patient Monitoring and Risk Stratification

    M. Raynaud1, O. Aubert1, M. Naesens2, I. Juric3, N. Basic3, N. Kamar4, E. Huang5, S. Jordan5, B. Orandi6, D. Segev6, M. Stegall7, E. Morelon8, M. Giral9, E. Bailly10, E. Akalin11, G. Gupta12, M. Ladrière13, M. Buchler10, P. Reese14, C. Lefaucheur1, A. Loupy1

    1Paris, ., France, 2Leuven, ., Belgium, 3Zagreb, ., Croatia, 4Toulouse, ., France, 5Los Angeles, ., CA, 6Baltimore, ., MD, 7Rochester, ., MN, 8Lyon, ., France, 9Nantes, ., France, 10Tours, ., France, 11New York, ., NY, 12Richmond, ., VA, 13Nancy, ., France, 14Philadelphia, ., PA

    *Purpose: Although the current gold standard of kidney allograft patients monitoring relies on GFR assessment, little is known about long-term GFR trajectories prototypes and their…
  • 2019 American Transplant Congress

    Outcomes in Non-A1 and Non A1 B to B Deceased Donor Renal Transplantation Are Comparable to B Donor Renal Transplants

    A. Brar, L. Kwon, A. Gruessner, F. Tedla, R. Gruessner, N. Sumrani, D. John, J. Renz, M. O. Salifu

    SUNY Downstate Medical Center, Brooklyn, NY

    *Purpose: Blood type B patients wait longer to get deceased donor (DD) renal transplants compared to other blood types. On December 2014, the US national…
  • 2019 American Transplant Congress

    Robotic-Assisted versus Open- Kidney Transplantation in Non-Obese Recipients

    P. R. Modi, B. Pal, S. Singla, R. Chauhan, V. Kothari, A. Mishra, M. Modi, B. Butala, V. Kute, H. Patel, V. Trivedi

    Transplantation Surgery and Urology, Institute of Kidney Diseases and Research Centre, Ahmedabad, India

    *Purpose: Robotic Kidney Transplantation (RKT) is emerging modality of treatment for patient with end stage kidney diseases. It is accepted for obese recipients. However, there…
  • 2019 American Transplant Congress

    An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation

    E. Van Loon1, S. Gazut2, S. Yazdani1, E. Lerut1, H. de Loor1, M. Coemans1, L. Noël3, L. Thorrez1, L. Van Lommel1, F. Schuit1, D. Lambrechts1, T. Van Brussel1, B. Sprangers1, D. Kuypers1, M. Essig4, W. Gwinner5, D. Anglicheau6, P. Marquet7, M. Naesens1

    1Catholic University Leuven, Leuven, Belgium, 2CEA, Gif-sur-Yvette, France, 3Necker-Enfants Malades Institute, Paris, France, 4CHU Limoges, Limoges, France, 5Hannover Medical School, Hannover, Germany, 6Paris Descartes, Sorbonne Paris Cité University, Paris, France, 7RTRS Centaure, Necker Hospital, Paris, France

    *Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…
  • 2019 American Transplant Congress

    Novel Activation Responses by Endothelial Cells within the Pro-Tolerogenic Intragraft Microenvironment

    J. Wedel1, K. Liu1, P. T. Sage2, C. V. Carman3, P. Bobrowicz4, S. Kong5, B. McLaughlin4, D. M. Briscoe1

    1Transplant Research Program, Boston Children's Hospital, Boston, MA, 2Transplant Research Center, Brigham and Woman Hospital, Boston, MA, 3Harvard T.H. Chan School of Public Health, Boston, MA, 4Compass Therapeutics, Cambridge, MA, 5Computational Health Informatics Program, Boston Children's Hospital, Boston, MA

    *Purpose: Current paradigms indicate that endothelial cells (EC) within allografts participate in the initiation and progression of allograft rejection. However, little is known about their…
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