2019 American Transplant Congress
Perioperative Blood Transfusion Significantly Increases Inpatient Morbidity and Mortality in Renal Transplant Recipients: 15-year Experience
*Purpose: This study evaluates the immediate effects of perioperative blood transfusion (PBT) on inpatient morbidity and mortality among renal transplant (RT) recipients during their index…2019 American Transplant Congress
Barriers to Pre-Transplant Immunization: A Qualitative Study of Pediatric Liver-Transplant Stakeholders
*Purpose: Less than 30% of pediatric liver transplant recipients are up-to-date on age-appropriate immunizations at the time of transplant despite being at high-risk for infections…2019 American Transplant Congress
Ablation of Interferon Regulatory Factor 4 in T Cells Induces “Memory” of Transplant Tolerance That is Irreversible by Immune Checkpoint Blockade
*Purpose: Achieving alloantigen-specific transplant tolerance through ablation of interferon regulatory factor 4 in T cells*Methods: 1. Irf4fl/flCD4-Cre recipients were first transplanted with BALB/c hearts and…2019 American Transplant Congress
Prevention of Diabetes in the NOD Mice Reconstituted with Bone Marrow Cells from Allogeneic CD4 Knockout, CD8 Knockout or B-Cell Knockout B6 Mice
University of Louisville, Louisville, KY
*Purpose: Type 1 diabetes (T1D) is an autoimmune disorder characterized by destruction of the pancreatic beta cells by both humoral- and cell-mediated immune mechanisms. Transplantation…2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…2019 American Transplant Congress
Population-Based Modeling of Prototypes and Determinants of Allograft Function Trajectories after Kidney Transplantation: Impact for Patient Monitoring and Risk Stratification
*Purpose: Although the current gold standard of kidney allograft patients monitoring relies on GFR assessment, little is known about long-term GFR trajectories prototypes and their…2019 American Transplant Congress
Outcomes in Non-A1 and Non A1 B to B Deceased Donor Renal Transplantation Are Comparable to B Donor Renal Transplants
SUNY Downstate Medical Center, Brooklyn, NY
*Purpose: Blood type B patients wait longer to get deceased donor (DD) renal transplants compared to other blood types. On December 2014, the US national…2019 American Transplant Congress
Robotic-Assisted versus Open- Kidney Transplantation in Non-Obese Recipients
*Purpose: Robotic Kidney Transplantation (RKT) is emerging modality of treatment for patient with end stage kidney diseases. It is accepted for obese recipients. However, there…2019 American Transplant Congress
An 8-Gene Expression Assay in Peripheral Blood for Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation
*Purpose: Antibody-mediated rejection is a leading cause of graft failure after kidney transplantation. The diagnosis of antibody-mediated rejection is made by combining assessment of circulating…2019 American Transplant Congress
Novel Activation Responses by Endothelial Cells within the Pro-Tolerogenic Intragraft Microenvironment
*Purpose: Current paradigms indicate that endothelial cells (EC) within allografts participate in the initiation and progression of allograft rejection. However, little is known about their…
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